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Downregulation of p53 by phosphatase of regenerating liver 3 is mediated by MDM2 and PIRH2.

Min SH, Kim DM, Heo YS, Kim HM, Kim IC, Yoo OJ.

Life Sci. 2010 Jan 2;86(1-2):66-72. doi: 10.1016/j.lfs.2009.11.010.


New p53 target, phosphatase of regenerating liver 1 (PRL-1) downregulates p53.

Min SH, Kim DM, Heo YS, Kim YI, Kim HM, Kim J, Han YM, Kim IC, Yoo OJ.

Oncogene. 2009 Jan 29;28(4):545-54. doi: 10.1038/onc.2008.409.


The metastasis-associated gene Prl-3 is a p53 target involved in cell-cycle regulation.

Basak S, Jacobs SB, Krieg AJ, Pathak N, Zeng Q, Kaldis P, Giaccia AJ, Attardi LD.

Mol Cell. 2008 May 9;30(3):303-14. doi: 10.1016/j.molcel.2008.04.002.


Phosphatase of regenerating liver-3 promotes migration and invasion by upregulating matrix metalloproteinases-7 in human colorectal cancer cells.

Lee SK, Han YM, Yun J, Lee CW, Shin DS, Ha YR, Kim J, Koh JS, Hong SH, Han DC, Kwon BM.

Int J Cancer. 2012 Aug 1;131(3):E190-203. doi: 10.1002/ijc.27381.


Differential response between the p53 ubiquitin-protein ligases Pirh2 and MdM2 following DNA damage in human cancer cells.

Duan W, Gao L, Wu X, Zhang Y, Otterson GA, Villalona-Calero MA.

Exp Cell Res. 2006 Oct 15;312(17):3370-8.


PRL-3 down-regulates PTEN expression and signals through PI3K to promote epithelial-mesenchymal transition.

Wang H, Quah SY, Dong JM, Manser E, Tang JP, Zeng Q.

Cancer Res. 2007 Apr 1;67(7):2922-6.


Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice.

Jung CR, Lim JH, Choi Y, Kim DG, Kang KJ, Noh SM, Im DS.

J Clin Invest. 2010 Dec;120(12):4493-506. doi: 10.1172/JCI42674.


Structural and functional comparison of the RING domains of two p53 E3 ligases, Mdm2 and Pirh2.

Shloush J, Vlassov JE, Engson I, Duan S, Saridakis V, Dhe-Paganon S, Raught B, Sheng Y, Arrowsmith CH.

J Biol Chem. 2011 Feb 11;286(6):4796-808. doi: 10.1074/jbc.M110.157669.


A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network.

Toledo F, Krummel KA, Lee CJ, Liu CW, Rodewald LW, Tang M, Wahl GM.

Cancer Cell. 2006 Apr;9(4):273-85.


Mdm2 links genotoxic stress and metabolism to p53.

Wang Z, Li B.

Protein Cell. 2010 Dec;1(12):1063-72. doi: 10.1007/s13238-010-0140-9. Review.


Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells.

Zhao K, Zhou Y, Qiao C, Ni T, Li Z, Wang X, Guo Q, Lu N, Wei L.

J Hematol Oncol. 2015 Apr 23;8:41. doi: 10.1186/s13045-015-0137-1.


Down-modulation of keratin 8 phosphorylation levels by PRL-3 contributes to colorectal carcinoma progression.

Mizuuchi E, Semba S, Kodama Y, Yokozaki H.

Int J Cancer. 2009 Apr 15;124(8):1802-10. doi: 10.1002/ijc.24111.


MicroRNA-339-5p inhibits colorectal tumorigenesis through regulation of the MDM2/p53 signaling.

Zhang C, Liu J, Wang X, Wu R, Lin M, Laddha SV, Yang Q, Chan CS, Feng Z.

Oncotarget. 2014 Oct 15;5(19):9106-17.


PRL tyrosine phosphatases regulate rho family GTPases to promote invasion and motility.

Fiordalisi JJ, Keller PJ, Cox AD.

Cancer Res. 2006 Mar 15;66(6):3153-61.


A selective phosphatase of regenerating liver phosphatase inhibitor suppresses tumor cell anchorage-independent growth by a novel mechanism involving p130Cas cleavage.

Daouti S, Li WH, Qian H, Huang KS, Holmgren J, Levin W, Reik L, McGady DL, Gillespie P, Perrotta A, Bian H, Reidhaar-Olson JF, Bliss SA, Olivier AR, Sergi JA, Fry D, Danho W, Ritland S, Fotouhi N, Heimbrook D, Niu H.

Cancer Res. 2008 Feb 15;68(4):1162-9. doi: 10.1158/0008-5472.CAN-07-2349.


MDM2-dependent downregulation of p21 and hnRNP K provides a switch between apoptosis and growth arrest induced by pharmacologically activated p53.

Enge M, Bao W, Hedström E, Jackson SP, Moumen A, Selivanova G.

Cancer Cell. 2009 Mar 3;15(3):171-83. doi: 10.1016/j.ccr.2009.01.019. Erratum in: Cancer Cell. 2009 Jul 7;16(1):79.


CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation.

Yang W, Rozan LM, McDonald ER 3rd, Navaraj A, Liu JJ, Matthew EM, Wang W, Dicker DT, El-Deiry WS.

J Biol Chem. 2007 Feb 2;282(5):3273-81.


PRL-3 suppresses c-Fos and integrin α2 expression in ovarian cancer cells.

Liu H, Al-aidaroos AQ, Wang H, Guo K, Li J, Zhang HF, Zeng Q.

BMC Cancer. 2013 Feb 18;13:80. doi: 10.1186/1471-2407-13-80.


The p53 paddy wagon: COP1, Pirh2 and MDM2 are found resisting apoptosis and growth arrest.

Corcoran CA, Huang Y, Sheikh MS.

Cancer Biol Ther. 2004 Aug;3(8):721-5.

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