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20033812,21998335,19949897,20972872,16110022,15117979,17695437,19273709,23034738,27853901,23943026,18722765,19797108,17426704,15800322,17228023,15944796,23276521,28983557,26527776,22071131,15309508,19833818,11350904,16299036,17868408,15380576,23754140,21863510,17179731,19661324,18469706,17430582,15749237,19242829,17265519,17075118,21597022,19565284,17504984,17460459,28040692,26775578,21036755,27009937,23481186,24019539,25474278,31268130,25361982,26271397,26031544,25956750,21205083,23195666,23204187,21422910,17943475,25889520,30527814,24512910,24889488,30399198,21129608,26123496,21107085,16675565,25919688,27821793,21996957,10644941,26382962,20307245,16952542,27051466,19321964,21898388,29153096,20431306,21677451,17026563,31816156,20498393,23342874,23392240,21621406,32791559,24394004,20632816,15375710,12445368,22311118,20387074,31980219,24331320,24448331,18594845,32162808,25620482,12237891,21615788,28006055,22732839,29921730,24630275,15557782,22433756,26797240,23575396,22305240,21791486,19203898,20172363,26702772,26839356,22156611,28688636,22968062,21397476,20723426,14961589,21651356,21603868,28585041,33028592,35058539,11040179,20083749,31206244,21679278,32599987,23871161,23314736,32058649,23045248,32085892,22452940,30119912,22189752,33316771,21087350,22967467,18836281,28241187,24859205,21224659,25154726,18279058,20079591,16710035,25012517,22842502,23137529,26796888,28651158,22110208,11596588,33341444,29187431,26471980,27355330,28707088,21107088,23996617,22915656,30415988,28328969,20560137,30806287,23649938,34677260,30804154,26859833,26768652,29167892,23446022,22353804,30421554,28455965,22067390,21664647,23652310,23571142,24220557,14960518,28067827,29620994,26702526,32822722,24188686,16331619,19444104,23313932,22493400,23425253,27370895,18949393,34801698,27742654,23268020,19628078,21692068,21747089,29130943,22534478,12867608,27881709,20665215,26471890,29486916,28522602,22722556,24639190,23040685,22203756,27046481,21442350,25743829,22214010,20737420,17187355,19931261,16721360,27857024,35227453,24048783,20507057,21585692,31307113,35900537,25985893,18172256,25824744,15510606,26375742,30894685,34933441,25884851,31060539,22115676,27067848,27699609,16731121,17241514,22147942,15212702,35412430,34515995,23633032,24173294,20429733,20037370,23104212,24127781,30314738,33465114,31285374,27748284,26054387,21918173,32079623,19019605,32697360,11998605,17991344,32599979,12525515,23536352,25475571,20578180,17009149,8204538,27955637,16724208,33580623,24222164,20526099,8562152,23228985,18798075,11309634,27857023,22082644,25310185,25614197,15626658,26224509,29727332,23172532,23726265,32762143,27210097,15720808,26697201,21805040,21302302,19183332,31500770,22184386,31099875,25294886,33356421,30878317,32294529,34403553,25238407,11182044,23587148,20526097,18759201,26809540,23232902,15826579,18457354,25996601,30396964,16317262,36716414,37042135,31798786,33030308,30650417,21768791,26156156,26467912,28676214,28709704,20398453,26320600,21810510,28104993,30679175,21766495,25179158,22234098,31970760,26163115,29496294,32360245,26786262,29299827,21479885,22330089,32923882,18039421,22839297,21319156,25595934,30077598,33159235,26799310,26790967,31356278,32710312,18208804,23332421,17192059,22076610,20190798,31607697,23243701,26035698,35174772,36319973,21803658,20516444,19997103,26187617,31549400,26496037,11802206,23288924,21416472,31427545,26002619,29367431,25704535,29784738,27624582,16389156,21829067,19597886,24412704,22859396,33675399,30253025,23983256,26142736,21197740,34906120,26071595,27210088,28341242,21068505,28601656,27067847,34796431,21964812,25864037,20679606,29755119,31166206,22020760,24710310,24654694,26520019,33020177,25731421,32785776,32729847,34052294,19728905,28063788,23243702,29686976,35952316,25841497,8682586,21768462,24518735,23690119,35596629,22833293,20716892,19923997,21855043,30543589,24852857,18661526,20186699,17879369,21732224,34936379,29362345,24980946,20643619,20953739,26027602,32839257,20090515,19343302,29187501,33449452,32785799,17303911,30665466,15577673,22902454,17009390,24166914,18523220,22441128,11289281,31043188,31564566,26498208,23478000,30737921,27994472,18494354,9457218,22886390,28742687,23102497,25529518,20153885,32638371,18357466,20841953,32449246,12196371,17531106,9291442,29277635,33747906,32425600,32057467,27798874,24944470,28133107,19276255,30989434,18830122,30003720,30623420,16483940,26239822,19810096,30666834,31885734,31513484,35405622,20406923,34218138,29674439,15619218,34485815,23438691,31938240,19427194,31986316,21996958,29983889,16929496,34202689,31810907,22806931,34282542,20923998,21792915,37129151,31500870,32165096,34198876,33654584,34889790,36469712,15555207,18765539,20937204,23295255,23933939,30499151,34625033,31804673,36217248,22412136,15045942,24351404,26731722,33586012,23295318,27977612,35565332,29297170,17374440,20440283,37036516,17016601,31424568,21912453,26805109,23422758,25227897,30646898,25430983,34677685,30898102,26193339,15452397,25731324,14514923,21816436,11586966,36650414,28957395,2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Page 1

Clinical impact of microsatellite instability in colon cancer following adjuvant FOLFOX therapy.

