Format
Sort by

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 96

1.

Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis.

Sandanayaka V, Mamat B, Mishra RK, Winger J, Krohn M, Zhou LM, Keyvan M, Enache L, Sullins D, Onua E, Zhang J, Halldorsdottir G, Sigthorsdottir H, Thorlaksdottir A, Sigthorsson G, Thorsteinnsdottir M, Davies DR, Stewart LJ, Zembower DE, Andresson T, Kiselyov AS, Singh J, Gurney ME.

J Med Chem. 2010 Jan 28;53(2):573-85. doi: 10.1021/jm900838g.

PMID:
19950900
2.

Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase.

Kirkland TA, Adler M, Bauman JG, Chen M, Haeggström JZ, King B, Kochanny MJ, Liang AM, Mendoza L, Phillips GB, Thunnissen M, Trinh L, Whitlow M, Ye B, Ye H, Parkinson J, Guilford WJ.

Bioorg Med Chem. 2008 May 1;16(9):4963-83. doi: 10.1016/j.bmc.2008.03.042.

PMID:
18394906
3.

Discovery of novel leukotriene A4 hydrolase inhibitors based on piperidine and piperazine scaffolds.

Sandanayaka V, Mamat B, Bhagat N, Bedell L, Halldorsdottir G, Sigthorsdottir H, Andrésson T, Kiselyov A, Gurney M, Singh J.

Bioorg Med Chem Lett. 2010 May 1;20(9):2851-4. doi: 10.1016/j.bmcl.2010.03.047.

PMID:
20371179
4.

Structure-activity relationship studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A(4) (LTA(4)) hydrolase.

Penning TD, Chandrakumar NS, Chen BB, Chen HY, Desai BN, Djuric SW, Docter SH, Gasiecki AF, Haack RA, Miyashiro JM, Russell MA, Yu SS, Corley DG, Durley RC, Kilpatrick BF, Parnas BL, Askonas LJ, Gierse JK, Harding EI, Highkin MK, Kachur JF, Kim SH, Krivi GG, Villani-Price D, Pyla EY, Smith WG.

J Med Chem. 2000 Feb 24;43(4):721-35.

PMID:
10691697
5.
6.

Synthesis of potent leukotriene A(4) hydrolase inhibitors. Identification of 3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid.

Penning TD, Russell MA, Chen BB, Chen HY, Liang CD, Mahoney MW, Malecha JW, Miyashiro JM, Yu SS, Askonas LJ, Gierse JK, Harding EI, Highkin MK, Kachur JF, Kim SH, Villani-Price D, Pyla EY, Ghoreishi-Haack NS, Smith WG.

J Med Chem. 2002 Aug 1;45(16):3482-90.

PMID:
12139459
7.
8.

Synthesis of imidazopyridines and purines as potent inhibitors of leukotriene A4 hydrolase.

Penning TD, Chandrakumar NS, Desai BN, Djuric SW, Gasiecki AF, Malecha JW, Miyashiro JM, Russell MA, Askonas LJ, Gierse JK, Harding EI, Highkin MK, Kachur JF, Kim SH, Villani-Price D, Pyla EY, Ghoreishi-Haack NS, Smith WG.

Bioorg Med Chem Lett. 2003 Mar 24;13(6):1137-9.

PMID:
12643929
9.

Discovery of novel and potent aryl diamines as leukotriene A4 hydrolase inhibitors.

Khim SK, Bauman J, Evans J, Freeman B, King B, Kirkland T, Kochanny M, Lentz D, Liang A, Mendoza L, Phillips G, Tseng JL, Wei RG, Ye H, Yu L, Parkinson J, Guilford WJ.

Bioorg Med Chem Lett. 2008 Jul 15;18(14):3895-8. doi: 10.1016/j.bmcl.2008.06.041.

PMID:
18590959
10.

Overview of recent drug discovery approaches for new generation leukotriene A4 hydrolase inhibitors.

Calışkan B, Banoglu E.

Expert Opin Drug Discov. 2013 Jan;8(1):49-63. doi: 10.1517/17460441.2013.735228. Review.

PMID:
23095029
11.

