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SCAP is required for timely and proper myelin membrane synthesis.

Verheijen MH, Camargo N, Verdier V, Nadra K, de Preux Charles AS, Médard JJ, Luoma A, Crowther M, Inouye H, Shimano H, Chen S, Brouwers JF, Helms JB, Feltri ML, Wrabetz L, Kirschner D, Chrast R, Smit AB.

Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21383-8. doi: 10.1073/pnas.0905633106. Epub 2009 Nov 30.


Heat Shock Protein 90 Modulates Lipid Homeostasis by Regulating the Stability and Function of Sterol Regulatory Element-binding Protein (SREBP) and SREBP Cleavage-activating Protein.

Kuan YC, Hashidume T, Shibata T, Uchida K, Shimizu M, Inoue J, Sato R.

J Biol Chem. 2017 Feb 17;292(7):3016-3028. doi: 10.1074/jbc.M116.767277. Epub 2016 Dec 21.


SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation.

Matsuda M, Korn BS, Hammer RE, Moon YA, Komuro R, Horton JD, Goldstein JL, Brown MS, Shimomura I.

Genes Dev. 2001 May 15;15(10):1206-16.


Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N).

Korn BS, Shimomura I, Bashmakov Y, Hammer RE, Horton JD, Goldstein JL, Brown MS.

J Clin Invest. 1998 Dec 15;102(12):2050-60.


COPI-mediated retrieval of SCAP is crucial for regulating lipogenesis under basal and sterol-deficient conditions.

Takashima K, Saitoh A, Funabashi T, Hirose S, Yagi C, Nozaki S, Sato R, Shin HW, Nakayama K.

J Cell Sci. 2015 Aug 1;128(15):2805-15. doi: 10.1242/jcs.164137. Epub 2015 Jun 19.


Insulin-induced gene: a new regulator in lipid metabolism.

Dong XY, Tang SQ.

Peptides. 2010 Nov;31(11):2145-50. doi: 10.1016/j.peptides.2010.07.020. Epub 2010 Sep 15. Review.


Deletion of Scap in alveolar type II cells influences lung lipid homeostasis and identifies a compensatory role for pulmonary lipofibroblasts.

Besnard V, Wert SE, Stahlman MT, Postle AD, Xu Y, Ikegami M, Whitsett JA.

J Biol Chem. 2009 Feb 6;284(6):4018-30. doi: 10.1074/jbc.M805388200. Epub 2008 Dec 11.


High-fat diet ameliorates neurological deficits caused by defective astrocyte lipid metabolism.

Camargo N, Brouwers JF, Loos M, Gutmann DH, Smit AB, Verheijen MH.

FASEB J. 2012 Oct;26(10):4302-15. doi: 10.1096/fj.12-205807. Epub 2012 Jul 2.


Sterol regulatory element-binding protein (SREBP) cleavage regulates Golgi-to-endoplasmic reticulum recycling of SREBP cleavage-activating protein (SCAP).

Shao W, Espenshade PJ.

J Biol Chem. 2014 Mar 14;289(11):7547-57. doi: 10.1074/jbc.M113.545699. Epub 2014 Jan 29.


Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis.

Engelking LJ, Kuriyama H, Hammer RE, Horton JD, Brown MS, Goldstein JL, Liang G.

J Clin Invest. 2004 Apr;113(8):1168-75.


mTORC1 controls PNS myelination along the mTORC1-RXRγ-SREBP-lipid biosynthesis axis in Schwann cells.

Norrmén C, Figlia G, Lebrun-Julien F, Pereira JA, Trötzmüller M, Köfeler HC, Rantanen V, Wessig C, van Deijk AL, Smit AB, Verheijen MH, Rüegg MA, Hall MN, Suter U.

Cell Rep. 2014 Oct 23;9(2):646-60. doi: 10.1016/j.celrep.2014.09.001. Epub 2014 Oct 9.


Scap is required for sterol synthesis and crypt growth in intestinal mucosa.

McFarlane MR, Cantoria MJ, Linden AG, January BA, Liang G, Engelking LJ.

J Lipid Res. 2015 Aug;56(8):1560-71. doi: 10.1194/jlr.M059709. Epub 2015 Apr 20.


SREBPs: SREBP function in glia-neuron interactions.

Camargo N, Smit AB, Verheijen MH.

FEBS J. 2009 Feb;276(3):628-36. doi: 10.1111/j.1742-4658.2008.06808.x. Review.


PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus.

Xu D, Wang Z, Zhang Y, Jiang W, Pan Y, Song BL, Chen Y.

Nat Commun. 2015 Aug 27;6:8100. doi: 10.1038/ncomms9100.

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