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Items: 1 to 20 of 145

1.

Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 beta production.

Mielke LA, Elkins KL, Wei L, Starr R, Tsichlis PN, O'Shea JJ, Watford WT.

J Immunol. 2009 Dec 15;183(12):7984-93. doi: 10.4049/jimmunol.0901336.

2.

Pharmacological inhibition of TPL2/MAP3K8 blocks human cytotoxic T lymphocyte effector functions.

Chowdhury FZ, Estrada LD, Murray S, Forman J, Farrar JD.

PLoS One. 2014 Mar 18;9(3):e92187. doi: 10.1371/journal.pone.0092187. eCollection 2014.

3.

Tumor progression locus 2-dependent oxidative burst drives phosphorylation of extracellular signal-regulated kinase during TLR3 and 9 signaling.

Kuriakose T, Rada B, Watford WT.

J Biol Chem. 2014 Dec 26;289(52):36089-100. doi: 10.1074/jbc.M114.587121. Epub 2014 Nov 5.

4.

A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation.

Sugimoto K, Ohata M, Miyoshi J, Ishizaki H, Tsuboi N, Masuda A, Yoshikai Y, Takamoto M, Sugane K, Matsuo S, Shimada Y, Matsuguchi T.

J Clin Invest. 2004 Sep;114(6):857-66.

6.

Cot/Tpl2 regulates IL-23 p19 expression in LPS-stimulated macrophages through ERK activation.

Kakimoto K, Musikacharoen T, Chiba N, Bandow K, Ohnishi T, Matsuguchi T.

J Physiol Biochem. 2010 Mar;66(1):47-53. doi: 10.1007/s13105-010-0007-9. Epub 2010 Apr 20.

PMID:
20405269
7.

Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii.

Watford WT, Hissong BD, Durant LR, Yamane H, Muul LM, Kanno Y, Tato CM, Ramos HL, Berger AE, Mielke L, Pesu M, Solomon B, Frucht DM, Paul WE, Sher A, Jankovic D, Tsichlis PN, O'Shea JJ.

J Exp Med. 2008 Nov 24;205(12):2803-12. doi: 10.1084/jem.20081461. Epub 2008 Nov 10.

8.

The Tpl2 mutation Sluggish impairs type I IFN production and increases susceptibility to group B streptococcal disease.

Xiao N, Eidenschenk C, Krebs P, Brandl K, Blasius AL, Xia Y, Khovananth K, Smart NG, Beutler B.

J Immunol. 2009 Dec 15;183(12):7975-83. doi: 10.4049/jimmunol.0902718.

9.

MAP3K8 (TPL2/COT) affects obesity-induced adipose tissue inflammation without systemic effects in humans and in mice.

Ballak DB, van Essen P, van Diepen JA, Jansen H, Hijmans A, Matsuguchi T, Sparrer H, Tack CJ, Netea MG, Joosten LA, Stienstra R.

PLoS One. 2014 Feb 24;9(2):e89615. doi: 10.1371/journal.pone.0089615. eCollection 2014.

10.

Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis.

Jager J, Grémeaux T, Gonzalez T, Bonnafous S, Debard C, Laville M, Vidal H, Tran A, Gual P, Le Marchand-Brustel Y, Cormont M, Tanti JF.

Diabetes. 2010 Jan;59(1):61-70. doi: 10.2337/db09-0470. Epub 2009 Oct 6.

11.

Tumor Progression Locus 2 Promotes Induction of IFNλ, Interferon Stimulated Genes and Antigen-Specific CD8+ T Cell Responses and Protects against Influenza Virus.

Kuriakose T, Tripp RA, Watford WT.

PLoS Pathog. 2015 Aug 4;11(8):e1005038. doi: 10.1371/journal.ppat.1005038. eCollection 2015 Aug.

12.

Tumor progression locus 2/Cot is required for activation of extracellular regulated kinase in liver injury and toll-like receptor-induced TIMP-1 gene transcription in hepatic stellate cells in mice.

Perugorria MJ, Murphy LB, Fullard N, Chakraborty JB, Vyrla D, Wilson CL, Oakley F, Mann J, Mann DA.

Hepatology. 2013 Mar;57(3):1238-49. doi: 10.1002/hep.26108.

13.

Fas-mediated inflammatory response in Listeria monocytogenes infection.

Uchiyama R, Yonehara S, Tsutsui H.

J Immunol. 2013 Apr 15;190(8):4245-54. doi: 10.4049/jimmunol.1203059. Epub 2013 Mar 15.

14.

TPL-2-ERK1/2 signaling promotes host resistance against intracellular bacterial infection by negative regulation of type I IFN production.

McNab FW, Ewbank J, Rajsbaum R, Stavropoulos E, Martirosyan A, Redford PS, Wu X, Graham CM, Saraiva M, Tsichlis P, Chaussabel D, Ley SC, O'Garra A.

J Immunol. 2013 Aug 15;191(4):1732-43. doi: 10.4049/jimmunol.1300146. Epub 2013 Jul 10.

16.

Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice.

Seki E, Tsutsui H, Tsuji NM, Hayashi N, Adachi K, Nakano H, Futatsugi-Yumikura S, Takeuchi O, Hoshino K, Akira S, Fujimoto J, Nakanishi K.

J Immunol. 2002 Oct 1;169(7):3863-8.

17.

The receptor for the complement C3a anaphylatoxin (C3aR) provides host protection against Listeria monocytogenes-induced apoptosis.

Mueller-Ortiz SL, Morales JE, Wetsel RA.

J Immunol. 2014 Aug 1;193(3):1278-89. doi: 10.4049/jimmunol.1302787. Epub 2014 Jun 30.

18.

Cot/tpl2 participates in the activation of macrophages by adiponectin.

Sanz-Garcia C, Nagy LE, Lasunción MA, Fernandez M, Alemany S.

J Leukoc Biol. 2014 Jun;95(6):917-30. doi: 10.1189/jlb.0913486. Epub 2014 Feb 14.

19.

TPL2 kinase regulates the inflammatory milieu of the myeloma niche.

Hope C, Ollar SJ, Heninger E, Hebron E, Jensen JL, Kim J, Maroulakou I, Miyamoto S, Leith C, Yang DT, Callander N, Hematti P, Chesi M, Bergsagel PL, Asimakopoulos F.

Blood. 2014 May 22;123(21):3305-15. doi: 10.1182/blood-2014-02-554071. Epub 2014 Apr 10.

20.

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