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AF17 competes with AF9 for binding to Dot1a to up-regulate transcription of epithelial Na+ channel alpha.

Reisenauer MR, Anderson M, Huang L, Zhang Z, Zhou Q, Kone BC, Morris AP, Lesage GD, Dryer SE, Zhang W.

J Biol Chem. 2009 Dec 18;284(51):35659-69. doi: 10.1074/jbc.M109.038448.


AF17 facilitates Dot1a nuclear export and upregulates ENaC-mediated Na+ transport in renal collecting duct cells.

Wu H, Chen L, Zhou Q, Zhang W.

PLoS One. 2011;6(11):e27429. doi: 10.1371/journal.pone.0027429. Epub 2011 Nov 8.


Dot1a contains three nuclear localization signals and regulates the epithelial Na+ channel (ENaC) at multiple levels.

Reisenauer MR, Wang SW, Xia Y, Zhang W.

Am J Physiol Renal Physiol. 2010 Jul;299(1):F63-76. doi: 10.1152/ajprenal.00105.2010. Epub 2010 Apr 28.


Aldosterone-induced Sgk1 relieves Dot1a-Af9-mediated transcriptional repression of epithelial Na+ channel alpha.

Zhang W, Xia X, Reisenauer MR, Rieg T, Lang F, Kuhl D, Vallon V, Kone BC.

J Clin Invest. 2007 Mar;117(3):773-83.


Dot1a-AF9 complex mediates histone H3 Lys-79 hypermethylation and repression of ENaCalpha in an aldosterone-sensitive manner.

Zhang W, Xia X, Reisenauer MR, Hemenway CS, Kone BC.

J Biol Chem. 2006 Jun 30;281(26):18059-68. Epub 2006 Apr 24.


Regulation of αENaC transcription.

Chen L, Zhang X, Zhang W.

Vitam Horm. 2015;98:101-35. doi: 10.1016/bs.vh.2014.12.004. Epub 2015 Feb 14. Review.


Mineralocorticoid receptor antagonizes Dot1a-Af9 complex to increase αENaC transcription.

Zhang X, Zhou Q, Chen L, Berger S, Wu H, Xiao Z, Pearce D, Zhou X, Zhang W.

Am J Physiol Renal Physiol. 2013 Nov 15;305(10):F1436-44. doi: 10.1152/ajprenal.00202.2013. Epub 2013 Sep 11.


An Af9 cis-element directly targets Dot1a to mediate transcriptional repression of the αENaC gene.

Zhang W, Yu Z, Wu H, Chen L, Kong Q, Kone BC.

Am J Physiol Renal Physiol. 2013 Feb 15;304(4):F367-75. doi: 10.1152/ajprenal.00537.2011. Epub 2012 Nov 14.


Epigenetics of epithelial Na(+) channel-dependent sodium uptake and blood pressure regulation.

Zhang W.

World J Nephrol. 2015 Jul 6;4(3):363-6. doi: 10.5527/wjn.v4.i3.363. Review.


Sirtuin 1 functionally and physically interacts with disruptor of telomeric silencing-1 to regulate alpha-ENaC transcription in collecting duct.

Zhang D, Li S, Cruz P, Kone BC.

J Biol Chem. 2009 Jul 31;284(31):20917-26. doi: 10.1074/jbc.M109.020073. Epub 2009 Jun 2.


Spironolactone rescues Dot1a-Af9-mediated repression of endothelin-1 and improves kidney injury in streptozotocin-induced diabetic rats.

Zhou Q, Liu K, Wu H, Chen L, Pouranan V, Yuan M, Xiao Z, Peng W, Xiang A, Tang R, Zhang W.

PLoS One. 2012;7(10):e47360. doi: 10.1371/journal.pone.0047360. Epub 2012 Oct 15.


Epigenetics and the control of epithelial sodium channel expression in collecting duct.

Zhang D, Yu ZY, Cruz P, Kong Q, Li S, Kone BC.

Kidney Int. 2009 Feb;75(3):260-7. doi: 10.1038/ki.2008.475. Epub 2008 Sep 24. Review.


Aldosterone-sensitive repression of ENaCalpha transcription by a histone H3 lysine-79 methyltransferase.

Zhang W, Xia X, Jalal DI, Kuncewicz T, Xu W, Lesage GD, Kone BC.

Am J Physiol Cell Physiol. 2006 Mar;290(3):C936-46. Epub 2005 Oct 19.


Epigenetics and the control of the collecting duct epithelial sodium channel.

Kone BC.

Semin Nephrol. 2013 Jul;33(4):383-91. doi: 10.1016/j.semnephrol.2013.05.010. Review.


Sp1 trans-activates and is required for maximal aldosterone induction of the αENaC gene in collecting duct cells.

Yu Z, Kong Q, Kone BC.

Am J Physiol Renal Physiol. 2013 Sep 1;305(5):F653-62. doi: 10.1152/ajprenal.00177.2013. Epub 2013 Jun 26.


Regulation of sodium transport in mammalian collecting duct cells by aldosterone-induced kinase, SGK1: structure/function studies.

Náray-Fejes-Tóth A, Helms MN, Stokes JB, Fejes-Tóth G.

Mol Cell Endocrinol. 2004 Mar 31;217(1-2):197-202.


Af17 deficiency increases sodium excretion and decreases blood pressure.

Chen L, Wu H, Pochynyuk OM, Reisenauer MR, Zhang Z, Huang L, Zaika OL, Mamenko M, Zhang W, Zhou Q, Liu M, Xia Y, Zhang W.

J Am Soc Nephrol. 2011 Jun;22(6):1076-86. doi: 10.1681/ASN.2010121270. Epub 2011 May 5.


Epithelial sodium channel regulation by cell surface-associated serum- and glucocorticoid-regulated kinase 1.

Thomas SV, Kathpalia PP, Rajagopal M, Charlton C, Zhang J, Eaton DC, Helms MN, Pao AC.

J Biol Chem. 2011 Sep 16;286(37):32074-85. doi: 10.1074/jbc.M111.278283. Epub 2011 Jul 22.


New mechanisms for transcriptional repression of ENaC And iNOS.

Kone BC, Wenzhang Z, Zhiyuan Y.

Trans Am Clin Climatol Assoc. 2007;118:45-56.

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