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Items: 1 to 20 of 102

1.

Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation.

Sunami T, Byrne N, Diehl RE, Funabashi K, Hall DL, Ikuta M, Patel SB, Shipman JM, Smith RF, Takahashi I, Zugay-Murphy J, Iwasawa Y, Lumb KJ, Munshi SK, Sharma S.

J Biol Chem. 2010 Feb 12;285(7):4587-94. doi: 10.1074/jbc.M109.040667. Epub 2009 Oct 28.

2.

Hydrophobic motif phosphorylation is not required for activation loop phosphorylation of p70 ribosomal protein S6 kinase 1 (S6K1).

Keshwani MM, von Daake S, Newton AC, Harris TK, Taylor SS.

J Biol Chem. 2011 Jul 1;286(26):23552-8. doi: 10.1074/jbc.M111.258004. Epub 2011 May 11.

3.

Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease.

An WL, Cowburn RF, Li L, Braak H, Alafuzoff I, Iqbal K, Iqbal IG, Winblad B, Pei JJ.

Am J Pathol. 2003 Aug;163(2):591-607. Erratum in: Am J Pathol. 2003 Dec;163(6):2645.

4.

Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif.

Wang J, Zhong C, Wang F, Qu F, Ding J.

Biochem J. 2013 Aug 15;454(1):39-47. doi: 10.1042/BJ20121863.

PMID:
23731517
5.

Follicle-stimulating hormone activates p70 ribosomal protein S6 kinase by protein kinase A-mediated dephosphorylation of Thr 421/Ser 424 in primary Sertoli cells.

Lécureuil C, Tesseraud S, Kara E, Martinat N, Sow A, Fontaine I, Gauthier C, Reiter E, Guillou F, Crépieux P.

Mol Endocrinol. 2005 Jul;19(7):1812-20. Epub 2005 Mar 17.

PMID:
15774499
6.
7.

Activation of the p70 S6 kinase and phosphorylation of the 4E-BP1 repressor of mRNA translation by type I interferons.

Lekmine F, Uddin S, Sassano A, Parmar S, Brachmann SM, Majchrzak B, Sonenberg N, Hay N, Fish EN, Platanias LC.

J Biol Chem. 2003 Jul 25;278(30):27772-80. Epub 2003 May 20.

8.

Functional characterization of a maize ribosomal S6 protein kinase (ZmS6K), a plant ortholog of metazoan p70(S6K).

Reyes de la Cruz H, Aguilar R, Sánchez de Jiménez E.

Biochemistry. 2004 Jan 20;43(2):533-9.

PMID:
14717609
9.
10.

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro.

Alessi DR, Kozlowski MT, Weng QP, Morrice N, Avruch J.

Curr Biol. 1998 Jan 15;8(2):69-81.

12.

Low-scale phosphoproteome analyses identify the mTOR effector p70 S6 kinase 1 as a specific biomarker of the dual-HER1/HER2 tyrosine kinase inhibitor lapatinib (Tykerb) in human breast carcinoma cells.

Vazquez-Martin A, Oliveras-Ferraros C, Colomer R, Brunet J, Menendez JA.

Ann Oncol. 2008 Jun;19(6):1097-109. doi: 10.1093/annonc/mdm589. Epub 2008 Feb 17.

PMID:
18283037
13.

Crystal structures of the N-terminal kinase domain of human RSK1 bound to three different ligands: Implications for the design of RSK1 specific inhibitors.

Ikuta M, Kornienko M, Byrne N, Reid JC, Mizuarai S, Kotani H, Munshi SK.

Protein Sci. 2007 Dec;16(12):2626-35. Epub 2007 Oct 26.

14.

p70 Ribosomal S6 kinase is required for airway smooth muscle cell size enlargement but not increased contractile protein expression.

Deng H, Hershenson MB, Lei J, Bitar KN, Fingar DC, Solway J, Bentley JK.

Am J Respir Cell Mol Biol. 2010 Jun;42(6):744-52. doi: 10.1165/rcmb.2009-0037OC. Epub 2009 Jul 31.

15.

Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain.

Lee CC, Jia Y, Li N, Sun X, Ng K, Ambing E, Gao MY, Hua S, Chen C, Kim S, Michellys PY, Lesley SA, Harris JL, Spraggon G.

Biochem J. 2010 Sep 15;430(3):425-37. doi: 10.1042/BJ20100609.

PMID:
20632993
16.

ET-18-OCH3 inhibits the phosphorylation and activation of p70 S6 kinase in MCF-7 cells.

Arthur G, Samadder P, Bittman R.

Anticancer Res. 2005 Jan-Feb;25(1A):95-100.

17.
18.

Two widely used RSK inhibitors, BI-D1870 and SL0101, alter mTORC1 signaling in a RSK-independent manner.

Roffé M, Lupinacci FC, Soares LC, Hajj GN, Martins VR.

Cell Signal. 2015 Aug;27(8):1630-42. doi: 10.1016/j.cellsig.2015.04.004. Epub 2015 Apr 16.

PMID:
25889895
19.

Interferon-gamma engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein.

Lekmine F, Sassano A, Uddin S, Smith J, Majchrzak B, Brachmann SM, Hay N, Fish EN, Platanias LC.

Exp Cell Res. 2004 Apr 15;295(1):173-82.

PMID:
15051500

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