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20056897,19409914,19647045,17928570,14962493,15364008,16336445,15317873,20492513,15821150,19628226,17936791,19174742,16617007,17673570,24337644,10534341,11093736,18061617,15641079,22219595,17541271,17582939,20546456,14657518,16782535,18394717,11742805,15877607,23211302,19361629,17418102,17292408,19429239,12604364,15289320,17484875,16208315,24571868,9603137,17130903,15720836,23116642,16929615,22219346,21374648,12598422,15199053,16434095,23988899,19217652,15819389,20146376,15988322,21749370,11954834,17053157,14662889,16552365,8398809,20029957,22560326,9878315,19047958,34831270,17102917,10781090,30196285,28348482,22561694,20594235,16804311,10692175,20303348,22151131,24356883,30925118,16830161,23035893,12145554,20170644,22562605,11897625,16083749,11890746,10837804,22371273,22027701,18045488,17151194,23740441,20451280,16829063,18845626,31887435,20594263,17086424,11925621,26039974,24631483,12353147,23934460,23376509,11961117,33220278,11266267,12740345,30458228,17523148,18718914,22425809,10827178,31561855,12759491,27664884,20174873,12379230,15723383,26269671,19159908,29161793,16034372,14695456,20719087,36150464,25131602,20970133,23397546,25126202,11282151,10905587,19283445,22706081,17183189,17436097,25008070,28748913,15126079,2101066,22504010,17676395,25978623,26383596,29360226,17927075,21419148,11231453,14642794,22309084,16479127,22003398,12508378,14715242,12969773,22193869,9466559,12850241,20803708,27501764,17885643,21596993,17075977,26161237,16791114,21189448,26598002,17161492,23089572,26400305,30610157,12071586,23376361,24096036,8871245,17845535,12883479,23295057,21083791,10509463,29518527,24140572,21382910,22820573,20676498,1342211,21737367,8336212,21086649,27880979,23184571,15519536,10847479,19926099,12895266,20883476,22564409,22027577,2687528,20858375,21778551,8135167,7790710,29852187,26418133,20713215,31059036,23295407,19538219,32761362,10757380,19639656,20128962,18516441,27524109,21436087,25356044,24502885,22381751,21527001,30193084,27693222,19489131,16162165,26012885,16639064,9405964,33710364,7544015,25967882,18950499,15612612,12477081,22246330,18648102,19912696,29748815,36963521,15377894,20428671,27955743,17900243,31590005,25973050,22381760,25469547,27833383,31071278,21377103,30055171,16317686,20877949,35068860,14527823,20107546,29728708,14559434,4556874,23590953,36138544,11131908,9565257,28673477,26256408,31894682,19941949,19176968,24148277,29201188,28460228,22030818,12081063,17256724,7579962,25774749,2629953,12853402,25438858,23311391,6745853,27556445,34355097,17182349,28044452,8603932,9249609,16981272,25095681,23240054,31173796,30205645,18595140,2101073,33029872,9886235,8773918,12845989,16534689,10793074,9878313,1419781,10807869,29384993,20944061,15204955,3231207,12604847,11575437,26365748,23103539,18680230,23703816,29516300,8931117,29263339,25450713,23284631,26281340,11093947,34114694,19731033,22985504,25371872,23243146,15115957,22117825,9114798,31772637,34735658,3228650,36590477,21521079,20567234,32052257,8997241,32736295,20212458,23604400,32822714,9523896,3482260,34567144,32341967,18516448,1823230,17435078,30574756,17007046,35943675,1972395,12048355,3751957,35955707,32928706,19785965,8682146,31420296,9536958,20847566,27212785,20929274,3553743,25022338,26989383,1784044,3192924,4079898,27989704,20084567,22511970,14694363,36463144,30280292,19115478,31312992,35289256,25896221,11820458,3579589,710856,22594838,10395046,27025036,23027202,21718959,2314093,31329536,4038322,28663674,15905118,27742301,27347059,33714428,23883516,10483747,2586421,16241007,18398495,27226149,20110735,26185375,14629625,35782765,26949501,22563168,21350812,9711467,8091182,35887010,7483709,8477976,34980718,19153193,21719332,3821086,19060984,22095461,21384092,27445694,12957136,2823730,1577227,32128089,16968543,33775645,21161002,29078089,11911350,7035283,8834367,7194515,10483748,24971217,14697999,3966534,12920245,25958307,7293977,23840968,23273144,33149861,18516451,24919042,19405400,34482313,7198165,33792809,27049497,8368445,1286576,19308270,13751331,13427581,34630953,3418077,7572773,27247902,24410545,2573777,2605482,2376124,25435143,5100882,13977126,13670595,14469674,26278563[uid]

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15-deoxy-delta 12,14-prostaglandin J2 prevents inflammatory response and endothelial cell damage in rats with acute obstructive cholangitis.

