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Items: 1 to 20 of 77

1.

JNK1 phosphorylates SIRT1 and promotes its enzymatic activity.

Nasrin N, Kaushik VK, Fortier E, Wall D, Pearson KJ, de Cabo R, Bordone L.

PLoS One. 2009 Dec 22;4(12):e8414. doi: 10.1371/journal.pone.0008414.

2.

Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity.

Gao Z, Zhang J, Kheterpal I, Kennedy N, Davis RJ, Ye J.

J Biol Chem. 2011 Jun 24;286(25):22227-34. doi: 10.1074/jbc.M111.228874. Epub 2011 May 3.

3.

CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage.

Kang H, Jung JW, Kim MK, Chung JH.

PLoS One. 2009 Aug 14;4(8):e6611. doi: 10.1371/journal.pone.0006611.

4.

DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1.

Guo X, Williams JG, Schug TT, Li X.

J Biol Chem. 2010 Apr 23;285(17):13223-32. doi: 10.1074/jbc.M110.102574. Epub 2010 Feb 18.

5.

JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases.

Hu MC, Qiu WR, Wang YP.

Oncogene. 1997 Nov 6;15(19):2277-87.

6.

The NAD(+)-dependent protein deacetylase activity of SIRT1 is regulated by its oligomeric status.

Guo X, Kesimer M, Tolun G, Zheng X, Xu Q, Lu J, Sheehan JK, Griffith JD, Li X.

Sci Rep. 2012;2:640. doi: 10.1038/srep00640. Epub 2012 Sep 7.

8.

Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1).

Liu X, Wang D, Zhao Y, Tu B, Zheng Z, Wang L, Wang H, Gu W, Roeder RG, Zhu WG.

Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):1925-30. doi: 10.1073/pnas.1019619108. Epub 2011 Jan 18.

9.

Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase.

Nin V, Escande C, Chini CC, Giri S, Camacho-Pereira J, Matalonga J, Lou Z, Chini EN.

J Biol Chem. 2012 Jul 6;287(28):23489-501. doi: 10.1074/jbc.M112.365874. Epub 2012 May 2.

10.

Phosphorylation regulates SIRT1 function.

Sasaki T, Maier B, Koclega KD, Chruszcz M, Gluba W, Stukenberg PT, Minor W, Scrable H.

PLoS One. 2008;3(12):e4020. doi: 10.1371/journal.pone.0004020. Epub 2008 Dec 24.

11.

mIGF-1/JNK1/SirT1 signaling confers protection against oxidative stress in the heart.

Vinciguerra M, Santini MP, Martinez C, Pazienza V, Claycomb WC, Giuliani A, Rosenthal N.

Aging Cell. 2012 Feb;11(1):139-49. doi: 10.1111/j.1474-9726.2011.00766.x. Epub 2011 Dec 11.

12.

SIRT1 negatively regulates the activities, functions, and protein levels of hMOF and TIP60.

Peng L, Ling H, Yuan Z, Fang B, Bloom G, Fukasawa K, Koomen J, Chen J, Lane WS, Seto E.

Mol Cell Biol. 2012 Jul;32(14):2823-36. doi: 10.1128/MCB.00496-12. Epub 2012 May 14.

13.

A novel retro-inverso peptide is a preferential JNK substrate-competitive inhibitor.

Ngoei KR, Catimel B, Milech N, Watt PM, Bogoyevitch MA.

Int J Biochem Cell Biol. 2013 Aug;45(8):1939-50. doi: 10.1016/j.biocel.2013.06.006. Epub 2013 Jun 19.

PMID:
23792175
14.

c-Jun N-terminal kinase 1 promotes transforming growth factor-β1-induced epithelial-to-mesenchymal transition via control of linker phosphorylation and transcriptional activity of Smad3.

Velden JL, Alcorn JF, Guala AS, Badura EC, Janssen-Heininger YM.

Am J Respir Cell Mol Biol. 2011 Apr;44(4):571-81. doi: 10.1165/rcmb.2009-0282OC. Epub 2010 Jun 25.

15.

SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation.

Vaquero A, Scher M, Erdjument-Bromage H, Tempst P, Serrano L, Reinberg D.

Nature. 2007 Nov 15;450(7168):440-4.

PMID:
18004385
16.

Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1.

Fröjdö S, Durand C, Molin L, Carey AL, El-Osta A, Kingwell BA, Febbraio MA, Solari F, Vidal H, Pirola L.

Mol Cell Endocrinol. 2011 Mar 30;335(2):166-76. doi: 10.1016/j.mce.2011.01.008. Epub 2011 Jan 15.

PMID:
21241768
17.

Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathway.

Chau MD, Gao J, Yang Q, Wu Z, Gromada J.

Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12553-8. doi: 10.1073/pnas.1006962107. Epub 2010 Jun 28.

18.

AROS has a context-dependent effect on SIRT1.

Kokkola T, Suuronen T, Molnár F, Määttä J, Salminen A, Jarho EM, Lahtela-Kakkonen M.

FEBS Lett. 2014 May 2;588(9):1523-8. doi: 10.1016/j.febslet.2014.03.020. Epub 2014 Mar 26.

19.

MST1 promotes apoptosis through regulating Sirt1-dependent p53 deacetylation.

Yuan F, Xie Q, Wu J, Bai Y, Mao B, Dong Y, Bi W, Ji G, Tao W, Wang Y, Yuan Z.

J Biol Chem. 2011 Mar 4;286(9):6940-5. doi: 10.1074/jbc.M110.182543. Epub 2011 Jan 6.

20.

Peptide switch is essential for Sirt1 deacetylase activity.

Kang H, Suh JY, Jung YS, Jung JW, Kim MK, Chung JH.

Mol Cell. 2011 Oct 21;44(2):203-13. doi: 10.1016/j.molcel.2011.07.038.

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