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Items: 1 to 20 of 116

1.

Deletion of Atoh1 disrupts Sonic Hedgehog signaling in the developing cerebellum and prevents medulloblastoma.

Flora A, Klisch TJ, Schuster G, Zoghbi HY.

Science. 2009 Dec 4;326(5958):1424-7. doi: 10.1126/science.1181453. Erratum in: Science. 2010 Mar 19;327(5972):1454.

2.

Post-transcriptional down-regulation of Atoh1/Math1 by bone morphogenic proteins suppresses medulloblastoma development.

Zhao H, Ayrault O, Zindy F, Kim JH, Roussel MF.

Genes Dev. 2008 Mar 15;22(6):722-7. doi: 10.1101/gad.1636408.

3.

Atoh1 inhibits neuronal differentiation and collaborates with Gli1 to generate medulloblastoma-initiating cells.

Ayrault O, Zhao H, Zindy F, Qu C, Sherr CJ, Roussel MF.

Cancer Res. 2010 Jul 1;70(13):5618-27. doi: 10.1158/0008-5472.CAN-09-3740. Epub 2010 Jun 1.

4.
5.

Expression of Sonic hedgehog during cell proliferation in the human cerebellum.

Haldipur P, Bharti U, Govindan S, Sarkar C, Iyengar S, Gressens P, Mani S.

Stem Cells Dev. 2012 May 1;21(7):1059-68. doi: 10.1089/scd.2011.0206. Epub 2011 Aug 24.

PMID:
21732818
6.

Insulin receptor substrate 1 is an effector of sonic hedgehog mitogenic signaling in cerebellar neural precursors.

Parathath SR, Mainwaring LA, Fernandez-L A, Campbell DO, Kenney AM.

Development. 2008 Oct;135(19):3291-300. doi: 10.1242/dev.022871. Epub 2008 Aug 28.

7.

Shh signaling protects Atoh1 from degradation mediated by the E3 ubiquitin ligase Huwe1 in neural precursors.

Forget A, Bihannic L, Cigna SM, Lefevre C, Remke M, Barnat M, Dodier S, Shirvani H, Mercier A, Mensah A, Garcia M, Humbert S, Taylor MD, Lasorella A, Ayrault O.

Dev Cell. 2014 Jun 23;29(6):649-61. doi: 10.1016/j.devcel.2014.05.014.

8.

Dual and opposing roles of primary cilia in medulloblastoma development.

Han YG, Kim HJ, Dlugosz AA, Ellison DW, Gilbertson RJ, Alvarez-Buylla A.

Nat Med. 2009 Sep;15(9):1062-5. doi: 10.1038/nm.2020. Epub 2009 Aug 23.

9.

Distinct roles for fibroblast growth factor signaling in cerebellar development and medulloblastoma.

Emmenegger BA, Hwang EI, Moore C, Markant SL, Brun SN, Dutton JW, Read TA, Fogarty MP, Singh AR, Durden DL, Yang C, McKeehan WL, Wechsler-Reya RJ.

Oncogene. 2013 Aug 29;32(35):4181-8. doi: 10.1038/onc.2012.440. Epub 2012 Oct 8.

10.

Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma.

Briggs KJ, Corcoran-Schwartz IM, Zhang W, Harcke T, Devereux WL, Baylin SB, Eberhart CG, Watkins DN.

Genes Dev. 2008 Mar 15;22(6):770-85. doi: 10.1101/gad.1640908. Erratum in: Genes Dev. 2008 May 15;22(10):1410.

11.

The p53 inhibitor MDM2 facilitates Sonic Hedgehog-mediated tumorigenesis and influences cerebellar foliation.

Malek R, Matta J, Taylor N, Perry ME, Mendrysa SM.

PLoS One. 2011 Mar 18;6(3):e17884. doi: 10.1371/journal.pone.0017884.

12.

Interferon-gamma induced medulloblastoma in the developing cerebellum.

Lin W, Kemper A, McCarthy KD, Pytel P, Wang JP, Campbell IL, Utset MF, Popko B.

J Neurosci. 2004 Nov 10;24(45):10074-83.

13.

Suppressor of fused controls mid-hindbrain patterning and cerebellar morphogenesis via GLI3 repressor.

Kim JJ, Gill PS, Rotin L, van Eede M, Henkelman RM, Hui CC, Rosenblum ND.

J Neurosci. 2011 Feb 2;31(5):1825-36. doi: 10.1523/JNEUROSCI.2166-10.2011.

14.

Nos2 inactivation promotes the development of medulloblastoma in Ptch1(+/-) mice by deregulation of Gap43-dependent granule cell precursor migration.

Haag D, Zipper P, Westrich V, Karra D, Pfleger K, Toedt G, Blond F, Delhomme N, Hahn M, Reifenberger J, Reifenberger G, Lichter P.

PLoS Genet. 2012;8(3):e1002572. doi: 10.1371/journal.pgen.1002572. Epub 2012 Mar 15.

15.
16.

Sonic hedgehog-associated medulloblastoma arising from the cochlear nuclei of the brainstem.

Grammel D, Warmuth-Metz M, von Bueren AO, Kool M, Pietsch T, Kretzschmar HA, Rowitch DH, Rutkowski S, Pfister SM, Schüller U.

Acta Neuropathol. 2012 Apr;123(4):601-14. doi: 10.1007/s00401-012-0961-0. Epub 2012 Feb 21.

PMID:
22349907
17.

Hh and Wnt signaling regulate formation of olig2+ neurons in the zebrafish cerebellum.

McFarland KA, Topczewska JM, Weidinger G, Dorsky RI, Appel B.

Dev Biol. 2008 Jun 1;318(1):162-71. doi: 10.1016/j.ydbio.2008.03.016. Epub 2008 Mar 21.

18.

An integrated approach identifies Nhlh1 and Insm1 as Sonic Hedgehog-regulated genes in developing cerebellum and medulloblastoma.

De Smaele E, Fragomeli C, Ferretti E, Pelloni M, Po A, Canettieri G, Coni S, Di Marcotullio L, Greco A, Moretti M, Di Rocco C, Pazzaglia S, Maroder M, Screpanti I, Giannini G, Gulino A.

Neoplasia. 2008 Jan;10(1):89-98.

19.

Hedgehog-mediated regulation of PPARγ controls metabolic patterns in neural precursors and shh-driven medulloblastoma.

Bhatia B, Potts CR, Guldal C, Choi S, Korshunov A, Pfister S, Kenney AM, Nahlé ZA.

Acta Neuropathol. 2012 Apr;123(4):587-600. doi: 10.1007/s00401-012-0968-6. Epub 2012 Mar 11.

20.

In vivo Atoh1 targetome reveals how a proneural transcription factor regulates cerebellar development.

Klisch TJ, Xi Y, Flora A, Wang L, Li W, Zoghbi HY.

Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3288-93. doi: 10.1073/pnas.1100230108. Epub 2011 Feb 7.

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