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Items: 1 to 20 of 101


Synphilin-1 exhibits trophic and protective effects against Rotenone toxicity.

Li X, Liu Z, Tamashiro K, Shi B, Rudnicki DD, Ross CA, Moran TH, Smith WW.

Neuroscience. 2010 Jan 20;165(2):455-62. doi: 10.1016/j.neuroscience.2009.10.042.


Caspase-3-derived C-terminal product of synphilin-1 displays antiapoptotic function via modulation of the p53-dependent cell death pathway.

Giaime E, Sunyach C, Herrant M, Grosso S, Auberger P, McLean PJ, Checler F, da Costa CA.

J Biol Chem. 2006 Apr 28;281(17):11515-22. Epub 2006 Feb 22.


Ellagic acid mitigates SNO-PDI induced aggregation of Parkinsonian biomarkers.

Kabiraj P, Marin JE, Varela-Ramirez A, Zubia E, Narayan M.

ACS Chem Neurosci. 2014 Dec 17;5(12):1209-20. doi: 10.1021/cn500214k. Epub 2014 Oct 8.


Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model.

Smith WW, Liu Z, Liang Y, Masuda N, Swing DA, Jenkins NA, Copeland NG, Troncoso JC, Pletnikov M, Dawson TM, Martin LJ, Moran TH, Lee MK, Borchelt DR, Ross CA.

Hum Mol Genet. 2010 Jun 1;19(11):2087-98. doi: 10.1093/hmg/ddq086. Epub 2010 Feb 25.


Protective effect of histamine H2 receptor antagonist ranitidine against rotenone-induced apoptosis.

Park HJ, Kim HJ, Park HK, Chung JH.

Neurotoxicology. 2009 Nov;30(6):1114-9. doi: 10.1016/j.neuro.2009.08.005. Epub 2009 Aug 31.


An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage.

Sherer TB, Betarbet R, Stout AK, Lund S, Baptista M, Panov AV, Cookson MR, Greenamyre JT.

J Neurosci. 2002 Aug 15;22(16):7006-15.


Tranexamic acid protects against rotenone-induced apoptosis in human neuroblastoma SH-SY5Y cells.

Kim HJ, Park HJ, Park HK, Chung JH.

Toxicology. 2009 Aug 3;262(2):171-4. doi: 10.1016/j.tox.2009.06.004. Epub 2009 Jun 16.


Nitrosative stress mediated misfolded protein aggregation mitigated by Na-D-β-hydroxybutyrate intervention.

Kabiraj P, Pal R, Varela-Ramirez A, Miranda M, Narayan M.

Biochem Biophys Res Commun. 2012 Sep 28;426(3):438-44. doi: 10.1016/j.bbrc.2012.08.121. Epub 2012 Sep 4.


Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective.

Tanaka M, Kim YM, Lee G, Junn E, Iwatsubo T, Mouradian MM.

J Biol Chem. 2004 Feb 6;279(6):4625-31. Epub 2003 Nov 19.


D2/D3 receptor agonist ropinirole protects dopaminergic cell line against rotenone-induced apoptosis through inhibition of caspase- and JNK-dependent pathways.

Chen S, Zhang X, Yang D, Du Y, Li L, Li X, Ming M, Le W.

FEBS Lett. 2008 Mar 5;582(5):603-10. doi: 10.1016/j.febslet.2008.01.028. Epub 2008 Jan 31.


Poly(ADP-ribose) polymerase (PARP)-1-independent apoptosis-inducing factor (AIF) release and cell death are induced by eleostearic acid and blocked by alpha-tocopherol and MEK inhibition.

Kondo K, Obitsu S, Ohta S, Matsunami K, Otsuka H, Teshima R.

J Biol Chem. 2010 Apr 23;285(17):13079-91. doi: 10.1074/jbc.M109.044206. Epub 2010 Feb 22.


Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease.

Liani E, Eyal A, Avraham E, Shemer R, Szargel R, Berg D, Bornemann A, Riess O, Ross CA, Rott R, Engelender S.

Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5500-5. Epub 2004 Apr 2.


Valproic acid-mediated Hsp70 induction and anti-apoptotic neuroprotection in SH-SY5Y cells.

Pan T, Li X, Xie W, Jankovic J, Le W.

FEBS Lett. 2005 Dec 19;579(30):6716-20. Epub 2005 Nov 21.


Synphilin-1 degradation by the ubiquitin-proteasome pathway and effects on cell survival.

Lee G, Junn E, Tanaka M, Kim YM, Mouradian MM.

J Neurochem. 2002 Oct;83(2):346-52.


Aggregate formation and toxicity by wild-type and R621C synphilin-1 in the nigrostriatal system of mice using adenoviral vectors.

Krenz A, Falkenburger BH, Gerhardt E, Drinkut A, Schulz JB.

J Neurochem. 2009 Jan;108(1):139-46. doi: 10.1111/j.1471-4159.2008.05755.x.


Synphilin isoforms and the search for a cellular model of lewy body formation in Parkinson's disease.

Eyal A, Engelender S.

Cell Cycle. 2006 Sep;5(18):2082-6. Epub 2006 Sep 15. Review.


Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease.

Marx FP, Holzmann C, Strauss KM, Li L, Eberhardt O, Gerhardt E, Cookson MR, Hernandez D, Farrer MJ, Kachergus J, Engelender S, Ross CA, Berger K, Schöls L, Schulz JB, Riess O, Krüger R.

Hum Mol Genet. 2003 Jun 1;12(11):1223-31.


Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.

Hans CP, Zerfaoui M, Naura AS, Catling A, Boulares AH.

Cardiovasc Res. 2008 Jun 1;78(3):429-39. doi: 10.1093/cvr/cvn018. Epub 2008 Jan 31.


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