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Items: 1 to 20 of 115

1.

Osteogenic oxysterol, 20(S)-hydroxycholesterol, induces notch target gene expression in bone marrow stromal cells.

Kim WK, Meliton V, Tetradis S, Weinmaster G, Hahn TJ, Carlson M, Nelson SF, Parhami F.

J Bone Miner Res. 2010 Apr;25(4):782-95. doi: 10.1359/jbmr.091024.

2.
3.

Negative regulation of Hedgehog signaling by liver X receptors.

Kim WK, Meliton V, Park KW, Hong C, Tontonoz P, Niewiadomski P, Waschek JA, Tetradis S, Parhami F.

Mol Endocrinol. 2009 Oct;23(10):1532-43. doi: 10.1210/me.2008-0453. Epub 2009 Jul 16.

4.

Oxysterol-induced osteogenic differentiation of marrow stromal cells is regulated by Dkk-1 inhibitable and PI3-kinase mediated signaling.

Amantea CM, Kim WK, Meliton V, Tetradis S, Parhami F.

J Cell Biochem. 2008 Oct 1;105(2):424-36. doi: 10.1002/jcb.21840.

5.

Novel oxysterols have pro-osteogenic and anti-adipogenic effects in vitro and induce spinal fusion in vivo.

Johnson JS, Meliton V, Kim WK, Lee KB, Wang JC, Nguyen K, Yoo D, Jung ME, Atti E, Tetradis S, Pereira RC, Magyar C, Nargizyan T, Hahn TJ, Farouz F, Thies S, Parhami F.

J Cell Biochem. 2011 Jun;112(6):1673-84. doi: 10.1002/jcb.23082.

6.

Repression of chondrogenesis through binding of notch signaling proteins HES-1 and HEY-1 to N-box domains in the COL2A1 enhancer site.

Grogan SP, Olee T, Hiraoka K, Lotz MK.

Arthritis Rheum. 2008 Sep;58(9):2754-63. doi: 10.1002/art.23730.

7.

Mitochondrial function contributes to oxysterol-induced osteogenic differentiation in mouse embryonic stem cells.

Kwon IK, Lee SC, Hwang YS, Heo JS.

Biochim Biophys Acta. 2015 Mar;1853(3):561-72. doi: 10.1016/j.bbamcr.2014.12.011. Epub 2014 Dec 16.

8.

Hedgehog signaling and osteogenic differentiation in multipotent bone marrow stromal cells are inhibited by oxidative stress.

Kim WK, Meliton V, Bourquard N, Hahn TJ, Parhami F.

J Cell Biochem. 2010 Dec 1;111(5):1199-209. doi: 10.1002/jcb.22846.

PMID:
20717924
9.

A novel osteogenic oxysterol compound for therapeutic development to promote bone growth: activation of hedgehog signaling and osteogenesis through smoothened binding.

Montgomery SR, Nargizyan T, Meliton V, Nachtergaele S, Rohatgi R, Stappenbeck F, Jung ME, Johnson JS, Aghdasi B, Tian H, Weintraub G, Inoue H, Atti E, Tetradis S, Pereira RC, Hokugo A, Alobaidaan R, Tan Y, Hahn TJ, Wang JC, Parhami F.

J Bone Miner Res. 2014 Aug;29(8):1872-85. doi: 10.1002/jbmr.2213.

10.

Notch signaling proteins HES-1 and Hey-1 bind to insulin degrading enzyme (IDE) proximal promoter and repress its transcription and activity: implications for cellular Aβ metabolism.

Leal MC, Surace EI, Holgado MP, Ferrari CC, Tarelli R, Pitossi F, Wisniewski T, Castaño EM, Morelli L.

Biochim Biophys Acta. 2012 Feb;1823(2):227-35. doi: 10.1016/j.bbamcr.2011.09.014. Epub 2011 Oct 19.

11.

In vitro osteoinductive effects of hydroxycholesterol on human adipose-derived stem cells are mediated through the hedgehog signaling pathway.

Yalom A, Hokugo A, Sorice S, Li A, Segovia Aguilar LA, Zuk P, Jarrahy R.

Plast Reconstr Surg. 2014 Nov;134(5):960-8. doi: 10.1097/PRS.0000000000000601.

PMID:
25347631
12.

Regulation of osteoclast development by Notch signaling directed to osteoclast precursors and through stromal cells.

Yamada T, Yamazaki H, Yamane T, Yoshino M, Okuyama H, Tsuneto M, Kurino T, Hayashi S, Sakano S.

Blood. 2003 Mar 15;101(6):2227-34. Epub 2002 Oct 31.

13.

Osteogenic oxysterols inhibit the adverse effects of oxidative stress on osteogenic differentiation of marrow stromal cells.

Shouhed D, Kha HT, Richardson JA, Amantea CM, Hahn TJ, Parhami F.

J Cell Biochem. 2005 Aug 15;95(6):1276-83.

PMID:
15880703
14.

Silk proteins stimulate osteoblast differentiation by suppressing the Notch signaling pathway in mesenchymal stem cells.

Jung SR, Song NJ, Yang DK, Cho YJ, Kim BJ, Hong JW, Yun UJ, Jo DG, Lee YM, Choi SY, Park KW.

Nutr Res. 2013 Feb;33(2):162-70. doi: 10.1016/j.nutres.2012.11.006. Epub 2012 Dec 20.

PMID:
23399667
15.

The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling: a potential mechanism of therapeutic resistance.

Schreck KC, Taylor P, Marchionni L, Gopalakrishnan V, Bar EE, Gaiano N, Eberhart CG.

Clin Cancer Res. 2010 Dec 15;16(24):6060-70. doi: 10.1158/1078-0432.CCR-10-1624.

16.

Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development.

Tateya T, Imayoshi I, Tateya I, Ito J, Kageyama R.

Dev Biol. 2011 Apr 15;352(2):329-40. doi: 10.1016/j.ydbio.2011.01.038. Epub 2011 Feb 16.

17.

Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells.

Dwyer JR, Sever N, Carlson M, Nelson SF, Beachy PA, Parhami F.

J Biol Chem. 2007 Mar 23;282(12):8959-68. Epub 2007 Jan 2.

18.

Active sonic hedgehog signaling between androgen independent human prostate cancer cells and normal/benign but not cancer-associated prostate stromal cells.

Shigemura K, Huang WC, Li X, Zhau HE, Zhu G, Gotoh A, Fujisawa M, Xie J, Marshall FF, Chung LW.

Prostate. 2011 Dec;71(16):1711-22. doi: 10.1002/pros.21388. Epub 2011 Apr 25.

19.

ATF2 maintains a subset of neural progenitors through CBF1/Notch independent Hes-1 expression and synergistically activates the expression of Hes-1 in Notch-dependent neural progenitors.

Sanalkumar R, Indulekha CL, Divya TS, Divya MS, Anto RJ, Vinod B, Vidyanand S, Jagatha B, Venugopal S, James J.

J Neurochem. 2010 May;113(4):807-18. doi: 10.1111/j.1471-4159.2010.06574.x. Epub 2010 Jan 8.

20.

In vitro study of a novel oxysterol for osteogenic differentiation on rabbit bone marrow stromal cells.

Hokugo A, Sorice S, Yalom A, Lee JC, Li A, Zuk P, Jarrahy R.

Plast Reconstr Surg. 2013 Jul;132(1):70e-80e. doi: 10.1097/PRS.0b013e318290f460.

PMID:
23806956

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