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Pharmacological blockade of the DP2 receptor inhibits cigarette smoke-induced inflammation, mucus cell metaplasia, and epithelial hyperplasia in the mouse lung.

Stebbins KJ, Broadhead AR, Baccei CS, Scott JM, Truong YP, Coate H, Stock NS, Santini AM, Fagan P, Prodanovich P, Bain G, Stearns BA, King CD, Hutchinson JH, Prasit P, Evans JF, Lorrain DS.

J Pharmacol Exp Ther. 2010 Mar;332(3):764-75. doi: 10.1124/jpet.109.161919. Epub 2009 Dec 8.


Therapeutic efficacy of AM156, a novel prostanoid DP2 receptor antagonist, in murine models of allergic rhinitis and house dust mite-induced pulmonary inflammation.

Stebbins KJ, Broadhead AR, Correa LD, Scott JM, Truong YP, Stearns BA, Hutchinson JH, Prasit P, Evans JF, Lorrain DS.

Eur J Pharmacol. 2010 Jul 25;638(1-3):142-9. doi: 10.1016/j.ejphar.2010.04.031. Epub 2010 May 4.


DP2 (CRTh2) antagonism reduces ocular inflammation induced by allergen challenge and respiratory syncytial virus.

Stebbins KJ, Broadhead AR, Musiyenko A, Barik S, Scott JM, Truong YP, Stearns BA, Hutchinson JH, Prasit P, Evans JF, Lorrain DS.

Int Arch Allergy Immunol. 2012;157(3):259-68. doi: 10.1159/000328769. Epub 2011 Oct 28.


Pharmacology of AM211, a potent and selective prostaglandin D2 receptor type 2 antagonist that is active in animal models of allergic inflammation.

Bain G, Lorrain DS, Stebbins KJ, Broadhead AR, Santini AM, Prodanovich P, Darlington J, King CD, Lee C, Baccei C, Stearns B, Troung Y, Hutchinson JH, Prasit P, Evans JF.

J Pharmacol Exp Ther. 2011 Jul;338(1):290-301. doi: 10.1124/jpet.111.180430. Epub 2011 Apr 12.


Effects of prostaglandin D2, 15-deoxy-Delta12,14-prostaglandin J2, and selective DP1 and DP2 receptor agonists on pulmonary infiltration of eosinophils in Brown Norway rats.

Almishri W, Cossette C, Rokach J, Martin JG, Hamid Q, Powell WS.

J Pharmacol Exp Ther. 2005 Apr;313(1):64-9. Epub 2004 Dec 8.


Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation.

Uller L, Mathiesen JM, Alenmyr L, Korsgren M, Ulven T, Högberg T, Andersson G, Persson CG, Kostenis E.

Respir Res. 2007 Feb 28;8:16.


Differential modulation of human basophil functions through prostaglandin D2 receptors DP and chemoattractant receptor-homologous molecule expressed on Th2 cells/DP2.

Yoshimura-Uchiyama C, Iikura M, Yamaguchi M, Nagase H, Ishii A, Matsushima K, Yamamoto K, Shichijo M, Bacon KB, Hirai K.

Clin Exp Allergy. 2004 Aug;34(8):1283-90.


Pharmacologic profile of OC000459, a potent, selective, and orally active D prostanoid receptor 2 antagonist that inhibits mast cell-dependent activation of T helper 2 lymphocytes and eosinophils.

Pettipher R, Vinall SL, Xue L, Speight G, Townsend ER, Gazi L, Whelan CJ, Armer RE, Payton MA, Hunter MG.

J Pharmacol Exp Ther. 2012 Feb;340(2):473-82. doi: 10.1124/jpet.111.187203. Epub 2011 Nov 21.


Chronic obstructive pulmonary disease and neutrophil infiltration: role of cigarette smoke and cyclooxygenase products.

Profita M, Sala A, Bonanno A, Riccobono L, Ferraro M, La Grutta S, Albano GD, Montalbano AM, Gjomarkaj M.

Am J Physiol Lung Cell Mol Physiol. 2010 Feb;298(2):L261-9. doi: 10.1152/ajplung.90593.2008. Epub 2009 Nov 6.


Cigarette smoke-induced pulmonary inflammation and emphysema are attenuated in CCR6-deficient mice.

Bracke KR, D'hulst AI, Maes T, Moerloose KB, Demedts IK, Lebecque S, Joos GF, Brusselle GG.

J Immunol. 2006 Oct 1;177(7):4350-9.


Inflammatory cells and chronic obstructive pulmonary disease.

Tetley TD.

Curr Drug Targets Inflamm Allergy. 2005 Dec;4(6):607-18. Review.


Persistence of lung CD8 T cell oligoclonal expansions upon smoking cessation in a mouse model of cigarette smoke-induced emphysema.

Motz GT, Eppert BL, Sun G, Wesselkamper SC, Linke MJ, Deka R, Borchers MT.

J Immunol. 2008 Dec 1;181(11):8036-43.


Remodeling in response to infection and injury. Airway inflammation and hypersecretion of mucus in smoking subjects with chronic obstructive pulmonary disease.

Maestrelli P, Saetta M, Mapp CE, Fabbri LM.

Am J Respir Crit Care Med. 2001 Nov 15;164(10 Pt 2):S76-80. Review.


Activation of the prostaglandin D2 receptor DP2/CRTH2 increases allergic inflammation in mouse.

Spik I, Brénuchon C, Angéli V, Staumont D, Fleury S, Capron M, Trottein F, Dombrowicz D.

J Immunol. 2005 Mar 15;174(6):3703-8.


Prostaglandin D2 inhibits airway dendritic cell migration and function in steady state conditions by selective activation of the D prostanoid receptor 1.

Hammad H, de Heer HJ, Soullie T, Hoogsteden HC, Trottein F, Lambrecht BN.

J Immunol. 2003 Oct 15;171(8):3936-40.


Prostaglandin H2 induces the migration of human eosinophils through the chemoattractant receptor homologous molecule of Th2 cells, CRTH2.

Schuligoi R, Sedej M, Waldhoer M, Vukoja A, Sturm EM, Lippe IT, Peskar BA, Heinemann A.

J Leukoc Biol. 2009 Jan;85(1):136-45. doi: 10.1189/jlb.0608387. Epub 2008 Oct 3.


Non-allergic models of mucous cell metaplasia and mucus hypersecretion in rat nasal and pulmonary airways.

Harkema JR, Wagner JG.

Novartis Found Symp. 2002;248:181-97; discussion 197-200, 277-82. Review.


Role of neutrophils in mucus hypersecretion in COPD and implications for therapy.

Kim S, Nadel JA.

Treat Respir Med. 2004;3(3):147-59. Review.


Antagonists of the prostaglandin D2 receptor CRTH2.

Pettipher R, Hansel TT.

Drug News Perspect. 2008 Jul-Aug;21(6):317-22. doi: 10.1358/dnp.2008.21.6.1246831. Review.


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