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Items: 1 to 20 of 58

1.

Synthesis and structure-activity relationship of substitutions at the C-1 position of Delta9-tetrahydrocannabinol.

Burdick D, DeOrazio R, Guzzo P, Habershaw A, Helle M, Paul B, Wolf M.

Bioorg Med Chem Lett. 2010 Feb 15;20(4):1424-6. doi: 10.1016/j.bmcl.2009.12.092. Epub 2010 Jan 4.

PMID:
20079638
2.

3-(1',1'-Dimethylbutyl)-1-deoxy-delta8-THC and related compounds: synthesis of selective ligands for the CB2 receptor.

Huffman JW, Liddle J, Yu S, Aung MM, Abood ME, Wiley JL, Martin BR.

Bioorg Med Chem. 1999 Dec;7(12):2905-14.

PMID:
10658595
3.

(-)-Delta9-tetrahydrocannabinol antagonizes the peripheral cannabinoid receptor-mediated inhibition of adenylyl cyclase.

Bayewitch M, Rhee MH, Avidor-Reiss T, Breuer A, Mechoulam R, Vogel Z.

J Biol Chem. 1996 Apr 26;271(17):9902-5.

4.

Pharmacophoric requirements for cannabinoid side chains: multiple bond and C1'-substituted delta 8-tetrahydrocannabinols.

Papahatjis DP, Kourouli T, Abadji V, Goutopoulos A, Makriyannis A.

J Med Chem. 1998 Mar 26;41(7):1195-200.

PMID:
9544219
5.

Potent cyano and carboxamido side-chain analogues of 1', 1'-dimethyl-delta8-tetrahydrocannabinol.

Singer M, Ryan WJ, Saha B, Martin BR, Razdan RK.

J Med Chem. 1998 Oct 22;41(22):4400-7.

PMID:
9784115
6.

Structural determinants of the partial agonist-inverse agonist properties of 6'-azidohex-2'-yne-delta8-tetrahydrocannabinol at cannabinoid receptors.

Ross RA, Gibson TM, Stevenson LA, Saha B, Crocker P, Razdan RK, Pertwee RG.

Br J Pharmacol. 1999 Oct;128(3):735-43.

7.

Effects of chronic exposure to delta9-tetrahydrocannabinol on cannabinoid receptor binding and mRNA levels in several rat brain regions.

Romero J, Garcia-Palomero E, Castro JG, Garcia-Gil L, Ramos JA, Fernandez-Ruiz JJ.

Brain Res Mol Brain Res. 1997 Jun;46(1-2):100-8.

PMID:
9191083
8.

Novel conformationally restricted tetracyclic analogs of delta8-tetrahydrocannabinol.

Khanolkar AD, Lu D, Fan P, Tian X, Makriyannis A.

Bioorg Med Chem Lett. 1999 Aug 2;9(15):2119-24.

PMID:
10465529
9.

Exploring the substituent effects on a novel series of C1'-dimethyl-aryl Delta8-tetrahydrocannabinol analogs.

Krishnamurthy M, Gurley S, Moore BM 2nd.

Bioorg Med Chem. 2008 Jul 1;16(13):6489-500. doi: 10.1016/j.bmc.2008.05.034. Epub 2008 May 20.

PMID:
18524604
10.

1-Methoxy-, 1-deoxy-11-hydroxy- and 11-hydroxy-1-methoxy-Delta(8)-tetrahydrocannabinols: new selective ligands for the CB2 receptor.

Huffman JW, Bushell SM, Miller JR, Wiley JL, Martin BR.

Bioorg Med Chem. 2002 Dec;10(12):4119-29.

PMID:
12413866
11.

Perinatal delta9-tetrahydrocannabinol exposure augmented the magnitude of motor inhibition caused by GABA(B), but not GABA(A), receptor agonists in adult rats.

Garcia-Gil L, de Miguel R, Romero J, Perez A, Ramos JA, Fernández-Ruiz JJ.

Neurotoxicol Teratol. 1999 May-Jun;21(3):277-83.

PMID:
10386831
12.

Novel 1',1'-chain substituted Delta(8)-tetrahydrocannabinols.

Papahatjis DP, Nikas SP, Andreou T, Makriyannis A.

Bioorg Med Chem Lett. 2002 Dec 16;12(24):3583-6.

PMID:
12443781
13.

Synthesis and pharmacology of the isomeric methylheptyl-delta8-tetrahydrocannabinols.

Huffman JW, Liddle J, Duncan SG Jr, Yu S, Martin BR, Wiley JL.

Bioorg Med Chem. 1998 Dec;6(12):2383-96.

PMID:
9925296
14.

QSAR analysis of Delta(8)-THC analogues: relationship of side-chain conformation to cannabinoid receptor affinity and pharmacological potency.

Keimowitz AR, Martin BR, Razdan RK, Crocker PJ, Mascarella SW, Thomas BF.

J Med Chem. 2000 Jan 13;43(1):59-70.

PMID:
10633038
16.

On the pharmacological properties of Delta9-tetrahydrocannabinol (THC).

Costa B.

Chem Biodivers. 2007 Aug;4(8):1664-77. Review.

PMID:
17712813
17.

Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'.

Papahatjis DP, Nikas SP, Kourouli T, Chari R, Xu W, Pertwee RG, Makriyannis A.

J Med Chem. 2003 Jul 17;46(15):3221-9.

PMID:
12852753
18.

Delta9-tetrahydrocannabinol immunochemical studies: haptens, monoclonal antibodies, and a convenient synthesis of radiolabeled delta9-tetrahydrocannabinol.

Qi L, Yamamoto N, Meijler MM, Altobell LJ 3rd, Koob GF, Wirsching P, Janda KD.

J Med Chem. 2005 Nov 17;48(23):7389-99.

PMID:
16279798
19.

Evaluation of agonist-antagonist properties of nitrogen mustard and cyano derivatives of delta 8-tetrahydrocannabinol.

Wiley JL, Compton DR, Gordon PM, Siegel C, Singer M, Dutta A, Lichtman AH, Balster RL, Razdan RK, Martin BR.

Neuropharmacology. 1996;35(12):1793-804.

PMID:
9076759
20.

Effects of long-term exposure to delta9-THC on expression of cannabinoid receptor (CB1) mRNA in different rat brain regions.

Zhuang S, Kittler J, Grigorenko EV, Kirby MT, Sim LJ, Hampson RE, Childers SR, Deadwyler SA.

Brain Res Mol Brain Res. 1998 Nov 20;62(2):141-9.

PMID:
9813289

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