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Mapping of protein phosphatase-6 association with its SAPS domain regulatory subunit using a model of helical repeats.

Guergnon J, Derewenda U, Edelson JR, Brautigan DL.

BMC Biochem. 2009 Oct 16;10:24. doi: 10.1186/1471-2091-10-24.


Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon.

Stefansson B, Brautigan DL.

J Biol Chem. 2006 Aug 11;281(32):22624-34. Epub 2006 Jun 12.


Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains.

Stefansson B, Ohama T, Daugherty AE, Brautigan DL.

Biochemistry. 2008 Feb 5;47(5):1442-51. doi: 10.1021/bi7022877. Epub 2008 Jan 11.


Human protein phosphatase PP6 regulatory subunits provide Sit4-dependent and rapamycin-sensitive sap function in Saccharomyces cerevisiae.

Morales-Johansson H, Puria R, Brautigan DL, Cardenas ME.

PLoS One. 2009 Jul 21;4(7):e6331. doi: 10.1371/journal.pone.0006331.


Overlapping binding sites in protein phosphatase 2A for association with regulatory A and alpha-4 (mTap42) subunits.

Prickett TD, Brautigan DL.

J Biol Chem. 2004 Sep 10;279(37):38912-20. Epub 2004 Jul 13.


Protein phosphatase PP6 N terminal domain restricts G1 to S phase progression in human cancer cells.

Stefansson B, Brautigan DL.

Cell Cycle. 2007 Jun 1;6(11):1386-92. Epub 2007 Jun 11.


Parallel purification of three catalytic subunits of the protein serine/threonine phosphatase 2A family (PP2A(C), PP4(C), and PP6(C)) and analysis of the interaction of PP2A(C) with alpha4 protein.

Kloeker S, Reed R, McConnell JL, Chang D, Tran K, Westphal RS, Law BK, Colbran RJ, Kamoun M, Campbell KS, Wadzinski BE.

Protein Expr Purif. 2003 Sep;31(1):19-33.


Activation of DNA-PK by ionizing radiation is mediated by protein phosphatase 6.

Mi J, Dziegielewski J, Bolesta E, Brautigan DL, Larner JM.

PLoS One. 2009;4(2):e4395. doi: 10.1371/journal.pone.0004395. Epub 2009 Feb 9.


The SAP, a new family of proteins, associate and function positively with the SIT4 phosphatase.

Luke MM, Della Seta F, Di Como CJ, Sugimoto H, Kobayashi R, Arndt KT.

Mol Cell Biol. 1996 Jun;16(6):2744-55.


Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX.

Douglas P, Zhong J, Ye R, Moorhead GB, Xu X, Lees-Miller SP.

Mol Cell Biol. 2010 Mar;30(6):1368-81. doi: 10.1128/MCB.00741-09. Epub 2010 Jan 11.


The three Type 2A protein phosphatases, PP2Ac, PP4c and PP6c, are differentially regulated by Alpha4.

LeNoue-Newton ML, Wadzinski BE, Spiller BW.

Biochem Biophys Res Commun. 2016 Jun 17;475(1):64-9. doi: 10.1016/j.bbrc.2016.05.036. Epub 2016 May 8.


Interaction with Tap42 is required for the essential function of Sit4 and type 2A phosphatases.

Wang H, Wang X, Jiang Y.

Mol Biol Cell. 2003 Nov;14(11):4342-51. Epub 2003 Jul 25.


Domains necessary for Galpha12 binding and stimulation of protein phosphatase-2A (PP2A): Is Galpha12 a novel regulatory subunit of PP2A?

Zhu D, Tate RI, Ruediger R, Meigs TE, Denker BM.

Mol Pharmacol. 2007 May;71(5):1268-76. Epub 2007 Feb 15.


The structure of Tap42/alpha4 reveals a tetratricopeptide repeat-like fold and provides insights into PP2A regulation.

Yang J, Roe SM, Prickett TD, Brautigan DL, Barford D.

Biochemistry. 2007 Jul 31;46(30):8807-15. Epub 2007 Jul 6.


The alpha4 regulatory subunit exerts opposing allosteric effects on protein phosphatases PP6 and PP2A.

Prickett TD, Brautigan DL.

J Biol Chem. 2006 Oct 13;281(41):30503-11. Epub 2006 Aug 8.


Protein phosphatase 2A holoenzyme assembly: identification of contacts between B-family regulatory and scaffolding A subunits.

Strack S, Ruediger R, Walter G, Dagda RK, Barwacz CA, Cribbs JT.

J Biol Chem. 2002 Jun 7;277(23):20750-5. Epub 2002 Apr 2.


Functions of protein phosphatase-6 in NF-κB signaling and in lymphocytes.

Ziembik MA, Bender TP, Larner JM, Brautigan DL.

Biochem Soc Trans. 2017 Jun 15;45(3):693-701. doi: 10.1042/BST20160169. Review.


HEAT repeat 1 motif is required for B56γ-containing protein phosphatase 2A (B56γ-PP2A) holoenzyme assembly and tumor-suppressive function.

Nobumori Y, Shouse GP, Fan L, Liu X.

J Biol Chem. 2012 Mar 30;287(14):11030-6. doi: 10.1074/jbc.M111.334094. Epub 2012 Feb 7.

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