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Integration of distinct intracellular signaling pathways at distal regulatory elements directs T-bet expression in human CD4+ T cells.

Placek K, Gasparian S, Coffre M, Maiella S, Sechet E, Bianchi E, Rogge L.

J Immunol. 2009 Dec 15;183(12):7743-51. doi: 10.4049/jimmunol.0803812.


IFN-alpha is not sufficient to drive Th1 development due to lack of stable T-bet expression.

Ramos HJ, Davis AM, George TC, Farrar JD.

J Immunol. 2007 Sep 15;179(6):3792-803.


Strength of TCR signal determines the costimulatory requirements for Th1 and Th2 CD4+ T cell differentiation.

Tao X, Constant S, Jorritsma P, Bottomly K.

J Immunol. 1997 Dec 15;159(12):5956-63.


Defective Th1 cytokine gene transcription in CD4+ and CD8+ T cells from Wiskott-Aldrich syndrome patients.

Trifari S, Sitia G, Aiuti A, Scaramuzza S, Marangoni F, Guidotti LG, Martino S, Saracco P, Notarangelo LD, Roncarolo MG, Dupré L.

J Immunol. 2006 Nov 15;177(10):7451-61.


Molecular pathway profiling of T lymphocyte signal transduction pathways; Th1 and Th2 genomic fingerprints are defined by TCR and CD28-mediated signaling.

Smeets RL, Fleuren WW, He X, Vink PM, Wijnands F, Gorecka M, Klop H, Bauerschmidt S, Garritsen A, Koenen HJ, Joosten I, Boots AM, Alkema W.

BMC Immunol. 2012 Mar 14;13:12. doi: 10.1186/1471-2172-13-12.


T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells.

Afkarian M, Sedy JR, Yang J, Jacobson NG, Cereb N, Yang SY, Murphy TL, Murphy KM.

Nat Immunol. 2002 Jun;3(6):549-57. Epub 2002 May 13.


STAT6 inhibits T-bet-independent Th1 cell differentiation.

Tamachi T, Takatori H, Fujiwara M, Hirose K, Maezawa Y, Kagami S, Suto A, Watanabe N, Iwamoto I, Nakajima H.

Biochem Biophys Res Commun. 2009 May 15;382(4):751-5. doi: 10.1016/j.bbrc.2009.03.101. Epub 2009 Mar 24.


T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription.

Usui T, Preiss JC, Kanno Y, Yao ZJ, Bream JH, O'Shea JJ, Strober W.

J Exp Med. 2006 Mar 20;203(3):755-66. Epub 2006 Mar 6. Erratum in: J Exp Med. 2006 Apr 17;203(4):1129.


Overlapping and distinct roles of STAT4 and T-bet in the regulation of T cell differentiation and allergic airway inflammation.

Furuta S, Kagami S, Tamachi T, Ikeda K, Fujiwara M, Suto A, Hirose K, Watanabe N, Saito Y, Iwamoto I, Nakajima H.

J Immunol. 2008 May 15;180(10):6656-62.


Instruction of naive CD4+ T-cell fate to T-bet expression and T helper 1 development: roles of T-cell receptor-mediated signals.

Ariga H, Shimohakamada Y, Nakada M, Tokunaga T, Kikuchi T, Kariyone A, Tamura T, Takatsu K.

Immunology. 2007 Oct;122(2):210-21. Epub 2007 May 9. Erratum in: Immunology. 2007 Nov;122(3):454.


CC-4047 promotes Th1 cell differentiation and reprograms polarized human Th2 cells by enhancing transcription factor T-bet.

Xu W, Celeridad M, Sankar S, Webb DR, Bennett BL.

Clin Immunol. 2008 Sep;128(3):392-9. doi: 10.1016/j.clim.2008.04.009. Epub 2008 Jun 20.


Intestinal irradiation and fibrosis in a Th1-deficient environment.

Linard C, Billiard F, Benderitter M.

Int J Radiat Oncol Biol Phys. 2012 Sep 1;84(1):266-73. doi: 10.1016/j.ijrobp.2011.11.027. Epub 2012 Feb 13.


Altered Th1 cell differentiation programming by CIITA deficiency.

Patel DR, Kaplan MH, Chang CH.

J Immunol. 2004 Nov 1;173(9):5501-8.


IL-2-inducible T-cell kinase modulates TH2-mediated allergic airway inflammation by suppressing IFN-γ in naive CD4+ T cells.

Kannan AK, Sahu N, Mohanan S, Mohinta S, August A.

J Allergy Clin Immunol. 2013 Oct;132(4):811-20.e1-5. doi: 10.1016/j.jaci.2013.04.033. Epub 2013 Jun 12.

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