Watanabe K, Yokoyama Y, Kokuryo T, Kawai K, Kitagawa T, Seki T, Nakagawa A, Nagino M. Watanabe K, et al. Am J Physiol Gastrointest Liver Physiol. 2010 Mar;298(3):G410-8. doi: 10.1152/ajpgi.00233.2009. Epub 2010 Jan 7. Am J Physiol Gastrointest Liver Physiol. 2010. PMID: 20056897 Free article.

The 15-deoxy-Delta12,14-prostaglandin J2 inhibits LPS-stimulated AKT and NF-kappaB activation and suppresses interleukin-6 in osteoblast-like cells MC3T3E-1.

Jung WK, Park IS, Park SJ, Yea SS, Choi YH, Oh S, Park SG, Choi IW. Jung WK, et al. Life Sci. 2009 Jul 3;85(1-2):46-53. doi: 10.1016/j.lfs.2009.04.010. Epub 2009 May 3. Life Sci. 2009. PMID: 19409914

Activation of peripheral kappa/delta opioid receptors mediates 15-deoxy-(Delta12,14)-prostaglandin J2 induced-antinociception in rat temporomandibular joint.

Pena-dos-Santos DR, Severino FP, Pereira SA, Rodrigues DB, Cunha FQ, Vieira SM, Napimoga MH, Clemente-Napimoga JT. Pena-dos-Santos DR, et al. Neuroscience. 2009 Nov 10;163(4):1211-9. doi: 10.1016/j.neuroscience.2009.07.052. Epub 2009 Jul 30. Neuroscience. 2009. PMID: 19647045

15d-prostaglandin J2 inhibits inflammatory hypernociception: involvement of peripheral opioid receptor.

Napimoga MH, Souza GR, Cunha TM, Ferrari LF, Clemente-Napimoga JT, Parada CA, Verri WA Jr, Cunha FQ, Ferreira SH. Napimoga MH, et al. J Pharmacol Exp Ther. 2008 Jan;324(1):313-21. doi: 10.1124/jpet.107.126045. Epub 2007 Oct 10. J Pharmacol Exp Ther. 2008. PMID: 17928570

The cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J2 ameliorates ischemic acute renal failure.

Chatterjee PK, Patel NS, Cuzzocrea S, Brown PA, Stewart KN, Mota-Filipe H, Britti D, Eberhardt W, Pfeilschifter J, Thiemermann C. Chatterjee PK, et al. Cardiovasc Res. 2004 Feb 15;61(3):630-43. doi: 10.1016/j.cardiores.2003.10.024. Cardiovasc Res. 2004. PMID: 14962493

15d-prostaglandin J2 reduces multiple organ failure caused by wall-fragment of Gram-positive and Gram-negative bacteria.

Dugo L, Collin M, Cuzzocrea S, Thiemermann C. Dugo L, et al. Eur J Pharmacol. 2004 Sep 13;498(1-3):295-301. doi: 10.1016/j.ejphar.2004.07.074. Eur J Pharmacol. 2004. PMID: 15364008

Obstructive jaundice increases sensitivity to lipopolysaccharide via TLR4 upregulation: possible involvement in gut-derived hepatocyte growth factor-protection of hepatocytes.

Miyaso H, Morimoto Y, Ozaki M, Haga S, Shinoura S, Choda Y, Iwagaki H, Tanaka N. Miyaso H, et al. J Gastroenterol Hepatol. 2005 Dec;20(12):1859-66. doi: 10.1111/j.1440-1746.2005.03953.x. J Gastroenterol Hepatol. 2005. PMID: 16336445

Protein thiol modification by 15-deoxy-Delta12,14-prostaglandin J2 addition in mesangial cells: role in the inhibition of pro-inflammatory genes.

Sánchez-Gómez FJ, Cernuda-Morollón E, Stamatakis K, Pérez-Sala D. Sánchez-Gómez FJ, et al. Mol Pharmacol. 2004 Nov;66(5):1349-58. doi: 10.1124/mol.104.002824. Epub 2004 Aug 18. Mol Pharmacol. 2004. PMID: 15317873

Hydrogen-rich saline protects against liver injury in rats with obstructive jaundice.

Liu Q, Shen WF, Sun HY, Fan DF, Nakao A, Cai JM, Yan G, Zhou WP, Shen RX, Yang JM, Sun XJ. Liu Q, et al. Liver Int. 2010 Aug;30(7):958-68. doi: 10.1111/j.1478-3231.2010.02254.x. Epub 2010 May 21. Liver Int. 2010. PMID: 20492513

Nanomolar and micromolar effects of 15-deoxy-delta 12,14-prostaglandin J2 on amnion-derived WISH epithelial cells: differential roles of peroxisome proliferator-activated receptors gamma and delta and nuclear factor kappa B.

Berry EB, Keelan JA, Helliwell RJ, Gilmour RS, Mitchell MD. Berry EB, et al. Mol Pharmacol. 2005 Jul;68(1):169-78. doi: 10.1124/mol.104.009449. Epub 2005 Apr 8. Mol Pharmacol. 2005. PMID: 15821150

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