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The acidic tail of the Cdc34 ubiquitin-conjugating enzyme functions in both binding to and catalysis with ubiquitin ligase SCFCdc4.

Kleiger G, Hao B, Mohl DA, Deshaies RJ.

J Biol Chem. 2009 Dec 25;284(52):36012-23. doi: 10.1074/jbc.M109.058529. Epub 2009 Oct 29.


Ubiquitin-conjugating enzyme Cdc34 and ubiquitin ligase Skp1-cullin-F-box ligase (SCF) interact through multiple conformations.

Sandoval D, Hill S, Ziemba A, Lewis S, Kuhlman B, Kleiger G.

J Biol Chem. 2015 Jan 9;290(2):1106-18. doi: 10.1074/jbc.M114.615559. Epub 2014 Nov 25.


SCF E3-mediated autoubiquitination negatively regulates activity of Cdc34 E2 but plays a nonessential role in the catalytic cycle in vitro and in vivo.

Scaglione KM, Bansal PK, Deffenbaugh AE, Kiss A, Moore JM, Korolev S, Cocklin R, Goebl M, Kitagawa K, Skowyra D.

Mol Cell Biol. 2007 Aug;27(16):5860-70. Epub 2007 Jun 11.


Rapid E2-E3 assembly and disassembly enable processive ubiquitylation of cullin-RING ubiquitin ligase substrates.

Kleiger G, Saha A, Lewis S, Kuhlman B, Deshaies RJ.

Cell. 2009 Nov 25;139(5):957-68. doi: 10.1016/j.cell.2009.10.030.


Multimodal mechanism of action for the Cdc34 acidic loop: a case study for why ubiquitin-conjugating enzymes have loops and tails.

Ziemba A, Hill S, Sandoval D, Webb K, Bennett EJ, Kleiger G.

J Biol Chem. 2013 Nov 29;288(48):34882-96. doi: 10.1074/jbc.M113.509190. Epub 2013 Oct 15.


Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34.

Seol JH, Feldman RM, Zachariae W, Shevchenko A, Correll CC, Lyapina S, Chi Y, Galova M, Claypool J, Sandmeyer S, Nasmyth K, Deshaies RJ, Shevchenko A, Deshaies RJ.

Genes Dev. 1999 Jun 15;13(12):1614-26.


Molecular basis for lysine specificity in the yeast ubiquitin-conjugating enzyme Cdc34.

Sadowski M, Suryadinata R, Lai X, Heierhorst J, Sarcevic B.

Mol Cell Biol. 2010 May;30(10):2316-29. doi: 10.1128/MCB.01094-09. Epub 2010 Mar 1.


The acidic tail domain of human Cdc34 is required for p27Kip1 ubiquitination and complementation of a cdc34 temperature sensitive yeast strain.

Block K, Appikonda S, Lin HR, Bloom J, Pagano M, Yew PR.

Cell Cycle. 2005 Oct;4(10):1421-7. Epub 2005 Oct 26.


The Cdc34/SCF ubiquitination complex mediates Saccharomyces cerevisiae cell wall integrity.

Varelas X, Stuart D, Ellison MJ, Ptak C.

Genetics. 2006 Dec;174(4):1825-39. Epub 2006 Oct 8.


Functional interaction of 13 yeast SCF complexes with a set of yeast E2 enzymes in vitro.

Kus BM, Caldon CE, Andorn-Broza R, Edwards AM.

Proteins. 2004 Feb 15;54(3):455-67.


Release of ubiquitin-charged Cdc34-S - Ub from the RING domain is essential for ubiquitination of the SCF(Cdc4)-bound substrate Sic1.

Deffenbaugh AE, Scaglione KM, Zhang L, Moore JM, Buranda T, Sklar LA, Skowyra D.

Cell. 2003 Sep 5;114(5):611-22.


Proximity-induced activation of human Cdc34 through heterologous dimerization.

Gazdoiu S, Yamoah K, Wu K, Escalante CR, Tappin I, Bermudez V, Aggarwal AK, Hurwitz J, Pan ZQ.

Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15053-8. Epub 2005 Oct 6.


Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box proteincomplexes that regulate cell division and methionine biosynthesis in yeast.

Patton EE, Willems AR, Sa D, Kuras L, Thomas D, Craig KL, Tyers M.

Genes Dev. 1998 Mar 1;12(5):692-705. Erratum in: Genes Dev 1998 Oct 1;12(19):3144.


The human Cdc34 carboxyl terminus contains a non-covalent ubiquitin binding activity that contributes to SCF-dependent ubiquitination.

Choi YS, Wu K, Jeong K, Lee D, Jeon YH, Choi BS, Pan ZQ, Ryu KS, Cheong C.

J Biol Chem. 2010 Jun 4;285(23):17754-62. doi: 10.1074/jbc.M109.090621. Epub 2010 Mar 30.


Cdc34: cycling on and off the SCF.

Pintard L, Peter M.

Nat Cell Biol. 2003 Oct;5(10):856-7. No abstract available.


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