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Rpe65 isomerase associates with membranes through an electrostatic interaction with acidic phospholipid headgroups.

Yuan Q, Kaylor JJ, Miu A, Bassilian S, Whitelegge JP, Travis GH.

J Biol Chem. 2010 Jan 8;285(2):988-99. doi: 10.1074/jbc.M109.025643. Epub 2009 Nov 5.


Role of LRAT on the retinoid isomerase activity and membrane association of Rpe65.

Jin M, Yuan Q, Li S, Travis GH.

J Biol Chem. 2007 Jul 20;282(29):20915-24. Epub 2007 May 15.


Analysis of the retinoid isomerase activities in the retinal pigment epithelium and retina.

Travis GH, Kaylor J, Yuan Q.

Methods Mol Biol. 2010;652:329-39. doi: 10.1007/978-1-60327-325-1_19.


Rpe65 is a retinyl ester binding protein that presents insoluble substrate to the isomerase in retinal pigment epithelial cells.

Mata NL, Moghrabi WN, Lee JS, Bui TV, Radu RA, Horwitz J, Travis GH.

J Biol Chem. 2004 Jan 2;279(1):635-43. Epub 2003 Oct 7.


Mutation of key residues of RPE65 abolishes its enzymatic role as isomerohydrolase in the visual cycle.

Redmond TM, Poliakov E, Yu S, Tsai JY, Lu Z, Gentleman S.

Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13658-63. Epub 2005 Sep 6.


Purified RPE65 shows isomerohydrolase activity after reassociation with a phospholipid membrane.

Nikolaeva O, Takahashi Y, Moiseyev G, Ma JX.

FEBS J. 2009 Jun;276(11):3020-30. doi: 10.1111/j.1742-4658.2009.07021.x. Epub 2009 Apr 20.


Importance of membrane structural integrity for RPE65 retinoid isomerization activity.

Golczak M, Kiser PD, Lodowski DT, Maeda A, Palczewski K.

J Biol Chem. 2010 Mar 26;285(13):9667-82. doi: 10.1074/jbc.M109.063941. Epub 2010 Jan 25.


Rpe65 is the retinoid isomerase in bovine retinal pigment epithelium.

Jin M, Li S, Moghrabi WN, Sun H, Travis GH.

Cell. 2005 Aug 12;122(3):449-59.


RPE65, visual cycle retinol isomerase, is not inherently 11-cis-specific: support for a carbocation mechanism of retinol isomerization.

Redmond TM, Poliakov E, Kuo S, Chander P, Gentleman S.

J Biol Chem. 2010 Jan 15;285(3):1919-27. doi: 10.1074/jbc.M109.027458. Epub 2009 Nov 17.


Crystal structure of native RPE65, the retinoid isomerase of the visual cycle.

Kiser PD, Golczak M, Lodowski DT, Chance MR, Palczewski K.

Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17325-30. doi: 10.1073/pnas.0906600106. Epub 2009 Oct 5.


Opsin activation of transduction in the rods of dark-reared Rpe65 knockout mice.

Fan J, Woodruff ML, Cilluffo MC, Crouch RK, Fain GL.

J Physiol. 2005 Oct 1;568(Pt 1):83-95. Epub 2005 Jul 1.


A human opsin-related gene that encodes a retinaldehyde-binding protein.

Shen D, Jiang M, Hao W, Tao L, Salazar M, Fong HK.

Biochemistry. 1994 Nov 8;33(44):13117-25.


Identification of a novel palmitylation site essential for membrane association and isomerohydrolase activity of RPE65.

Takahashi Y, Moiseyev G, Ablonczy Z, Chen Y, Crouch RK, Ma JX.

J Biol Chem. 2009 Jan 30;284(5):3211-8. doi: 10.1074/jbc.M807248200. Epub 2008 Dec 1.


Identification of the 11-cis-specific retinyl-ester synthase in retinal Müller cells as multifunctional O-acyltransferase (MFAT).

Kaylor JJ, Cook JD, Makshanoff J, Bischoff N, Yong J, Travis GH.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):7302-7. doi: 10.1073/pnas.1319142111. Epub 2014 May 5.


Cone outer segment morphology and cone function in the Rpe65-/- Nrl-/- mouse retina are amenable to retinoid replacement.

Kunchithapautham K, Coughlin B, Crouch RK, Rohrer B.

Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4858-64. doi: 10.1167/iovs.08-3008. Epub 2009 Apr 30.


Interaction of 11-cis-retinol dehydrogenase with the chromophore of retinal g protein-coupled receptor opsin.

Chen P, Lee TD, Fong HK.

J Biol Chem. 2001 Jun 15;276(24):21098-104. Epub 2001 Mar 27.


Release of 11-cis-retinal from cellular retinaldehyde-binding protein by acidic lipids.

Saari JC, Nawrot M, Stenkamp RE, Teller DC, Garwin GG.

Mol Vis. 2009;15:844-54. Epub 2009 Apr 23.


Mole quantity of RPE65 and its productivity in the generation of 11-cis-retinal from retinyl esters in the living mouse eye.

Lyubarsky AL, Savchenko AB, Morocco SB, Daniele LL, Redmond TM, Pugh EN Jr.

Biochemistry. 2005 Jul 26;44(29):9880-8.


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