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Items: 1 to 20 of 96

1.

Direct detection of the hydrolysis of nerve agent model compounds using a fluorescent probe.

Zheng X, Okolotowicz K, Wang B, Macdonald M, Cashman JR, Zhang J.

Chem Biol Interact. 2010 Sep 6;187(1-3):330-4. doi: 10.1016/j.cbi.2010.01.027.

2.

Identification of human butyrylcholinesterase organophosphate-resistant variants through a novel mammalian enzyme functional screen.

Zhang J, Chen S, Ralph EC, Dwyer M, Cashman JR.

J Pharmacol Exp Ther. 2012 Dec;343(3):673-82. doi: 10.1124/jpet.112.198499.

3.

In search of a catalytic bioscavenger for the prophylaxis of nerve agent toxicity.

diTargiani RC, Chandrasekaran L, Belinskaya T, Saxena A.

Chem Biol Interact. 2010 Sep 6;187(1-3):349-54. doi: 10.1016/j.cbi.2010.02.021.

PMID:
20176006
4.

Organophosphate hydrolases as catalytic bioscavengers of organophosphorus nerve agents.

Trovaslet-Leroy M, Musilova L, Renault F, Brazzolotto X, Misik J, Novotny L, Froment MT, Gillon E, Loiodice M, Verdier L, Masson P, Rochu D, Jun D, Nachon F.

Toxicol Lett. 2011 Sep 25;206(1):14-23. doi: 10.1016/j.toxlet.2011.05.1041.

PMID:
21683774
5.

Bioscavengers for the protection of humans against organophosphate toxicity.

Doctor BP, Saxena A.

Chem Biol Interact. 2005 Dec 15;157-158:167-71.

PMID:
16293236
6.

Nerve agent analogues that produce authentic soman, sarin, tabun, and cyclohexyl methylphosphonate-modified human butyrylcholinesterase.

Gilley C, MacDonald M, Nachon F, Schopfer LM, Zhang J, Cashman JR, Lockridge O.

Chem Res Toxicol. 2009 Oct;22(10):1680-8. doi: 10.1021/tx900090m.

7.

Suitability of human butyrylcholinesterase as therapeutic marker and pseudo catalytic scavenger in organophosphate poisoning: a kinetic analysis.

Aurbek N, Thiermann H, Eyer F, Eyer P, Worek F.

Toxicology. 2009 May 17;259(3):133-9. doi: 10.1016/j.tox.2009.02.014.

PMID:
19428953
8.

Nerve agent hydrolysis activity designed into a human drug metabolism enzyme.

Hemmert AC, Otto TC, Chica RA, Wierdl M, Edwards JS, Lewis SM, Edwards CC, Tsurkan L, Cadieux CL, Kasten SA, Cashman JR, Mayo SL, Potter PM, Cerasoli DM, Redinbo MR.

PLoS One. 2011 Mar 18;6(3):e17441. doi: 10.1371/journal.pone.0017441. Erratum in: PLoS One. 2012;7(1). doi:10.1371/annotation/c5953f27-95f8-4a1b-a46c-639d90e182ac. Lewis, Steven L [corrected to Lewis, Steven M].

9.

In vivo reactivation by oximes of inhibited blood, brain and peripheral tissue cholinesterase activity following exposure to nerve agents in guinea pigs.

Shih TM, Skovira JW, O'Donnell JC, McDonough JH.

Chem Biol Interact. 2010 Sep 6;187(1-3):207-14. doi: 10.1016/j.cbi.2010.03.006.

PMID:
20223229
10.

Crystal structures of human group-VIIA phospholipase A2 inhibited by organophosphorus nerve agents exhibit non-aged complexes.

Samanta U, Kirby SD, Srinivasan P, Cerasoli DM, Bahnson BJ.

Biochem Pharmacol. 2009 Aug 15;78(4):420-9. doi: 10.1016/j.bcp.2009.04.018.

11.

In vitro efficacy of paraoxonase 1 from multiple sources against various organophosphates.

Valiyaveettil M, Alamneh Y, Biggemann L, Soojhawon I, Farag HA, Agrawal P, Doctor BP, Nambiar MP.

Toxicol In Vitro. 2011 Jun;25(4):905-13. doi: 10.1016/j.tiv.2011.02.012.

PMID:
21382471
12.

Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin.

Hemmert AC, Otto TC, Wierdl M, Edwards CC, Fleming CD, MacDonald M, Cashman JR, Potter PM, Cerasoli DM, Redinbo MR.

Mol Pharmacol. 2010 Apr;77(4):508-16. doi: 10.1124/mol.109.062356.

13.

Catalytic detoxification of nerve agent and pesticide organophosphates by butyrylcholinesterase assisted with non-pyridinium oximes.

Radić Z, Dale T, Kovarik Z, Berend S, Garcia E, Zhang L, Amitai G, Green C, Radić B, Duggan BM, Ajami D, Rebek J, Taylor P.

Biochem J. 2013 Feb 15;450(1):231-42. doi: 10.1042/BJ20121612.

14.

Progress in the development of enzyme-based nerve agent bioscavengers.

Nachon F, Brazzolotto X, Trovaslet M, Masson P.

Chem Biol Interact. 2013 Dec 5;206(3):536-44. doi: 10.1016/j.cbi.2013.06.012. Review.

PMID:
23811386
15.

Identification and characterization of novel catalytic bioscavengers of organophosphorus nerve agents.

Otto TC, Scott JR, Kauffman MA, Hodgins SM, Ditargiani RC, Hughes JH, Sarricks EP, Saturday GA, Hamilton TA, Cerasoli DM.

Chem Biol Interact. 2013 Mar 25;203(1):186-90. doi: 10.1016/j.cbi.2012.09.009.

PMID:
23041042
16.

Nonquaternary reactivators for organophosphate-inhibited cholinesterases.

Kalisiak J, Ralph EC, Cashman JR.

J Med Chem. 2012 Jan 12;55(1):465-74. doi: 10.1021/jm201364d.

PMID:
22206546
17.

Evaluation of oxime efficacy in nerve agent poisoning: development of a kinetic-based dynamic model.

Worek F, Szinicz L, Eyer P, Thiermann H.

Toxicol Appl Pharmacol. 2005 Dec 15;209(3):193-202.

PMID:
15904945
18.

Probing the role of amino acids in oxime-mediated reactivation of nerve agent-inhibited human acetylcholinesterase.

Chambers C, Luo C, Tong M, Yang Y, Saxena A.

Toxicol In Vitro. 2015 Mar;29(2):408-14. doi: 10.1016/j.tiv.2014.11.001.

PMID:
25451328
19.

A collaborative endeavor to design cholinesterase-based catalytic scavengers against toxic organophosphorus esters.

Masson P, Nachon F, Broomfield CA, Lenz DE, Verdier L, Schopfer LM, Lockridge O.

Chem Biol Interact. 2008 Sep 25;175(1-3):273-80. doi: 10.1016/j.cbi.2008.04.005.

PMID:
18508040
20.

In vitro characterization of organophosphorus compound hydrolysis by native and recombinant human prolidase.

Chandrasekaran L, Belinskaya T, Saxena A.

Toxicol In Vitro. 2013 Feb;27(1):499-506. doi: 10.1016/j.tiv.2012.05.012.

PMID:
22677456
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