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THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo.

Mancini A, Niemann-Seyde SC, Pankow R, El Bounkari O, Klebba-Färber S, Koch A, Jaworska E, Spooncer E, Gruber AD, Whetton AD, Tamura T.

BMC Biol. 2010 Jan 5;8:1. doi: 10.1186/1741-7007-8-1.


THOC5, a member of the mRNA export complex, contributes to processing of a subset of wingless/integrated (Wnt) target mRNAs and integrity of the gut epithelial barrier.

Saran S, Tran DD, Klebba-Färber S, Moran-Losada P, Wiehlmann L, Koch A, Chopra H, Pabst O, Hoffmann A, Klopfleisch R, Tamura T.

BMC Cell Biol. 2013 Nov 22;14:51. doi: 10.1186/1471-2121-14-51.


Identification of mRNAs that are spliced but not exported to the cytoplasm in the absence of THOC5 in mouse embryo fibroblasts.

Guria A, Tran DD, Ramachandran S, Koch A, El Bounkari O, Dutta P, Hauser H, Tamura T.

RNA. 2011 Jun;17(6):1048-56. doi: 10.1261/rna.2607011. Epub 2011 Apr 27.


Transcriptional regulation of immediate-early gene response by THOC5, a member of mRNA export complex, contributes to the M-CSF-induced macrophage differentiation.

Tran DD, Saran S, Dittrich-Breiholz O, Williamson AJ, Klebba-Färber S, Koch A, Kracht M, Whetton AD, Tamura T.

Cell Death Dis. 2013 Oct 24;4:e879. doi: 10.1038/cddis.2013.409.


An ataxia-telangiectasia-mutated (ATM) kinase mediated response to DNA damage down-regulates the mRNA-binding potential of THOC5.

Ramachandran S, Tran DD, Klebba-Faerber S, Kardinal C, Whetton AD, Tamura T.

RNA. 2011 Nov;17(11):1957-66. doi: 10.1261/rna.2820911. Epub 2011 Sep 21.


Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA.

Katahira J, Inoue H, Hurt E, Yoneda Y.

EMBO J. 2009 Mar 4;28(5):556-67. doi: 10.1038/emboj.2009.5. Epub 2009 Jan 22.


The Thoc1 encoded ribonucleoprotein is required for myeloid progenitor cell homeostasis in the adult mouse.

Pitzonka L, Ullas S, Chinnam M, Povinelli BJ, Fisher DT, Golding M, Appenheimer MM, Nemeth MJ, Evans S, Goodrich DW.

PLoS One. 2014 May 15;9(5):e97628. doi: 10.1371/journal.pone.0097628. eCollection 2014.


FMIP controls the adipocyte lineage commitment of C2C12 cells by downmodulation of C/EBP alpha.

Mancini A, El Bounkari O, Norrenbrock AF, Scherr M, Schaefer D, Eder M, Banham AH, Pulford K, Lyne L, Whetton AD, Tamura T.

Oncogene. 2007 Feb 15;26(7):1020-7. Epub 2006 Aug 7.


Murine leukemia virus uses TREX components for efficient nuclear export of unspliced viral transcripts.

Sakuma T, Tonne JM, Ikeda Y.

Viruses. 2014 Mar 10;6(3):1135-48. doi: 10.3390/v6031135.


Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA.

Chi B, Wang Q, Wu G, Tan M, Wang L, Shi M, Chang X, Cheng H.

Nucleic Acids Res. 2013 Jan;41(2):1294-306. doi: 10.1093/nar/gks1188. Epub 2012 Dec 7.


Nuclear localization of the pre-mRNA associating protein THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein (FMIP).

El Bounkari O, Guria A, Klebba-Faerber S, Claussen M, Pieler T, Griffiths JR, Whetton AD, Koch A, Tamura T.

FEBS Lett. 2009 Jan 5;583(1):13-8. doi: 10.1016/j.febslet.2008.11.024. Epub 2008 Dec 4.


Hoxb4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells.

Brun AC, Björnsson JM, Magnusson M, Larsson N, Leveén P, Ehinger M, Nilsson E, Karlsson S.

Blood. 2004 Jun 1;103(11):4126-33. Epub 2004 Feb 12.


Acquired deficiency of A20 results in rapid apoptosis, systemic inflammation, and abnormal hematopoietic stem cell function.

Nagamachi A, Nakata Y, Ueda T, Yamasaki N, Ebihara Y, Tsuji K, Honda Z, Takubo K, Suda T, Oda H, Inaba T, Honda H.

PLoS One. 2014 Jan 31;9(1):e87425. doi: 10.1371/journal.pone.0087425. eCollection 2014.


Leukemic stromal hematopoietic microenvironment negatively regulates the normal hematopoiesis in mouse model of leukemia.

Basak P, Chatterjee S, Das P, Das M, Pereira JA, Dutta RK, Chaklader M, Chaudhuri S, Law S.

Chin J Cancer. 2010 Dec;29(12):969-79.


Human Flt3 is expressed at the hematopoietic stem cell and the granulocyte/macrophage progenitor stages to maintain cell survival.

Kikushige Y, Yoshimoto G, Miyamoto T, Iino T, Mori Y, Iwasaki H, Niiro H, Takenaka K, Nagafuji K, Harada M, Ishikawa F, Akashi K.

J Immunol. 2008 Jun 1;180(11):7358-67.


SCL is required for normal function of short-term repopulating hematopoietic stem cells.

Curtis DJ, Hall MA, Van Stekelenburg LJ, Robb L, Jane SM, Begley CG.

Blood. 2004 May 1;103(9):3342-8. Epub 2004 Jan 15.


Differential kinetics of primitive hematopoietic cells assayed in vitro and in vivo during serum-free suspension culture of CD34+ blood progenitor cells.

Möbest D, Goan SR, Junghahn I, Winkler J, Fichtner I, Hermann M, Becker M, de Lima-Hahn E, Henschler R.

Stem Cells. 1999;17(3):152-61.

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