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Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration.

Jang YC, Lustgarten MS, Liu Y, Muller FL, Bhattacharya A, Liang H, Salmon AB, Brooks SV, Larkin L, Hayworth CR, Richardson A, Van Remmen H.

FASEB J. 2010 May;24(5):1376-90. doi: 10.1096/fj.09-146308. Epub 2009 Dec 29.


Dietary restriction attenuates age-associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD.

Jang YC, Liu Y, Hayworth CR, Bhattacharya A, Lustgarten MS, Muller FL, Chaudhuri A, Qi W, Li Y, Huang JY, Verdin E, Richardson A, Van Remmen H.

Aging Cell. 2012 Oct;11(5):770-82. doi: 10.1111/j.1474-9726.2012.00843.x. Epub 2012 Aug 2.


Neuron-specific expression of CuZnSOD prevents the loss of muscle mass and function that occurs in homozygous CuZnSOD-knockout mice.

Sakellariou GK, Davis CS, Shi Y, Ivannikov MV, Zhang Y, Vasilaki A, Macleod GT, Richardson A, Van Remmen H, Jackson MJ, McArdle A, Brooks SV.

FASEB J. 2014 Apr;28(4):1666-81. doi: 10.1096/fj.13-240390. Epub 2013 Dec 30.


The lack of CuZnSOD leads to impaired neurotransmitter release, neuromuscular junction destabilization and reduced muscle strength in mice.

Shi Y, Ivannikov MV, Walsh ME, Liu Y, Zhang Y, Jaramillo CA, Macleod GT, Van Remmen H.

PLoS One. 2014 Jun 27;9(6):e100834. doi: 10.1371/journal.pone.0100834. eCollection 2014.


Destabilization of the neuromuscular junction by proteolytic cleavage of agrin results in precocious sarcopenia.

Bütikofer L, Zurlinden A, Bolliger MF, Kunz B, Sonderegger P.

FASEB J. 2011 Dec;25(12):4378-93. doi: 10.1096/fj.11-191262. Epub 2011 Sep 1.


Reduced TrkB expression results in precocious age-like changes in neuromuscular structure, neurotransmission, and muscle function.

Kulakowski SA, Parker SD, Personius KE.

J Appl Physiol (1985). 2011 Sep;111(3):844-52. doi: 10.1152/japplphysiol.00070.2011. Epub 2011 Jul 7.


Skeletal muscle weakness due to deficiency of CuZn-superoxide dismutase is associated with loss of functional innervation.

Larkin LM, Davis CS, Sims-Robinson C, Kostrominova TY, Van Remmen H, Richardson A, Feldman EL, Brooks SV.

Am J Physiol Regul Integr Comp Physiol. 2011 Nov;301(5):R1400-7. doi: 10.1152/ajpregu.00093.2011. Epub 2011 Sep 7.


Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy.

Muller FL, Song W, Liu Y, Chaudhuri A, Pieke-Dahl S, Strong R, Huang TT, Epstein CJ, Roberts LJ 2nd, Csete M, Faulkner JA, Van Remmen H.

Free Radic Biol Med. 2006 Jun 1;40(11):1993-2004. Epub 2006 Feb 17.


Conditional knockout of Mn-SOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity.

Lustgarten MS, Jang YC, Liu Y, Muller FL, Qi W, Steinhelper M, Brooks SV, Larkin L, Shimizu T, Shirasawa T, McManus LM, Bhattacharya A, Richardson A, Van Remmen H.

Am J Physiol Cell Physiol. 2009 Dec;297(6):C1520-32. doi: 10.1152/ajpcell.00372.2009. Epub 2009 Sep 23.


Striking denervation of neuromuscular junctions without lumbar motoneuron loss in geriatric mouse muscle.

Chai RJ, Vukovic J, Dunlop S, Grounds MD, Shavlakadze T.

PLoS One. 2011;6(12):e28090. doi: 10.1371/journal.pone.0028090. Epub 2011 Dec 2.


Signaling and aging at the neuromuscular synapse: lessons learnt from neuromuscular diseases.

Punga AR, Ruegg MA.

Curr Opin Pharmacol. 2012 Jun;12(3):340-6. doi: 10.1016/j.coph.2012.02.002. Epub 2012 Feb 23. Review.


Elevated hydrogen peroxide and decreased catalase and glutathione peroxidase protection are associated with aging sarcopenia.

Sullivan-Gunn MJ, Lewandowski PA.

BMC Geriatr. 2013 Oct 7;13:104. doi: 10.1186/1471-2318-13-104.


Overexpression of the mitochondrial T3 receptor induces skeletal muscle atrophy during aging.

Casas F, Pessemesse L, Grandemange S, Seyer P, Baris O, Gueguen N, Ramonatxo C, Perrin F, Fouret G, Lepourry L, Cabello G, Wrutniak-Cabello C.

PLoS One. 2009 May 20;4(5):e5631. doi: 10.1371/journal.pone.0005631.


Mechanisms Regulating Neuromuscular Junction Development and Function and Causes of Muscle Wasting.

Tintignac LA, Brenner HR, Rüegg MA.

Physiol Rev. 2015 Jul;95(3):809-52. doi: 10.1152/physrev.00033.2014. Review.


Age-associated alterations of the neuromuscular junction.

Jang YC, Van Remmen H.

Exp Gerontol. 2011 Feb-Mar;46(2-3):193-8. doi: 10.1016/j.exger.2010.08.029. Epub 2010 Sep 18. Review.


MnSOD deficiency results in elevated oxidative stress and decreased mitochondrial function but does not lead to muscle atrophy during aging.

Lustgarten MS, Jang YC, Liu Y, Qi W, Qin Y, Dahia PL, Shi Y, Bhattacharya A, Muller FL, Shimizu T, Shirasawa T, Richardson A, Van Remmen H.

Aging Cell. 2011 Jun;10(3):493-505. doi: 10.1111/j.1474-9726.2011.00695.x. Epub 2011 Apr 5.


Diaphragm muscle sarcopenia in aging mice.

Greising SM, Mantilla CB, Gorman BA, Ermilov LG, Sieck GC.

Exp Gerontol. 2013 Sep;48(9):881-7. doi: 10.1016/j.exger.2013.06.001. Epub 2013 Jun 19.


Accumulation of severely atrophic myofibers marks the acceleration of sarcopenia in slow and fast twitch muscles.

Rowan SL, Purves-Smith FM, Solbak NM, Hepple RT.

Exp Gerontol. 2011 Aug;46(8):660-9. doi: 10.1016/j.exger.2011.03.005. Epub 2011 Apr 12.


Alterations in mitochondrial function, hydrogen peroxide release and oxidative damage in mouse hind-limb skeletal muscle during aging.

Mansouri A, Muller FL, Liu Y, Ng R, Faulkner J, Hamilton M, Richardson A, Huang TT, Epstein CJ, Van Remmen H.

Mech Ageing Dev. 2006 Mar;127(3):298-306. Epub 2006 Jan 6.

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