Kim ST, Lee J, Park SH, Park JO, Lim HY, Kang WK, Kim JY, Kim YH, Chang DK, Rhee PL, Kim DS, Yun H, Cho YB, Kim HC, Yun SH, Lee WY, Chun HK, Park YS. Kim ST, et al. Cancer Chemother Pharmacol. 2010 Sep;66(4):659-67. doi: 10.1007/s00280-009-1206-3. Epub 2009 Dec 24. Cancer Chemother Pharmacol. 2010. PMID: 20033812

Defective mismatch repair status as a prognostic biomarker of disease-free survival in stage III colon cancer patients treated with adjuvant FOLFOX chemotherapy.

Zaanan A, Fléjou JF, Emile JF, Des GG, Cuilliere-Dartigues P, Malka D, Lecaille C, Validire P, Louvet C, Rougier P, de Gramont A, Bonnetain F, Praz F, Taïeb J. Zaanan A, et al. Clin Cancer Res. 2011 Dec 1;17(23):7470-8. doi: 10.1158/1078-0432.CCR-11-1048. Epub 2011 Oct 13. Clin Cancer Res. 2011. PMID: 21998335

The effect of DNA mismatch repair (MMR) status on oxaliplatin-based first-line chemotherapy as in recurrent or metastatic colon cancer.

Kim ST, Lee J, Park SH, Park JO, Lim HY, Kang WK, Kim JY, Kim YH, Chang DK, Rhee PL, Kim DS, Yun H, Cho YB, Kim HC, Yun SH, Chun HK, Lee WY, Park YS. Kim ST, et al. Med Oncol. 2010 Dec;27(4):1277-85. doi: 10.1007/s12032-009-9374-x. Epub 2009 Dec 1. Med Oncol. 2010. PMID: 19949897

Clinical impact of K-ras mutation in colorectal cancer patients treated with adjuvant FOLFOX.

Chang MH, Lee IK, Si Y, Lee KS, Woo IS, Byun JH. Chang MH, et al. Cancer Chemother Pharmacol. 2011 Aug;68(2):317-23. doi: 10.1007/s00280-010-1496-5. Epub 2010 Oct 24. Cancer Chemother Pharmacol. 2011. PMID: 20972872

Determination of TP53 mutation is more relevant than microsatellite instability status for the prediction of disease-free survival in adjuvant-treated stage III colon cancer patients.

Westra JL, Schaapveld M, Hollema H, de Boer JP, Kraak MM, de Jong D, ter Elst A, Mulder NH, Buys CH, Hofstra RM, Plukker JT. Westra JL, et al. J Clin Oncol. 2005 Aug 20;23(24):5635-43. doi: 10.1200/JCO.2005.04.096. J Clin Oncol. 2005. PMID: 16110022 Clinical Trial.

Prognostic value of proliferation, apoptosis, defective DNA mismatch repair, and p53 overexpression in patients with resected Dukes' B2 or C colon cancer: a North Central Cancer Treatment Group Study.

Garrity MM, Burgart LJ, Mahoney MR, Windschitl HE, Salim M, Wiesenfeld M, Krook JE, Michalak JC, Goldberg RM, O'Connell MJ, Furth AF, Sargent DJ, Murphy LM, Hill E, Riehle DL, Meyers CH, Witzig TE; North Central Cancer Treatment Group. Garrity MM, et al. J Clin Oncol. 2004 May 1;22(9):1572-82. doi: 10.1200/JCO.2004.10.042. J Clin Oncol. 2004. PMID: 15117979

Microsatellite instability and sensitivitiy to FOLFOX treatment in metastatic colorectal cancer.

des Guetz G, Mariani P, Cucherousset J, Benamoun M, Lagorce C, Sastre X, Le Toumelin P, Uzzan B, Perret GY, Morere JF, Breau JL, Fagard R, Schischmanoff PO. des Guetz G, et al. Anticancer Res. 2007 Jul-Aug;27(4C):2715-9. Anticancer Res. 2007. PMID: 17695437

Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer: Cancer and Leukemia Group B Protocol 89803.

Bertagnolli MM, Niedzwiecki D, Compton CC, Hahn HP, Hall M, Damas B, Jewell SD, Mayer RJ, Goldberg RM, Saltz LB, Warren RS, Redston M. Bertagnolli MM, et al. J Clin Oncol. 2009 Apr 10;27(11):1814-21. doi: 10.1200/JCO.2008.18.2071. Epub 2009 Mar 9. J Clin Oncol. 2009. PMID: 19273709 Free PMC article. Clinical Trial.

Methylation and microsatellite status and recurrence following adjuvant FOLFOX in colorectal cancer.

Han SW, Lee HJ, Bae JM, Cho NY, Lee KH, Kim TY, Oh DY, Im SA, Bang YJ, Jeong SY, Park KJ, Park JG, Kang GH, Kim TY. Han SW, et al. Int J Cancer. 2013 May 1;132(9):2209-16. doi: 10.1002/ijc.27888. Epub 2012 Oct 29. Int J Cancer. 2013. PMID: 23034738 Free article.

Microsatellite Instability was not Associated with Survival in Stage III Colon Cancer Treated with Adjuvant Chemotherapy of Oxaliplatin and Infusional 5-Fluorouracil and Leucovorin (FOLFOX).

Kim JE, Hong YS, Kim HJ, Kim KP, Kim SY, Lim SB, Park IJ, Kim CW, Yoon YS, Yu CS, Kim JC, Kim JH, Kim TW. Kim JE, et al. Ann Surg Oncol. 2017 May;24(5):1289-1294. doi: 10.1245/s10434-016-5682-5. Epub 2016 Nov 16. Ann Surg Oncol. 2017. PMID: 27853901

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