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Items: 1 to 20 of 140

1.

A role for Chk2 in DNA damage induced mitotic delays in human colorectal cancer cells.

Varmark H, Kwak S, Theurkauf WE.

Cell Cycle. 2010 Jan 15;9(2):312-20. Epub 2010 Jan 23.

PMID:
20023427
2.

DNA damage-induced S phase arrest in human breast cancer depends on Chk1, but G2 arrest can occur independently of Chk1, Chk2 or MAPKAPK2.

Zhang WH, Poh A, Fanous AA, Eastman A.

Cell Cycle. 2008 Jun 1;7(11):1668-77. Epub 2008 Mar 23.

PMID:
18469532
3.
4.

Chk1 and Chk2 are differentially involved in homologous recombination repair and cell cycle arrest in response to DNA double-strand breaks induced by camptothecins.

Huang M, Miao ZH, Zhu H, Cai YJ, Lu W, Ding J.

Mol Cancer Ther. 2008 Jun;7(6):1440-9. doi: 10.1158/1535-7163.MCT-07-2116.

5.

CHK1 and CHK2 are differentially involved in mismatch repair-mediated 6-thioguanine-induced cell cycle checkpoint responses.

Yan T, Desai AB, Jacobberger JW, Sramkoski RM, Loh T, Kinsella TJ.

Mol Cancer Ther. 2004 Sep;3(9):1147-57.

6.
7.

Chk2 is required for optimal mitotic delay in response to irradiation-induced DNA damage incurred in G2 phase.

Rainey MD, Black EJ, Zachos G, Gillespie DA.

Oncogene. 2008 Feb 7;27(7):896-906. Epub 2007 Aug 6.

PMID:
17684483
8.

Phosphorylation of Plk1 at S137 and T210 is inhibited in response to DNA damage.

Tsvetkov L, Stern DF.

Cell Cycle. 2005 Jan;4(1):166-71. Epub 2005 Jan 5.

PMID:
15611664
9.

Determinants of mitotic catastrophe on abrogation of the G2 DNA damage checkpoint by UCN-01.

On KF, Chen Y, Ma HT, Chow JP, Poon RY.

Mol Cancer Ther. 2011 May;10(5):784-94. doi: 10.1158/1535-7163.MCT-10-0809. Epub 2011 Mar 23.

10.

grp (chk1) replication-checkpoint mutations and DNA damage trigger a Chk2-dependent block at the Drosophila midblastula transition.

Takada S, Kwak S, Koppetsch BS, Theurkauf WE.

Development. 2007 May;134(9):1737-44. Epub 2007 Apr 4.

11.

The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe.

Castedo M, Perfettini JL, Roumier T, Yakushijin K, Horne D, Medema R, Kroemer G.

Oncogene. 2004 May 27;23(25):4353-61.

PMID:
15048074
12.

DNA damage-induced mitotic catastrophe is mediated by the Chk1-dependent mitotic exit DNA damage checkpoint.

Huang X, Tran T, Zhang L, Hatcher R, Zhang P.

Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1065-70. Epub 2005 Jan 13.

13.

p53-dependent Chk1 phosphorylation is required for maintenance of prolonged G2 Arrest.

Wang XQ, Stanbridge EJ, Lao X, Cai Q, Fan ST, Redpath JL.

Radiat Res. 2007 Dec;168(6):706-15.

PMID:
18088187
14.

Grp/DChk1 is required for G2-M checkpoint activation in Drosophila S2 cells, whereas Dmnk/DChk2 is dispensable.

de Vries HI, Uyetake L, Lemstra W, Brunsting JF, Su TT, Kampinga HH, Sibon OC.

J Cell Sci. 2005 May 1;118(Pt 9):1833-42.

17.
18.

Cadmium-induced DNA damage triggers G(2)/M arrest via chk1/2 and cdc2 in p53-deficient kidney proximal tubule cells.

Bork U, Lee WK, Kuchler A, Dittmar T, Thévenod F.

Am J Physiol Renal Physiol. 2010 Feb;298(2):F255-65. doi: 10.1152/ajprenal.00273.2009. Epub 2009 Nov 18.

19.

Inhibition of Eg5 acts synergistically with checkpoint abrogation in promoting mitotic catastrophe.

Chen Y, Chow JP, Poon RY.

Mol Cancer Res. 2012 May;10(5):626-35. doi: 10.1158/1541-7786.MCR-11-0491. Epub 2012 Apr 20.

20.

Naphthalimides induce G(2) arrest through the ATM-activated Chk2-executed pathway in HCT116 cells.

Zhu H, Miao ZH, Huang M, Feng JM, Zhang ZX, Lu JJ, Cai YJ, Tong LJ, Xu YF, Qian XH, Ding J.

Neoplasia. 2009 Nov;11(11):1226-34.

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