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Items: 1 to 20 of 99

1.

Identification of triazinoindol-benzimidazolones as nanomolar inhibitors of the Mycobacterium tuberculosis enzyme TDP-6-deoxy-d-xylo-4-hexopyranosid-4-ulose 3,5-epimerase (RmlC).

Sivendran S, Jones V, Sun D, Wang Y, Grzegorzewicz AE, Scherman MS, Napper AD, McCammon JA, Lee RE, Diamond SL, McNeil M.

Bioorg Med Chem. 2010 Jan 15;18(2):896-908. doi: 10.1016/j.bmc.2009.11.033. Epub 2009 Nov 20.

2.

Benzimidazolones and indoles as non-thiol farnesyltransferase inhibitors based on tipifarnib scaffold: synthesis and activity.

Li Q, Li T, Woods KW, Gu WZ, Cohen J, Stoll VS, Galicia T, Hutchins C, Frost D, Rosenberg SH, Sham HL.

Bioorg Med Chem Lett. 2005 Jun 2;15(11):2918-22. Epub 2005 Apr 21.

PMID:
15911281
3.

Virtual screening for the identification of novel inhibitors of Mycobacterium tuberculosis cell wall synthesis: inhibitors targeting RmlB and RmlC.

Ren JX, Qian HL, Huang YX, Zhu NY, Si SY, Xie Y.

Comput Biol Med. 2015 Mar;58:110-7. doi: 10.1016/j.compbiomed.2014.12.020. Epub 2015 Jan 5.

PMID:
25637777
4.

High-throughput screen identifies small molecule inhibitors targeting acetyltransferase activity of Mycobacterium tuberculosis GlmU.

Rani C, Mehra R, Sharma R, Chib R, Wazir P, Nargotra A, Khan IA.

Tuberculosis (Edinb). 2015 Dec;95(6):664-77. doi: 10.1016/j.tube.2015.06.003. Epub 2015 Jul 31.

PMID:
26318557
5.

Inhibitors of the salicylate synthase (MbtI) from Mycobacterium tuberculosis discovered by high-throughput screening.

Vasan M, Neres J, Williams J, Wilson DJ, Teitelbaum AM, Remmel RP, Aldrich CC.

ChemMedChem. 2010 Dec 3;5(12):2079-87. doi: 10.1002/cmdc.201000275.

6.

Mycobacterium tuberculosis RmlC epimerase (Rv3465): a promising drug-target structure in the rhamnose pathway.

Kantardjieff KA, Kim CY, Naranjo C, Waldo GS, Lekin T, Segelke BW, Zemla A, Park MS, Terwilliger TC, Rupp B.

Acta Crystallogr D Biol Crystallogr. 2004 May;60(Pt 5):895-902. Epub 2004 Apr 21.

PMID:
15103135
7.
8.

A facile hydroxyindole carboxylic acid based focused library approach for potent and selective inhibitors of Mycobacterium protein tyrosine phosphatase B.

Zeng LF, Xu J, He Y, He R, Wu L, Gunawan AM, Zhang ZY.

ChemMedChem. 2013 Jun;8(6):904-8. doi: 10.1002/cmdc.201300115. Epub 2013 Apr 8.

9.

AlCl3 mediated unexpected migration of sulfonyl groups: regioselective synthesis of 7-sulfonyl indoles of potential pharmacological interest.

Prasad B, Adepu R, Sandra S, Rambabu D, Krishna GR, Reddy CM, Deora GS, Misra P, Pal M.

Chem Commun (Camb). 2012 Oct 28;48(84):10434-6. Epub 2012 Sep 19.

PMID:
22990283
10.

Discovery of a new class of inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B by biology-oriented synthesis.

Nören-Müller A, Wilk W, Saxena K, Schwalbe H, Kaiser M, Waldmann H.

Angew Chem Int Ed Engl. 2008;47(32):5973-7. doi: 10.1002/anie.200801566. No abstract available.

