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Soluble TLT-1 modulates platelet-endothelial cell interactions and actin polymerization.

Morales J, Villa K, Gattis J, Castro W, Colon K, Lubkowski J, Sanabria P, Hunter R, Washington AV.

Blood Coagul Fibrinolysis. 2010 Apr;21(3):229-36. doi: 10.1097/MBC.0b013e3283358116.


TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans.

Washington AV, Gibot S, Acevedo I, Gattis J, Quigley L, Feltz R, De La Mota A, Schubert RL, Gomez-Rodriguez J, Cheng J, Dutra A, Pak E, Chertov O, Rivera L, Morales J, Lubkowski J, Hunter R, Schwartzberg PL, McVicar DW.

J Clin Invest. 2009 Jun;119(6):1489-501. doi: 10.1172/JCI36175. Epub 2009 May 11.


A TREM family member, TLT-1, is found exclusively in the alpha-granules of megakaryocytes and platelets.

Washington AV, Schubert RL, Quigley L, Disipio T, Feltz R, Cho EH, McVicar DW.

Blood. 2004 Aug 15;104(4):1042-7. Epub 2004 Apr 20.


Clinical studies support a role for trem-like transcript-1 during the progression of sepsis.

Esponda O, Morales J, Aguilar A, Gomez M, Washington AV.

Bol Asoc Med P R. 2010 Jul-Sep;102(3):59-61. Review.


The structure of the extracellular domain of triggering receptor expressed on myeloid cells like transcript-1 and evidence for a naturally occurring soluble fragment.

Gattis JL, Washington AV, Chisholm MM, Quigley L, Szyk A, McVicar DW, Lubkowski J.

J Biol Chem. 2006 May 12;281(19):13396-403. Epub 2006 Feb 27.


Inhibition of thrombin-induced platelet aggregation using human single-chain Fv antibodies specific for TREM-like transcript-1.

Giomarelli B, Washington VA, Chisholm MM, Quigley L, McMahon JB, Mori T, McVicar DW.

Thromb Haemost. 2007 Jun;97(6):955-63.


Soluble TREM-like transcript-1 regulates leukocyte activation and controls microbial sepsis.

Derive M, Bouazza Y, Sennoun N, Marchionni S, Quigley L, Washington V, Massin F, Max JP, Ford J, Alauzet C, Levy B, McVicar DW, Gibot S.

J Immunol. 2012 Jun 1;188(11):5585-92. doi: 10.4049/jimmunol.1102674. Epub 2012 May 2.


Preparation and characterization of monoclonal antibody against protein TREM-like transcript-1 (TLT-1).

Lu YT, Yen CY, Ho HC, Chen CJ, Wu MF, Hsieh SL.

Hybridoma (Larchmt). 2006 Feb;25(1):20-6.


Phenotypic heterogeneity in the Gray platelet syndrome extends to the expression of TREM family member, TLT-1.

Nurden AT, Nurden P, Bermejo E, Combrié R, McVicar DW, Washington AV.

Thromb Haemost. 2008 Jul;100(1):45-51. doi: 10.1160/TH08-02-0067.


Initial characterization of TREM-like transcript (TLT)-1: a putative inhibitory receptor within the TREM cluster.

Washington AV, Quigley L, McVicar DW.

Blood. 2002 Nov 15;100(10):3822-4. Epub 2002 Jul 12.


Interaction with damaged vessel wall in vivo in humans induces platelets to express CD40L resulting in endothelial activation with no effect of aspirin intake.

Giannini S, Falcinelli E, Bury L, Guglielmini G, Rossi R, Momi S, Gresele P.

Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2072-9. doi: 10.1152/ajpheart.00467.2010. Epub 2011 Mar 4.


Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses.

Hashiguchi M, Kobori H, Ritprajak P, Kamimura Y, Kozono H, Azuma M.

Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10495-500. doi: 10.1073/pnas.0802423105. Epub 2008 Jul 23. Erratum in: Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14744.


Enhancement of effector CD8+ T-cell function by tumour-associated B7-H3 and modulation of its counter-receptor triggering receptor expressed on myeloid cell-like transcript 2 at tumour sites.

Kobori H, Hashiguchi M, Piao J, Kato M, Ritprajak P, Azuma M.

Immunology. 2010 Jul;130(3):363-73. doi: 10.1111/j.1365-2567.2009.03236.x. Epub 2010 Feb 5.


TREM and TREM-like receptors in inflammation and disease.

Ford JW, McVicar DW.

Curr Opin Immunol. 2009 Feb;21(1):38-46. doi: 10.1016/j.coi.2009.01.009. Epub 2009 Feb 21. Review.


Integrin alpha 2-deficient mice develop normally, are fertile, but display partially defective platelet interaction with collagen.

Holtkötter O, Nieswandt B, Smyth N, Müller W, Hafner M, Schulte V, Krieg T, Eckes B.

J Biol Chem. 2002 Mar 29;277(13):10789-94. Epub 2002 Jan 11.


Platelet CD40 Exacerbates Atherosclerosis by Transcellular Activation of Endothelial Cells and Leukocytes.

Gerdes N, Seijkens T, Lievens D, Kuijpers MJ, Winkels H, Projahn D, Hartwig H, Beckers L, Megens RT, Boon L, Noelle RJ, Soehnlein O, Heemskerk JW, Weber C, Lutgens E.

Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):482-90. doi: 10.1161/ATVBAHA.115.307074. Epub 2016 Jan 28.


Signaling pathways of the F11 receptor (F11R; a.k.a. JAM-1, JAM-A) in human platelets: F11R dimerization, phosphorylation and complex formation with the integrin GPIIIa.

Sobocka MB, Sobocki T, Babinska A, Hartwig JH, Li M, Ehrlich YH, Kornecki E.

J Recept Signal Transduct Res. 2004 Feb;24(1-2):85-105.


TREM-1 ligand expression on platelets enhances neutrophil activation.

Haselmayer P, Grosse-Hovest L, von Landenberg P, Schild H, Radsak MP.

Blood. 2007 Aug 1;110(3):1029-35. Epub 2007 Apr 23.

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