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Growth hormone stimulates the collagen synthesis in human tendon and skeletal muscle without affecting myofibrillar protein synthesis.

Doessing S, Heinemeier KM, Holm L, Mackey AL, Schjerling P, Rennie M, Smith K, Reitelseder S, Kappelgaard AM, Rasmussen MH, Flyvbjerg A, Kjaer M.

J Physiol. 2010 Jan 15;588(Pt 2):341-51. doi: 10.1113/jphysiol.2009.179325. Epub 2009 Nov 23.


GH receptor blocker administration and muscle-tendon collagen synthesis in humans.

Nielsen RH, Doessing S, Goto K, Holm L, Reitelseder S, Agergaard J, Schjerling P, Flyvberg A, Kjaer M.

Growth Horm IGF Res. 2011 Jun;21(3):140-5. doi: 10.1016/j.ghir.2011.03.006. Epub 2011 Apr 16.


Effect of growth hormone on aging connective tissue in muscle and tendon: gene expression, morphology, and function following immobilization and rehabilitation.

Boesen AP, Dideriksen K, Couppé C, Magnusson SP, Schjerling P, Boesen M, Aagaard P, Kjaer M, Langberg H.

J Appl Physiol (1985). 2014 Jan 15;116(2):192-203. doi: 10.1152/japplphysiol.01077.2013. Epub 2013 Nov 14.


Tendon and skeletal muscle matrix gene expression and functional responses to immobilisation and rehabilitation in young males: effect of growth hormone administration.

Boesen AP, Dideriksen K, Couppé C, Magnusson SP, Schjerling P, Boesen M, Kjaer M, Langberg H.

J Physiol. 2013 Dec 1;591(23):6039-52. doi: 10.1113/jphysiol.2013.261263. Epub 2013 Sep 30.


GH/IGF-I axis and matrix adaptation of the musculotendinous tissue to exercise in humans.

Heinemeier KM, Mackey AL, Doessing S, Hansen M, Bayer ML, Nielsen RH, Herchenhan A, Malmgaard-Clausen NM, Kjaer M.

Scand J Med Sci Sports. 2012 Aug;22(4):e1-7. doi: 10.1111/j.1600-0838.2012.01459.x. Epub 2012 Mar 19. Review.


GH and IGF1 levels are positively associated with musculotendinous collagen expression: experiments in acromegalic and GH deficiency patients.

Doessing S, Holm L, Heinemeier KM, Feldt-Rasmussen U, Schjerling P, Qvortrup K, Larsen JO, Nielsen RH, Flyvbjerg A, Kjaer M.

Eur J Endocrinol. 2010 Dec;163(6):853-62. doi: 10.1530/EJE-10-0818. Epub 2010 Sep 21.


Chronic alterations in growth hormone/insulin-like growth factor-I signaling lead to changes in mouse tendon structure.

Nielsen RH, Clausen NM, Schjerling P, Larsen JO, Martinussen T, List EO, Kopchick JJ, Kjaer M, Heinemeier KM.

Matrix Biol. 2014 Feb;34:96-104. doi: 10.1016/j.matbio.2013.09.005. Epub 2013 Sep 28.


Effect of administration of oral contraceptives in vivo on collagen synthesis in tendon and muscle connective tissue in young women.

Hansen M, Miller BF, Holm L, Doessing S, Petersen SG, Skovgaard D, Frystyk J, Flyvbjerg A, Koskinen S, Pingel J, Kjaer M, Langberg H.

J Appl Physiol (1985). 2009 Apr;106(4):1435-43. doi: 10.1152/japplphysiol.90933.2008. Epub 2008 Oct 9.


Local administration of growth hormone stimulates tendon collagen synthesis in elderly men.

Vestergaard P, Jørgensen JO, Olesen JL, Bosnjak E, Holm L, Frystyk J, Langberg H, Kjaer M, Hansen M.

J Appl Physiol (1985). 2012 Nov;113(9):1432-8. doi: 10.1152/japplphysiol.00816.2012. Epub 2012 Sep 6.


Coordinated collagen and muscle protein synthesis in human patella tendon and quadriceps muscle after exercise.

Miller BF, Olesen JL, Hansen M, Døssing S, Crameri RM, Welling RJ, Langberg H, Flyvbjerg A, Kjaer M, Babraj JA, Smith K, Rennie MJ.

J Physiol. 2005 Sep 15;567(Pt 3):1021-33. Epub 2005 Jul 7.


Relationship between serum IGF-1 and skeletal muscle IGF-1 mRNA expression to phosphocreatine recovery after exercise in obese men with reduced GH.

Hamarneh SR, Murphy CA, Shih CW, Frontera W, Torriani M, Irazoqui JE, Makimura H.

J Clin Endocrinol Metab. 2015 Feb;100(2):617-25. doi: 10.1210/jc.2014-2711. Epub 2014 Nov 6.


Expression of insulin-like growth factor I, insulin-like growth factor binding proteins, and collagen mRNA in mechanically loaded plantaris tendon.

Olesen JL, Heinemeier KM, Haddad F, Langberg H, Flyvbjerg A, Kjaer M, Baldwin KM.

J Appl Physiol (1985). 2006 Jul;101(1):183-8.


Growth hormone stimulates protein synthesis in bovine skeletal muscle cells without altering insulin-like growth factor-I mRNA expression.

Ge X, Yu J, Jiang H.

J Anim Sci. 2012 Apr;90(4):1126-33. doi: 10.2527/jas.2011-4358. Epub 2011 Nov 18.


Insulin-like growth factor I enhances collagen synthesis in engineered human tendon tissue.

Herchenhan A, Bayer ML, Eliasson P, Magnusson SP, Kjaer M.

Growth Horm IGF Res. 2015 Feb;25(1):13-9. doi: 10.1016/j.ghir.2014.09.001. Epub 2014 Sep 22.


Effect of unloading followed by reloading on expression of collagen and related growth factors in rat tendon and muscle.

Heinemeier KM, Olesen JL, Haddad F, Schjerling P, Baldwin KM, Kjaer M.

J Appl Physiol (1985). 2009 Jan;106(1):178-86. doi: 10.1152/japplphysiol.91092.2008. Epub 2008 Nov 6.


Growth hormone, insulin-like growth factors and their binding proteins in adult hemodialysis patients treated with recombinant human growth hormone.

Jensen PB, Hansen TB, Frystyk J, Ladefoged SD, Pedersen FB, Christiansen JS.

Clin Nephrol. 1999 Aug;52(2):103-9.


From mechanical loading to collagen synthesis, structural changes and function in human tendon.

Kjaer M, Langberg H, Heinemeier K, Bayer ML, Hansen M, Holm L, Doessing S, Kongsgaard M, Krogsgaard MR, Magnusson SP.

Scand J Med Sci Sports. 2009 Aug;19(4):500-10. doi: 10.1111/j.1600-0838.2009.00986.x. Review.


Growth hormone treatment prevents the decrease in insulin-like growth factor I gene expression in patients undergoing abdominal surgery.

Bjarnason R, Wickelgren R, Hermansson M, Hammarqvist F, Carlsson B, Carlsson LM.

J Clin Endocrinol Metab. 1998 May;83(5):1566-72.


Serum IGF-I levels and IGF-I gene splicing in muscle of healthy young males receiving rhGH.

Aperghis M, Velloso CP, Hameed M, Brothwood T, Bradley L, Bouloux PM, Harridge SD, Goldspink G.

Growth Horm IGF Res. 2009 Feb;19(1):61-7. doi: 10.1016/j.ghir.2008.07.002. Epub 2008 Sep 16.


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