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Items: 1 to 20 of 100

1.

Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application.

Jackson AL, Linsley PS.

Nat Rev Drug Discov. 2010 Jan;9(1):57-67. doi: 10.1038/nrd3010. Review.

PMID:
20043028
2.

Applying small RNA molecules to the directed treatment of human diseases: realizing the potential.

Pappas TC, Bader AG, Andruss BF, Brown D, Ford LP.

Expert Opin Ther Targets. 2008 Jan;12(1):115-27. Review.

PMID:
18076375
3.

The therapeutic potential of LNA-modified siRNAs: reduction of off-target effects by chemical modification of the siRNA sequence.

Fluiter K, Mook OR, Baas F.

Methods Mol Biol. 2009;487:189-203. doi: 10.1007/978-1-60327-547-7_9. Review.

PMID:
19301648
4.

Short interfering RNA (siRNA): tool or therapeutic?

Cejka D, Losert D, Wacheck V.

Clin Sci (Lond). 2006 Jan;110(1):47-58. Review.

PMID:
16336204
5.

New short interfering RNA-based therapies for glomerulonephritis.

Shimizu H, Fujita T.

Nat Rev Nephrol. 2011 May 24;7(7):407-15. doi: 10.1038/nrneph.2011.61. Review.

PMID:
21610682
6.

Development of new RNAi therapeutics.

Liu G, Wong-Staal F, Li QX.

Histol Histopathol. 2007 Feb;22(2):211-7. doi: 10.14670/HH-22.211. Review.

PMID:
17149694
7.

Running interference: prospects and obstacles to using small interfering RNAs as small molecule drugs.

Dykxhoorn DM, Lieberman J.

Annu Rev Biomed Eng. 2006;8:377-402. Review.

PMID:
16834561
8.

Silencing disease genes in the laboratory and the clinic.

Watts JK, Corey DR.

J Pathol. 2012 Jan;226(2):365-79. doi: 10.1002/path.2993. Epub 2011 Nov 9. Review.

9.

Preclinical and clinical development of siRNA-based therapeutics.

Ozcan G, Ozpolat B, Coleman RL, Sood AK, Lopez-Berestein G.

Adv Drug Deliv Rev. 2015 Jun 29;87:108-19. doi: 10.1016/j.addr.2015.01.007. Epub 2015 Feb 7. Review.

10.

Mechanisms of immune system activation in mammalians by small interfering RNA (siRNA).

Mansoori B, Mohammadi A, Shir Jang S, Baradaran B.

Artif Cells Nanomed Biotechnol. 2016 Nov;44(7):1589-96. doi: 10.3109/21691401.2015.1102738. Epub 2015 Oct 26. Review.

PMID:
26497011
11.

Applications of RNA interference: current state and prospects for siRNA-based strategies in vivo.

Aigner A.

Appl Microbiol Biotechnol. 2007 Aug;76(1):9-21. Epub 2007 Apr 25. Review.

PMID:
17457539
12.

Therapeutic face of RNAi: in vivo challenges.

Borna H, Imani S, Iman M, Azimzadeh Jamalkandi S.

Expert Opin Biol Ther. 2015 Feb;15(2):269-85. doi: 10.1517/14712598.2015.983070. Epub 2014 Nov 15. Review.

PMID:
25399911
13.

Small interfering RNA-based molecular therapy of cancers.

Guo W, Chen W, Yu W, Huang W, Deng W.

Chin J Cancer. 2013 Sep;32(9):488-93. doi: 10.5732/cjc.012.10280. Epub 2013 Jan 18. Review.

14.

RNAi-based drug discovery and its application to therapeutics.

Hokaiwado N, Takeshita F, Banas A, Ochiya T.

IDrugs. 2008 Apr;11(4):274-8.

PMID:
18379962
15.

Therapeutic gene silencing in neurological disorders, using interfering RNA.

Ralph GS, Mazarakis ND, Azzouz M.

J Mol Med (Berl). 2005 Jun;83(6):413-9. Epub 2005 Mar 10. Review.

PMID:
15759100
16.

Improving siRNA bio-distribution and minimizing side effects.

Scaggiante B, Dapas B, Farra R, Grassi M, Pozzato G, Giansante C, Fiotti N, Grassi G.

Curr Drug Metab. 2011 Jan;12(1):11-23. Review.

PMID:
21222588
17.

Nonviral in vivo delivery of therapeutic small interfering RNAs.

Aigner A.

Curr Opin Mol Ther. 2007 Aug;9(4):345-52. Review.

PMID:
17694447
18.

siRNA-based therapeutic approaches for rheumatic diseases.

Apparailly F, Jorgensen C.

Nat Rev Rheumatol. 2013 Jan;9(1):56-62. doi: 10.1038/nrrheum.2012.176. Epub 2012 Oct 23. Review.

PMID:
23090506
19.

Deciphering the code of innate immunity recognition of siRNAs.

Sioud M.

Methods Mol Biol. 2009;487:41-59. doi: 10.1007/978-1-60327-547-7_2. Review.

PMID:
19301641
20.

Targeted gene silencing by small interfering RNA-based knock-down technology.

Zhang J, Hua ZC.

Curr Pharm Biotechnol. 2004 Feb;5(1):1-7. Review.

PMID:
14965205

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