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Items: 1 to 20 of 170

1.

Dynamics of pre-replicative complex assembly.

Tsakraklides V, Bell SP.

J Biol Chem. 2010 Mar 26;285(13):9437-43. doi: 10.1074/jbc.M109.072504. Epub 2010 Jan 22.

2.

Sequential ATP hydrolysis by Cdc6 and ORC directs loading of the Mcm2-7 helicase.

Randell JC, Bowers JL, Rodríguez HK, Bell SP.

Mol Cell. 2006 Jan 6;21(1):29-39.

3.

An ORC/Cdc6/MCM2-7 complex is formed in a multistep reaction to serve as a platform for MCM double-hexamer assembly.

Fernández-Cid A, Riera A, Tognetti S, Herrera MC, Samel S, Evrin C, Winkler C, Gardenal E, Uhle S, Speck C.

Mol Cell. 2013 May 23;50(4):577-88. doi: 10.1016/j.molcel.2013.03.026. Epub 2013 Apr 18.

4.

In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization.

Evrin C, Fernández-Cid A, Zech J, Herrera MC, Riera A, Clarke P, Brill S, Lurz R, Speck C.

Nucleic Acids Res. 2013 Mar 1;41(5):3162-72. doi: 10.1093/nar/gkt043. Epub 2013 Feb 1.

5.

Orc6 is required for dynamic recruitment of Cdt1 during repeated Mcm2-7 loading.

Chen S, de Vries MA, Bell SP.

Genes Dev. 2007 Nov 15;21(22):2897-907.

6.

Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA.

Sun J, Evrin C, Samel SA, Fernández-Cid A, Riera A, Kawakami H, Stillman B, Speck C, Li H.

Nat Struct Mol Biol. 2013 Aug;20(8):944-51. doi: 10.1038/nsmb.2629. Epub 2013 Jul 14.

7.

The dynamics of eukaryotic replication initiation: origin specificity, licensing, and firing at the single-molecule level.

Duzdevich D, Warner MD, Ticau S, Ivica NA, Bell SP, Greene EC.

Mol Cell. 2015 May 7;58(3):483-94. doi: 10.1016/j.molcel.2015.03.017. Epub 2015 Apr 23.

8.

The ORC/Cdc6/MCM2-7 complex facilitates MCM2-7 dimerization during prereplicative complex formation.

Evrin C, Fernández-Cid A, Riera A, Zech J, Clarke P, Herrera MC, Tognetti S, Lurz R, Speck C.

Nucleic Acids Res. 2014 Feb;42(4):2257-69. doi: 10.1093/nar/gkt1148. Epub 2013 Nov 14.

9.

A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication.

Evrin C, Clarke P, Zech J, Lurz R, Sun J, Uhle S, Li H, Stillman B, Speck C.

Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20240-5. doi: 10.1073/pnas.0911500106. Epub 2009 Nov 12.

10.

CDK prevents Mcm2-7 helicase loading by inhibiting Cdt1 interaction with Orc6.

Chen S, Bell SP.

Genes Dev. 2011 Feb 15;25(4):363-72. doi: 10.1101/gad.2011511. Epub 2011 Feb 2.

11.
12.

ATP hydrolysis by ORC catalyzes reiterative Mcm2-7 assembly at a defined origin of replication.

Bowers JL, Randell JC, Chen S, Bell SP.

Mol Cell. 2004 Dec 22;16(6):967-78.

13.

Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1.

Yuan Z, Riera A, Bai L, Sun J, Nandi S, Spanos C, Chen ZA, Barbon M, Rappsilber J, Stillman B, Speck C, Li H.

Nat Struct Mol Biol. 2017 Mar;24(3):316-324. doi: 10.1038/nsmb.3372. Epub 2017 Feb 13.

14.

Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing.

Remus D, Beuron F, Tolun G, Griffith JD, Morris EP, Diffley JF.

Cell. 2009 Nov 13;139(4):719-30. doi: 10.1016/j.cell.2009.10.015. Epub 2009 Nov 5.

15.

Multiple Cdt1 molecules act at each origin to load replication-competent Mcm2-7 helicases.

Takara TJ, Bell SP.

EMBO J. 2011 Nov 1;30(24):4885-96. doi: 10.1038/emboj.2011.394.

16.

Pre-replicative complex assembly with purified proteins.

Mehanna A, Diffley JF.

Methods. 2012 Jun;57(2):222-6. doi: 10.1016/j.ymeth.2012.06.008. Epub 2012 Jun 23.

PMID:
22732456
17.

Reconstitution of Saccharomyces cerevisiae prereplicative complex assembly in vitro.

Kawasaki Y, Kim HD, Kojima A, Seki T, Sugino A.

Genes Cells. 2006 Jul;11(7):745-56.

18.

Origin licensing requires ATP binding and hydrolysis by the MCM replicative helicase.

Coster G, Frigola J, Beuron F, Morris EP, Diffley JF.

Mol Cell. 2014 Sep 4;55(5):666-77. doi: 10.1016/j.molcel.2014.06.034. Epub 2014 Jul 31.

19.

ATPase-dependent quality control of DNA replication origin licensing.

Frigola J, Remus D, Mehanna A, Diffley JF.

Nature. 2013 Mar 21;495(7441):339-43. doi: 10.1038/nature11920. Epub 2013 Mar 10.

20.

Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication.

Chang F, Riera A, Evrin C, Sun J, Li H, Speck C, Weinreich M.

Elife. 2015 Aug 25;4. doi: 10.7554/eLife.05795.

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