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Items: 1 to 20 of 111

1.

Proteomic remodelling of mitochondrial oxidative pathways in pressure overload-induced heart failure.

Bugger H, Schwarzer M, Chen D, Schrepper A, Amorim PA, Schoepe M, Nguyen TD, Mohr FW, Khalimonchuk O, Weimer BC, Doenst T.

Cardiovasc Res. 2010 Jan 15;85(2):376-84. doi: 10.1093/cvr/cvp344. Epub 2009 Oct 19.

PMID:
19843514
2.

Induction of heart failure by minimally invasive aortic constriction in mice: reduced peroxisome proliferator-activated receptor γ coactivator levels and mitochondrial dysfunction.

Faerber G, Barreto-Perreia F, Schoepe M, Gilsbach R, Schrepper A, Schwarzer M, Mohr FW, Hein L, Doenst T.

J Thorac Cardiovasc Surg. 2011 Feb;141(2):492-500, 500.e1. doi: 10.1016/j.jtcvs.2010.03.029. Epub 2010 May 5.

3.

Myocardial infarction in rats causes partial impairment in insulin response associated with reduced fatty acid oxidation and mitochondrial gene expression.

Amorim PA, Nguyen TD, Shingu Y, Schwarzer M, Mohr FW, Schrepper A, Doenst T.

J Thorac Cardiovasc Surg. 2010 Nov;140(5):1160-7. doi: 10.1016/j.jtcvs.2010.08.003. Epub 2010 Sep 17.

4.

Decreased rates of substrate oxidation ex vivo predict the onset of heart failure and contractile dysfunction in rats with pressure overload.

Doenst T, Pytel G, Schrepper A, Amorim P, Färber G, Shingu Y, Mohr FW, Schwarzer M.

Cardiovasc Res. 2010 Jun 1;86(3):461-70. doi: 10.1093/cvr/cvp414. Epub 2009 Dec 24.

PMID:
20035032
5.

PGC-1β deficiency accelerates the transition to heart failure in pressure overload hypertrophy.

Riehle C, Wende AR, Zaha VG, Pires KM, Wayment B, Olsen C, Bugger H, Buchanan J, Wang X, Moreira AB, Doenst T, Medina-Gomez G, Litwin SE, Lelliott CJ, Vidal-Puig A, Abel ED.

Circ Res. 2011 Sep 16;109(7):783-93. doi: 10.1161/CIRCRESAHA.111.243964. Epub 2011 Jul 28.

6.

Regulation of fatty acid metabolism by mTOR in adult murine hearts occurs independently of changes in PGC-1α.

Zhu Y, Soto J, Anderson B, Riehle C, Zhang YC, Wende AR, Jones D, McClain DA, Abel ED.

Am J Physiol Heart Circ Physiol. 2013 Jul 1;305(1):H41-51. doi: 10.1152/ajpheart.00877.2012. Epub 2013 Apr 26.

7.

Dietary fat supply to failing hearts determines dynamic lipid signaling for nuclear receptor activation and oxidation of stored triglyceride.

Lahey R, Wang X, Carley AN, Lewandowski ED.

Circulation. 2014 Nov 11;130(20):1790-9. doi: 10.1161/CIRCULATIONAHA.114.011687. Epub 2014 Sep 29.

8.

Infarct-remodelled hearts with limited oxidative capacity boost fatty acid oxidation after conditioning against ischaemia/reperfusion injury.

Lou PH, Zhang L, Lucchinetti E, Heck M, Affolter A, Gandhi M, Kienesberger PC, Hersberger M, Clanachan AS, Zaugg M.

Cardiovasc Res. 2013 Feb 1;97(2):251-61. doi: 10.1093/cvr/cvs323. Epub 2012 Oct 24.

PMID:
23097573
9.

Metabolic gene remodeling and mitochondrial dysfunction in failing right ventricular hypertrophy secondary to pulmonary arterial hypertension.

Gomez-Arroyo J, Mizuno S, Szczepanek K, Van Tassell B, Natarajan R, dos Remedios CG, Drake JI, Farkas L, Kraskauskas D, Wijesinghe DS, Chalfant CE, Bigbee J, Abbate A, Lesnefsky EJ, Bogaard HJ, Voelkel NF.

Circ Heart Fail. 2013 Jan;6(1):136-44. doi: 10.1161/CIRCHEARTFAILURE.111.966127. Epub 2012 Nov 14.

