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Items: 1 to 20 of 83

1.

Irs1 serine 307 promotes insulin sensitivity in mice.

Copps KD, Hancer NJ, Opare-Ado L, Qiu W, Walsh C, White MF.

Cell Metab. 2010 Jan;11(1):84-92. doi: 10.1016/j.cmet.2009.11.003.

2.

The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis.

Guo S, Copps KD, Dong X, Park S, Cheng Z, Pocai A, Rossetti L, Sajan M, Farese RV, White MF.

Mol Cell Biol. 2009 Sep;29(18):5070-83. doi: 10.1128/MCB.00138-09. Epub 2009 Jul 13.

3.

IRS1Ser³⁰⁷ phosphorylation does not mediate mTORC1-induced insulin resistance.

Herrema H, Lee J, Zhou Y, Copps KD, White MF, Ozcan U.

Biochem Biophys Res Commun. 2014 Jan 10;443(2):689-93. doi: 10.1016/j.bbrc.2013.12.023. Epub 2013 Dec 11.

4.

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2.

Copps KD, White MF.

Diabetologia. 2012 Oct;55(10):2565-2582. doi: 10.1007/s00125-012-2644-8. Epub 2012 Aug 8. Review.

5.

Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle.

Morino K, Neschen S, Bilz S, Sono S, Tsirigotis D, Reznick RM, Moore I, Nagai Y, Samuel V, Sebastian D, White M, Philbrick W, Shulman GI.

Diabetes. 2008 Oct;57(10):2644-51. doi: 10.2337/db06-0454. Epub 2008 Jul 15.

7.

Genetic analysis of type-1 insulin-like growth factor receptor signaling through insulin receptor substrate-1 and -2 in pancreatic beta cells.

Xuan S, Szabolcs M, Cinti F, Perincheri S, Accili D, Efstratiadis A.

J Biol Chem. 2010 Dec 24;285(52):41044-50. doi: 10.1074/jbc.M110.144790. Epub 2010 Oct 14.

8.

Effect of dehydroepiandrosterone (DHEA) on Akt and protein kinase C zeta (PKCζ) phosphorylation in different tissues of C57BL6, insulin receptor substrate (IRS)1(-/-), and IRS2(-/-) male mice fed a high-fat diet.

Aoki K, Tajima K, Taguri M, Terauchi Y.

J Steroid Biochem Mol Biol. 2016 May;159:110-20. doi: 10.1016/j.jsbmb.2016.03.011. Epub 2016 Mar 11.

PMID:
26976654
9.

Carrageenan Inhibits Insulin Signaling through GRB10-mediated Decrease in Tyr(P)-IRS1 and through Inflammation-induced Increase in Ser(P)307-IRS1.

Bhattacharyya S, Feferman L, Tobacman JK.

J Biol Chem. 2015 Apr 24;290(17):10764-74. doi: 10.1074/jbc.M114.630053. Epub 2015 Mar 17.

10.

Divergent Roles of IRS (Insulin Receptor Substrate) 1 and 2 in Liver and Skeletal Muscle.

Eckstein SS, Weigert C, Lehmann R.

Curr Med Chem. 2017;24(17):1827-1852. doi: 10.2174/0929867324666170426142826. Review.

PMID:
28462703
11.

Myocardial loss of IRS1 and IRS2 causes heart failure and is controlled by p38α MAPK during insulin resistance.

Qi Y, Xu Z, Zhu Q, Thomas C, Kumar R, Feng H, Dostal DE, White MF, Baker KM, Guo S.

Diabetes. 2013 Nov;62(11):3887-900. doi: 10.2337/db13-0095.

12.

Selective Insulin Resistance in the Kidney.

Horita S, Nakamura M, Suzuki M, Satoh N, Suzuki A, Seki G.

Biomed Res Int. 2016;2016:5825170. doi: 10.1155/2016/5825170. Epub 2016 May 9. Review.

13.

Leptin down-regulates insulin action through phosphorylation of serine-318 in insulin receptor substrate 1.

Hennige AM, Stefan N, Kapp K, Lehmann R, Weigert C, Beck A, Moeschel K, Mushack J, Schleicher E, Häring HU.

FASEB J. 2006 Jun;20(8):1206-8. Epub 2006 Apr 12.

PMID:
16611834
14.

APPL1 potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the insulin receptor.

Ryu J, Galan AK, Xin X, Dong F, Abdul-Ghani MA, Zhou L, Wang C, Li C, Holmes BM, Sloane LB, Austad SN, Guo S, Musi N, DeFronzo RA, Deng C, White MF, Liu F, Dong LQ.

Cell Rep. 2014 May 22;7(4):1227-38. doi: 10.1016/j.celrep.2014.04.006. Epub 2014 May 10.

15.

Positive and negative regulation of insulin signaling through IRS-1 phosphorylation.

Gual P, Le Marchand-Brustel Y, Tanti JF.

Biochimie. 2005 Jan;87(1):99-109. Review.

PMID:
15733744
16.

Application of network construction to estimate functional changes to insulin receptor substrates 1 and 2 in Huh7 cells following infection with the hepatitis C virus.

Liu J, Wang L, Wang W, Li Y, Jia X, Zhai S, Shi J, Dang S.

Mol Med Rep. 2016 Sep;14(3):2379-88. doi: 10.3892/mmr.2016.5527. Epub 2016 Jul 18.

17.

High uric acid directly inhibits insulin signalling and induces insulin resistance.

Zhu Y, Hu Y, Huang T, Zhang Y, Li Z, Luo C, Luo Y, Yuan H, Hisatome I, Yamamoto T, Cheng J.

Biochem Biophys Res Commun. 2014 May 16;447(4):707-14. doi: 10.1016/j.bbrc.2014.04.080. Epub 2014 Apr 21.

PMID:
24769205
18.

High-fat diet induces hepatic insulin resistance and impairment of synaptic plasticity.

Liu Z, Patil IY, Jiang T, Sancheti H, Walsh JP, Stiles BL, Yin F, Cadenas E.

PLoS One. 2015 May 29;10(5):e0128274. doi: 10.1371/journal.pone.0128274. eCollection 2015.

19.

Phosphorylation of Irs1 at SER-522 inhibits insulin signaling.

Giraud J, Haas M, Feener EP, Copps KD, Dong X, Dunn SL, White MF.

Mol Endocrinol. 2007 Sep;21(9):2294-302. Epub 2007 Jun 19.

PMID:
17579213
20.

IRS1 and IRS2: molecular characterization, tissue expression and transcriptional regulation by insulin in yellow catfish Pelteobagrus fulvidraco.

Zhuo MQ, Pan YX, Wu K, Xu YH, Zhang LH, Luo Z.

Fish Physiol Biochem. 2017 Apr;43(2):619-630. doi: 10.1007/s10695-016-0316-1. Epub 2016 Nov 18.

PMID:
27864748

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