PMID:
18604796
11.

High-resolution structures of RmlC from Streptococcus suis in complex with substrate analogs locate the active site of this class of enzyme.

Dong C, Major LL, Allen A, Blankenfeldt W, Maskell D, Naismith JH.

Structure. 2003 Jun;11(6):715-23.

12.

Indole and benzimidazole derivatives as steroid 5alpha-reductase inhibitors in the rat prostate.

Takami H, Kishibayashi N, Ishii A, Kumazawa T.

Bioorg Med Chem. 1998 Dec;6(12):2441-8.

PMID:
9925300
13.

RmlC, the third enzyme of dTDP-L-rhamnose pathway, is a new class of epimerase.

Giraud MF, Leonard GA, Field RA, Berlind C, Naismith JH.

Nat Struct Biol. 2000 May;7(5):398-402.

PMID:
10802738
14.

Design, synthesis and evaluation of new GEQ derivatives as inhibitors of InhA enzyme and Mycobacterium tuberculosis growth.

Chollet A, Mori G, Menendez C, Rodriguez F, Fabing I, Pasca MR, Madacki J, Korduláková J, Constant P, Quémard A, Bernardes-Génisson V, Lherbet C, Baltas M.

Eur J Med Chem. 2015 Aug 28;101:218-35. doi: 10.1016/j.ejmech.2015.06.035. Epub 2015 Jun 20.

PMID:
26142487
15.

Synthesis and Antitumor Evaluation of Novel 5-Hydrosulfonyl-1H-benzo[d]imidazol-2(3H)-one Derivatives.

Ouyang G, Tong R, Li J, Bai L, Ouyang L, Duan X, Li F, He P, Shi J, He Y.

Molecules. 2016 Apr 20;21(4):516. doi: 10.3390/molecules21040516.

16.

Synthesis, biological screening and molecular modeling studies of novel 3-chloro-4-substituted-1-(2-(1H-benzimidazol-2-yl)phenyl))-azetidin-2-ones.

Chhajed SS, Upasani CD.

J Enzyme Inhib Med Chem. 2012 Aug;27(4):504-8. doi: 10.3109/14756366.2011.598867. Epub 2011 Aug 8.

PMID:
21823835
17.

Identification and development of 2-methylimidazo[1,2-a]pyridine-3-carboxamides as Mycobacterium tuberculosis pantothenate synthetase inhibitors.

Samala G, Nallangi R, Devi PB, Saxena S, Yadav R, Sridevi JP, Yogeeswari P, Sriram D.

Bioorg Med Chem. 2014 Aug 1;22(15):4223-32. doi: 10.1016/j.bmc.2014.05.038. Epub 2014 May 23.

PMID:
24953948
18.

Structure and in silico substrate-binding mode of ADP-L-glycero-D-manno-heptose 6-epimerase from Burkholderia thailandensis.

Kim MS, Lim A, Yang SW, Park J, Lee D, Shin DH.

Acta Crystallogr D Biol Crystallogr. 2013 Apr;69(Pt 4):658-68. doi: 10.1107/S0907444913001030. Epub 2013 Mar 14.

PMID:
23519675
19.

NAD+-dependent DNA ligase (Rv3014c) from Mycobacterium tuberculosis: novel structure-function relationship and identification of a specific inhibitor.

Srivastava SK, Dube D, Kukshal V, Jha AK, Hajela K, Ramachandran R.

Proteins. 2007 Oct 1;69(1):97-111.

PMID:
17557328
20.

Synthesis of various 3-nitropropionamides as Mycobacterium tuberculosis isocitrate lyase inhibitor.

Sriram D, Yogeeswari P, Methuku S, Vyas DR, Senthilkumar P, Alvala M, Jeankumar VU.

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5149-54. doi: 10.1016/j.bmcl.2011.07.062. Epub 2011 Jul 26.

PMID:
21840711

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