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Items: 1 to 20 of 201

1.

Small-molecule modulators of the Sonic Hedgehog signaling pathway.

Stanton BZ, Peng LF.

Mol Biosyst. 2010 Jan;6(1):44-54. doi: 10.1039/b910196a. Epub 2009 Aug 27. Review.

PMID:
20024066
2.

Impact of the Smoothened inhibitor, IPI-926, on smoothened ciliary localization and Hedgehog pathway activity.

Peluso MO, Campbell VT, Harari JA, Tibbitts TT, Proctor JL, Whitebread N, Conley JM, White KF, Kutok JL, Read MA, McGovern K, Faia KL.

PLoS One. 2014 Mar 7;9(3):e90534. doi: 10.1371/journal.pone.0090534. eCollection 2014.

3.

Targeting hedgehog signaling pathway in pediatric tumors: in vitro evaluation of SMO and GLI inhibitors.

Arnhold V, Boos J, Lanvers-Kaminsky C.

Cancer Chemother Pharmacol. 2016 Mar;77(3):495-505. doi: 10.1007/s00280-016-2962-5. Epub 2016 Jan 19.

PMID:
26781311
4.

Targeting of the Hedgehog signal transduction pathway suppresses survival of malignant pleural mesothelioma cells in vitro.

You M, Varona-Santos J, Singh S, Robbins DJ, Savaraj N, Nguyen DM.

J Thorac Cardiovasc Surg. 2014 Jan;147(1):508-16. doi: 10.1016/j.jtcvs.2013.08.035. Epub 2013 Oct 4.

5.

miR-326 is downstream of Sonic hedgehog signaling and regulates the expression of Gli2 and smoothened.

Jiang Z, Cushing L, Ai X, Lü J.

Am J Respir Cell Mol Biol. 2014 Aug;51(2):273-83. doi: 10.1165/rcmb.2013-0127OC.

6.

Advances in Smoothened-targeting therapies for pancreatic cancer: implication for drug discovery from herbal medicines.

Han JB, Hua YQ, Chen LY, Liu LM.

Zhong Xi Yi Jie He Xue Bao. 2012 Mar;10(3):256-63. Review.

7.

Targeting the hedgehog signaling pathway with small molecules.

Kiselyov AS.

Anticancer Agents Med Chem. 2006 Sep;6(5):445-9. Review.

PMID:
17017853
8.

TAK-441, a novel investigational smoothened antagonist, delays castration-resistant progression in prostate cancer by disrupting paracrine hedgehog signaling.

Ibuki N, Ghaffari M, Pandey M, Iu I, Fazli L, Kashiwagi M, Tojo H, Nakanishi O, Gleave ME, Cox ME.

Int J Cancer. 2013 Oct 15;133(8):1955-66. doi: 10.1002/ijc.28193. Epub 2013 May 6.

9.

Protein kinase A activation inhibits oncogenic Sonic hedgehog signalling and suppresses basal cell carcinoma of the skin.

Makinodan E, Marneros AG.

Exp Dermatol. 2012 Nov;21(11):847-52. doi: 10.1111/exd.12016.

PMID:
23163650
10.

Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo.

Wickström M, Dyberg C, Shimokawa T, Milosevic J, Baryawno N, Fuskevåg OM, Larsson R, Kogner P, Zaphiropoulos PG, Johnsen JI.

Int J Cancer. 2013 Apr 1;132(7):1516-24. doi: 10.1002/ijc.27820. Epub 2012 Oct 3.

11.

Hedgehog signaling drives cellular survival in human colon carcinoma cells.

Mazumdar T, DeVecchio J, Shi T, Jones J, Agyeman A, Houghton JA.

Cancer Res. 2011 Feb 1;71(3):1092-102. doi: 10.1158/0008-5472.CAN-10-2315. Epub 2010 Dec 6.

12.

Sonic hedgehog signaling drives proliferation of synoviocytes in rheumatoid arthritis: a possible novel therapeutic target.

Wang M, Zhu S, Peng W, Li Q, Li Z, Luo M, Feng X, Lin Z, Huang J.

J Immunol Res. 2014;2014:401903. doi: 10.1155/2014/401903. Epub 2014 Mar 6.

13.

Smoothened as a new therapeutic target for human osteosarcoma.

Hirotsu M, Setoguchi T, Sasaki H, Matsunoshita Y, Gao H, Nagao H, Kunigou O, Komiya S.

Mol Cancer. 2010 Jan 12;9:5. doi: 10.1186/1476-4598-9-5.

14.

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists.

Frank-Kamenetsky M, Zhang XM, Bottega S, Guicherit O, Wichterle H, Dudek H, Bumcrot D, Wang FY, Jones S, Shulok J, Rubin LL, Porter JA.

J Biol. 2002 Nov 6;1(2):10.

15.

Hedgehog signaling pathway and gastric cancer.

Katoh Y, Katoh M.

Cancer Biol Ther. 2005 Oct;4(10):1050-4. Epub 2005 Oct 18. Review.

PMID:
16258256
16.

Sonic hedgehog signaling plays an essential role during embryonic salivary gland epithelial branching morphogenesis.

Jaskoll T, Leo T, Witcher D, Ormestad M, Astorga J, Bringas P Jr, Carlsson P, Melnick M.

Dev Dyn. 2004 Apr;229(4):722-32.

17.

Activation of the Sonic Hedgehog pathway in thyroid neoplasms and its potential role in tumor cell proliferation.

Xu X, Ding H, Rao G, Arora S, Saclarides CP, Esparaz J, Gattuso P, Solorzano CC, Prinz RA.

Endocr Relat Cancer. 2012 Apr 10;19(2):167-79. doi: 10.1530/ERC-11-0305. Print 2012 Apr.

18.

Hedgehog-signaling is upregulated in non-producing human adrenal adenomas and antagonism of hedgehog-signaling inhibits proliferation of NCI-H295R cells and an immortalized primary human adrenal cell line.

Werminghaus P, Haase M, Hornsby PJ, Schinner S, Schott M, Malendowicz LK, Lammers BJ, Goretzki PE, Müller-Mattheis V, Markus Giessing, Willenberg HS.

J Steroid Biochem Mol Biol. 2014 Jan;139:7-15. doi: 10.1016/j.jsbmb.2013.09.007. Epub 2013 Sep 21.

PMID:
24063979
19.

LKB1 inhibits breast cancer partially through repressing the Hedgehog signaling pathway.

Zhuang Z, Wang K, Cheng X, Qu X, Jiang B, Li Z, Luo J, Shao Z, Duan T.

PLoS One. 2013 Jul 4;8(7):e67431. doi: 10.1371/journal.pone.0067431. Print 2013.

20.

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

Yauch RL, Dijkgraaf GJ, Alicke B, Januario T, Ahn CP, Holcomb T, Pujara K, Stinson J, Callahan CA, Tang T, Bazan JF, Kan Z, Seshagiri S, Hann CL, Gould SE, Low JA, Rudin CM, de Sauvage FJ.

Science. 2009 Oct 23;326(5952):572-4. doi: 10.1126/science.1179386. Epub 2009 Sep 2.

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