Synthesis and biological evaluation of N-mercaptoacylproline and N-mercaptoacylthiazolidine-4-carboxylic acid derivatives as leukotriene A4 hydrolase inhibitors.

Enomoto H, Morikawa Y, Miyake Y, Tsuji F, Mizuchi M, Suhara H, Fujimura K, Horiuchi M, Ban M.

Bioorg Med Chem Lett. 2008 Aug 15;18(16):4529-32. doi: 10.1016/j.bmcl.2008.07.043.

PMID:
18674901
12.

Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography.

Davies DR, Mamat B, Magnusson OT, Christensen J, Haraldsson MH, Mishra R, Pease B, Hansen E, Singh J, Zembower D, Kim H, Kiselyov AS, Burgin AB, Gurney ME, Stewart LJ.

J Med Chem. 2009 Aug 13;52(15):4694-715. doi: 10.1021/jm900259h. Erratum in: J Med Chem. 2010 Mar 11;53(5):2330-1.

13.

Synthesis of N-alkyl glycine amides as potent inhibitors of leukotriene A4 hydrolase.

Ye B, Bauman J, Chen M, Davey D, Khim SK, King B, Kirkland T, Kochanny M, Liang A, Lentz D, May K, Mendoza L, Phillips G, Selchau V, Schlyer S, Tseng JL, Wei RG, Ye H, Parkinson J, Guilford WJ.

Bioorg Med Chem Lett. 2008 Jul 15;18(14):3891-4. doi: 10.1016/j.bmcl.2008.06.046.

PMID:
18586492
14.

Isolation and structure of leukotriene-A4 hydrolase inhibitor: 8(S)-amino-2(R)-methyl-7-oxononanoic acid produced by Streptomyces diastaticus.

Parnas BL, Durley RC, Rhoden EE, Kilpatrick BF, Makkar N, Thomas KE, Smith WG, Corley DG.

J Nat Prod. 1996 Oct;59(10):962-4.

PMID:
8904845
15.

Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.

Grice CA, Tays KL, Savall BM, Wei J, Butler CR, Axe FU, Bembenek SD, Fourie AM, Dunford PJ, Lundeen K, Coles F, Xue X, Riley JP, Williams KN, Karlsson L, Edwards JP.

J Med Chem. 2008 Jul 24;51(14):4150-69. doi: 10.1021/jm701575k.

PMID:
18588282
16.

Leukotriene A4 hydrolase: identification of a common carboxylate recognition site for the epoxide hydrolase and aminopeptidase substrates.

Rudberg PC, Tholander F, Andberg M, Thunnissen MM, Haeggström JZ.

J Biol Chem. 2004 Jun 25;279(26):27376-82.

17.

Cyclosporin A down-regulates the LTA4 hydrolase level in human keratinocyte cultures.

Iversen L, Svendsen M, Kragballe K.

Acta Derm Venereol. 1996 Nov;76(6):424-8.

PMID:
8982402
18.

Structure and catalytic mechanisms of leukotriene A4 hydrolase.

Haeggström JZ, Tholander F, Wetterholm A.

Prostaglandins Other Lipid Mediat. 2007 May;83(3):198-202. Review.

PMID:
17481555
19.

Pyrrolidine and piperidine analogues of SC-57461A as potent, orally active inhibitors of leukotriene A(4) hydrolase.

Penning TD, Chandrakumar NS, Desai BN, Djuric SW, Gasiecki AF, Liang CD, Miyashiro JM, Russell MA, Askonas LJ, Gierse JK, Harding EI, Highkin MK, Kachur JF, Kim SH, Villani-Price D, Pyla EY, Ghoreishi-Haack NS, Smith WG.

Bioorg Med Chem Lett. 2002 Dec 2;12(23):3383-6.

PMID:
12419366
20.

Discovery of antibacterial biotin carboxylase inhibitors by virtual screening and fragment-based approaches.

Mochalkin I, Miller JR, Narasimhan L, Thanabal V, Erdman P, Cox PB, Prasad JV, Lightle S, Huband MD, Stover CK.

ACS Chem Biol. 2009 Jun 19;4(6):473-83. doi: 10.1021/cb9000102.

PMID:
19413326
Items per page

Supplemental Content

Support Center