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Interleukin-7 regulates Bim proapoptotic activity in peripheral T-cell survival.

Li WQ, Guszczynski T, Hixon JA, Durum SK.

Mol Cell Biol. 2010 Feb;30(3):590-600. doi: 10.1128/MCB.01006-09. Epub 2009 Nov 23.


IL-15 regulates Bcl-2 family members Bim and Mcl-1 through JAK/STAT and PI3K/AKT pathways in T cells.

Shenoy AR, Kirschnek S, Häcker G.

Eur J Immunol. 2014 Aug;44(8):2500-7. doi: 10.1002/eji.201344238. Epub 2014 Jun 10.


Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim sustains B lymphopoiesis in the absence of IL-7.

Huntington ND, Labi V, Cumano A, Vieira P, Strasser A, Villunger A, Di Santo JP, Alves NL.

Int Immunol. 2009 Jun;21(6):715-25. doi: 10.1093/intimm/dxp043. Epub 2009 May 19.


Bcl-2 allows effector and memory CD8+ T cells to tolerate higher expression of Bim.

Kurtulus S, Tripathi P, Moreno-Fernandez ME, Sholl A, Katz JD, Grimes HL, Hildeman DA.

J Immunol. 2011 May 15;186(10):5729-37. doi: 10.4049/jimmunol.1100102. Epub 2011 Mar 30.


The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner.

Kazi A, Sun J, Doi K, Sung SS, Takahashi Y, Yin H, Rodriguez JM, Becerril J, Berndt N, Hamilton AD, Wang HG, Sebti SM.

J Biol Chem. 2011 Mar 18;286(11):9382-92. doi: 10.1074/jbc.M110.203638. Epub 2010 Dec 9.


Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism.

Rahmani M, Aust MM, Attkisson E, Williams DC Jr, Ferreira-Gonzalez A, Grant S.

Cancer Res. 2013 Feb 15;73(4):1340-51. doi: 10.1158/0008-5472.CAN-12-1365. Epub 2012 Dec 12.


c-Myc dependent expression of pro-apoptotic Bim renders HER2-overexpressing breast cancer cells dependent on anti-apoptotic Mcl-1.

Campone M, Noël B, Couriaud C, Grau M, Guillemin Y, Gautier F, Gouraud W, Charbonnel C, Campion L, Jézéquel P, Braun F, Barré B, Coqueret O, Barillé-Nion S, Juin P.

Mol Cancer. 2011 Sep 7;10:110. doi: 10.1186/1476-4598-10-110.


Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1β-induced apoptosis via Bim/A1 imbalance.

Miani M, Barthson J, Colli ML, Brozzi F, Cnop M, Eizirik DL.

Cell Death Dis. 2013 Jul 4;4:e701. doi: 10.1038/cddis.2013.236.


Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim.

Jabbour AM, Heraud JE, Daunt CP, Kaufmann T, Sandow J, O'Reilly LA, Callus BA, Lopez A, Strasser A, Vaux DL, Ekert PG.

Cell Death Differ. 2009 Apr;16(4):555-63. doi: 10.1038/cdd.2008.179. Epub 2008 Dec 12.


ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL.

Ewings KE, Hadfield-Moorhouse K, Wiggins CM, Wickenden JA, Balmanno K, Gilley R, Degenhardt K, White E, Cook SJ.

EMBO J. 2007 Jun 20;26(12):2856-67. Epub 2007 May 24.


IL-15 modulates the balance between Bcl-2 and Bim via a Jak3/1-PI3K-Akt-ERK pathway to promote CD8αα+ intestinal intraepithelial lymphocyte survival.

Lai YG, Hou MS, Lo A, Huang ST, Huang YW, Yang-Yen HF, Liao NS.

Eur J Immunol. 2013 Sep;43(9):2305-16. doi: 10.1002/eji.201243026. Epub 2013 Jul 12.


Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1.

Huntington ND, Puthalakath H, Gunn P, Naik E, Michalak EM, Smyth MJ, Tabarias H, Degli-Esposti MA, Dewson G, Willis SN, Motoyama N, Huang DC, Nutt SL, Tarlinton DM, Strasser A.

Nat Immunol. 2007 Aug;8(8):856-63. Epub 2007 Jul 8.


Increased lymphocyte apoptosis in mouse models of colitis upon ABT-737 treatment is dependent upon BIM expression.

Lutz C, Mozaffari M, Tosevski V, Caj M, Cippà P, McRae BL, Graff CL, Rogler G, Fried M, Hausmann M.

Clin Exp Immunol. 2015 Aug;181(2):343-56. doi: 10.1111/cei.12635. Epub 2015 May 19.


Bim must be able to engage all pro-survival Bcl-2 family members for efficient tumor suppression.

Mérino D, Strasser A, Bouillet P.

Oncogene. 2012 Jul 12;31(28):3392-6. doi: 10.1038/onc.2011.508. Epub 2011 Nov 14.


The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells.

Bauer A, Villunger A, Labi V, Fischer SF, Strasser A, Wagner H, Schmid RM, Häcker G.

Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):10979-84. Epub 2006 Jul 10.


The imbalance between Bim and Mcl-1 expression controls the survival of human myeloma cells.

Gomez-Bougie P, Bataille R, Amiot M.

Eur J Immunol. 2004 Nov;34(11):3156-64.


Apoptosis induced by histone deacetylase inhibitors in leukemic cells is mediated by Bim and Noxa.

Inoue S, Riley J, Gant TW, Dyer MJ, Cohen GM.

Leukemia. 2007 Aug;21(8):1773-82. Epub 2007 May 24.


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