10.

Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart.

Boudina S, Bugger H, Sena S, O'Neill BT, Zaha VG, Ilkun O, Wright JJ, Mazumder PK, Palfreyman E, Tidwell TJ, Theobald H, Khalimonchuk O, Wayment B, Sheng X, Rodnick KJ, Centini R, Chen D, Litwin SE, Weimer BE, Abel ED.

Circulation. 2009 Mar 10;119(9):1272-83. doi: 10.1161/CIRCULATIONAHA.108.792101. Epub 2009 Feb 23.

11.

Freshly isolated mitochondria from failing human hearts exhibit preserved respiratory function.

Cordero-Reyes AM, Gupte AA, Youker KA, Loebe M, Hsueh WA, Torre-Amione G, Taegtmeyer H, Hamilton DJ.

J Mol Cell Cardiol. 2014 Mar;68:98-105. doi: 10.1016/j.yjmcc.2013.12.029. Epub 2014 Jan 9.

12.

Proteomic analysis of mitochondria reveals a metabolic switch from fatty acid oxidation to glycolysis in the failing heart.

Wang J, Bai L, Li J, Sun C, Zhao J, Cui C, Han K, Liu Y, Zhuo X, Wang T, Liu P, Fan F, Guan Y, Ma A.

Sci China C Life Sci. 2009 Nov;52(11):1003-10. doi: 10.1007/s11427-009-0140-2. Epub 2009 Nov 24.

PMID:
19937197
13.

The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis.

Lehman JJ, Boudina S, Banke NH, Sambandam N, Han X, Young DM, Leone TC, Gross RW, Lewandowski ED, Abel ED, Kelly DP.

Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H185-96. doi: 10.1152/ajpheart.00081.2008. Epub 2008 May 16.

14.

Impaired myocardial fatty acid oxidation and reduced protein expression of retinoid X receptor-alpha in pacing-induced heart failure.

Osorio JC, Stanley WC, Linke A, Castellari M, Diep QN, Panchal AR, Hintze TH, Lopaschuk GD, Recchia FA.

Circulation. 2002 Jul 30;106(5):606-12.

15.

The metabolic modulators, Etomoxir and NVP-LAB121, fail to reverse pressure overload induced heart failure in vivo.

Schwarzer M, Faerber G, Rueckauer T, Blum D, Pytel G, Mohr FW, Doenst T.

Basic Res Cardiol. 2009 Sep;104(5):547-57. doi: 10.1007/s00395-009-0015-5. Epub 2009 Mar 14.

PMID:
19294446
16.

Oxidative post-translational modifications develop LONP1 dysfunction in pressure overload heart failure.

Hoshino A, Okawa Y, Ariyoshi M, Kaimoto S, Uchihashi M, Fukai K, Iwai-Kanai E, Matoba S.

Circ Heart Fail. 2014 May;7(3):500-9. doi: 10.1161/CIRCHEARTFAILURE.113.001062. Epub 2014 Apr 16.

17.

Cardiac mitochondrial proteome dynamics with heavy water reveals stable rate of mitochondrial protein synthesis in heart failure despite decline in mitochondrial oxidative capacity.

Shekar KC, Li L, Dabkowski ER, Xu W, Ribeiro RF Jr, Hecker PA, Recchia FA, Sadygov RG, Willard B, Kasumov T, Stanley WC.

J Mol Cell Cardiol. 2014 Oct;75:88-97. doi: 10.1016/j.yjmcc.2014.06.014. Epub 2014 Jul 1.

18.

Defective DNA replication impairs mitochondrial biogenesis in human failing hearts.

Karamanlidis G, Nascimben L, Couper GS, Shekar PS, del Monte F, Tian R.

Circ Res. 2010 May 14;106(9):1541-8. doi: 10.1161/CIRCRESAHA.109.212753. Epub 2010 Mar 25.

19.

In obese Zucker rats, lipids accumulate in the heart despite normal mitochondrial content, morphology and long-chain fatty acid oxidation.

Holloway GP, Snook LA, Harris RJ, Glatz JF, Luiken JJ, Bonen A.

J Physiol. 2011 Jan 1;589(Pt 1):169-80. doi: 10.1113/jphysiol.2010.198663. Epub 2010 Nov 1.

20.

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