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Items: 1 to 20 of 106

1.

Inositol 1,4,5-trisphosphate 3-kinase-A is a new cell motility-promoting protein that increases the metastatic potential of tumor cells by two functional activities.

Windhorst S, Fliegert R, Blechner C, Möllmann K, Hosseini Z, Günther T, Eiben M, Chang L, Lin HY, Fanick W, Schumacher U, Brandt B, Mayr GW.

J Biol Chem. 2010 Feb 19;285(8):5541-54. doi: 10.1074/jbc.M109.047050. Epub 2009 Dec 17.

2.

Functional role of inositol-1,4,5-trisphosphate-3-kinase-A for motility of malignant transformed cells.

Windhorst S, Kalinina T, Schmid K, Blechner C, Kriebitzsch N, Hinsch R, Chang L, Herich L, Schumacher U, Mayr GW.

Int J Cancer. 2011 Sep 15;129(6):1300-9. doi: 10.1002/ijc.25782. Epub 2011 Jan 6.

3.

The catalytic domain of inositol-1,4,5-trisphosphate 3-kinase-a contributes to ITPKA-induced modulation of F-actin.

Ashour DJ, Pelka B, Jaaks P, Wundenberg T, Blechner C, Zobiak B, Failla AV, Windhorst S.

Cytoskeleton (Hoboken). 2015 Feb;72(2):93-100. doi: 10.1002/cm.21208. Epub 2015 Feb 7.

PMID:
25620569
4.

Inositol-1,4,5-trisphosphate 3-kinase A regulates dendritic morphology and shapes synaptic Ca2+ transients.

Windhorst S, Minge D, Bähring R, Hüser S, Schob C, Blechner C, Lin HY, Mayr GW, Kindler S.

Cell Signal. 2012 Mar;24(3):750-7. doi: 10.1016/j.cellsig.2011.11.010. Epub 2011 Nov 18.

PMID:
22120525
5.

Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) is frequently over-expressed and functions as an oncogene in several tumor types.

Windhorst S, Song K, Gazdar AF.

Biochem Pharmacol. 2017 Aug 1;137:1-9. doi: 10.1016/j.bcp.2017.03.023. Epub 2017 Apr 2. Review.

PMID:
28377279
6.

Regulation of NGF-driven neurite outgrowth by Ins(1,4,5)P3 kinase is specifically associated with the two isoenzymes Itpka and Itpkb in a model of PC12 cells.

Koenig S, Moreau C, Dupont G, Scoumanne A, Erneux C.

FEBS J. 2015 Jul;282(13):2553-69. doi: 10.1111/febs.13300. Epub 2015 May 7.

7.

Identification of a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A.

Schröder D, Rehbach C, Seyffarth C, Neuenschwander M, Kries JV, Windhorst S.

Biochem Biophys Res Commun. 2013 Sep 20;439(2):228-34. doi: 10.1016/j.bbrc.2013.08.053. Epub 2013 Aug 24.

PMID:
23981806
8.

Inositol(1,4,5)P3 3-kinase isoenzymes: Catalytic properties and importance of targeting to F-actin to understand function.

Erneux C, Ghosh S, Koenig S.

Adv Biol Regul. 2016 Jan;60:135-43. doi: 10.1016/j.jbior.2015.09.004. Epub 2015 Sep 26. Review.

PMID:
26446452
9.

Down-regulation of 1D-myo-inositol 1,4,5-trisphosphate 3-kinase A protein expression in oral squamous cell carcinoma.

Kato H, Uzawa K, Onda T, Kato Y, Saito K, Nakashima D, Ogawara K, Bukawa H, Yokoe H, Tanzawa H.

Int J Oncol. 2006 Apr;28(4):873-81.

PMID:
16525636
10.

Inositol-1,4,5-trisphosphate-3-kinase-A controls morphology of hippocampal dendritic spines.

Köster JD, Leggewie B, Blechner C, Brandt N, Fester L, Rune G, Schweizer M, Kindler S, Windhorst S.

Cell Signal. 2016 Jan;28(1):83-90. doi: 10.1016/j.cellsig.2015.10.016. Epub 2015 Oct 28.

PMID:
26519023
11.

Growth-arrest-specific 7C protein inhibits tumor metastasis via the N-WASP/FAK/F-actin and hnRNP U/β-TrCP/β-catenin pathways in lung cancer.

Tseng RC, Chang JW, Mao JS, Tsai CD, Wu PC, Lin CJ, Lu YL, Liao SY, Cheng HC, Hsu HS, Wang YC.

Oncotarget. 2015 Dec 29;6(42):44207-21. doi: 10.18632/oncotarget.6229.

12.

Inhibition of Cdc42-interacting protein 4 (CIP4) impairs osteosarcoma tumor progression.

Koshkina NV, Yang G, Kleinerman ES.

Curr Cancer Drug Targets. 2013 Jan;13(1):48-56.

PMID:
22920438
13.
14.

Expression Regulation of the Metastasis-Promoting Protein InsP3-Kinase-A in Tumor Cells.

Chang L, Schwarzenbach H, Meyer-Staeckling S, Brandt B, Mayr GW, Weitzel JM, Windhorst S.

Mol Cancer Res. 2011 Apr;9(4):497-506. doi: 10.1158/1541-7786.MCR-10-0556. Epub 2011 Apr 1.

15.

A Salmonella inositol polyphosphatase acts in conjunction with other bacterial effectors to promote host cell actin cytoskeleton rearrangements and bacterial internalization.

Zhou D, Chen LM, Hernandez L, Shears SB, Galán JE.

Mol Microbiol. 2001 Jan;39(2):248-59. Erratum in: Mol Microbiol 2001 Jun;40(6):1461.

16.

Elevated phosphatase of regenerating liver 3 (PRL-3) promotes cytoskeleton reorganization, cell migration and invasion in endometrial stromal cells from endometrioma.

Zhan H, Ma J, Ruan F, Bedaiwy MA, Peng B, Wu R, Lin J.

Hum Reprod. 2016 Apr;31(4):723-33. doi: 10.1093/humrep/dew015. Epub 2016 Feb 13.

PMID:
26874360
17.

Suppression of the invasive capacity of rat ascites hepatoma cells by knockdown of Slingshot or LIM kinase.

Horita Y, Ohashi K, Mukai M, Inoue M, Mizuno K.

J Biol Chem. 2008 Mar 7;283(10):6013-21. doi: 10.1074/jbc.M706538200. Epub 2008 Jan 1.

18.

Deletion of inositol hexakisphosphate kinase 1 (IP6K1) reduces cell migration and invasion, conferring protection from aerodigestive tract carcinoma in mice.

Jadav RS, Kumar D, Buwa N, Ganguli S, Thampatty SR, Balasubramanian N, Bhandari R.

Cell Signal. 2016 Aug;28(8):1124-36. doi: 10.1016/j.cellsig.2016.04.011. Epub 2016 Apr 30.

19.

p70 S6 kinase in the control of actin cytoskeleton dynamics and directed migration of ovarian cancer cells.

Ip CK, Cheung AN, Ngan HY, Wong AS.

Oncogene. 2011 May 26;30(21):2420-32. doi: 10.1038/onc.2010.615. Epub 2011 Jan 24.

PMID:
21258406
20.

Isoprenylated human brain type I inositol 1,4,5-trisphosphate 5-phosphatase controls Ca2+ oscillations induced by ATP in Chinese hamster ovary cells.

De Smedt F, Missiaen L, Parys JB, Vanweyenberg V, De Smedt H, Erneux C.

J Biol Chem. 1997 Jul 11;272(28):17367-75.

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