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Items: 1 to 20 of 123


Identification of a physiological E2 module for the human anaphase-promoting complex.

Williamson A, Wickliffe KE, Mellone BG, Song L, Karpen GH, Rape M.

Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18213-8. doi: 10.1073/pnas.0907887106. Epub 2009 Oct 12.


UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complex.

Wu T, Merbl Y, Huo Y, Gallop JL, Tzur A, Kirschner MW.

Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1355-60. doi: 10.1073/pnas.0912802107. Epub 2010 Jan 6.


UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit.

Garnett MJ, Mansfeld J, Godwin C, Matsusaka T, Wu J, Russell P, Pines J, Venkitaraman AR.

Nat Cell Biol. 2009 Nov;11(11):1363-9. doi: 10.1038/ncb1983. Epub 2009 Oct 11.


Efficient APC/C substrate degradation in cells undergoing mitotic exit depends on K11 ubiquitin linkages.

Min M, Mevissen TE, De Luca M, Komander D, Lindon C.

Mol Biol Cell. 2015 Dec 1;26(24):4325-32. doi: 10.1091/mbc.E15-02-0102. Epub 2015 Oct 7.


Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry.

Rape M, Kirschner MW.

Nature. 2004 Dec 2;432(7017):588-95. Epub 2004 Nov 21.


The E2-C vihar is required for the correct spatiotemporal proteolysis of cyclin B and itself undergoes cyclical degradation.

Máthé E, Kraft C, Giet R, Deák P, Peters JM, Glover DM.

Curr Biol. 2004 Oct 5;14(19):1723-33.


Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex.

Jin L, Williamson A, Banerjee S, Philipp I, Rape M.

Cell. 2008 May 16;133(4):653-65. doi: 10.1016/j.cell.2008.04.012.


Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex.

Wang W, Kirschner MW.

Nat Cell Biol. 2013 Jul;15(7):797-806. doi: 10.1038/ncb2755. Epub 2013 May 26.


Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex.

Herzog F, Primorac I, Dube P, Lenart P, Sander B, Mechtler K, Stark H, Peters JM.

Science. 2009 Mar 13;323(5920):1477-81. doi: 10.1126/science.1163300.


An E2 enzyme Ubc11 is required for ubiquitination of Slp1/Cdc20 and spindle checkpoint silencing in fission yeast.

Horikoshi Y, Habu T, Matsumoto T.

Cell Cycle. 2013 Mar 15;12(6):961-71. doi: 10.4161/cc.23946. Epub 2013 Feb 26.


Atomic structure of the APC/C and its mechanism of protein ubiquitination.

Chang L, Zhang Z, Yang J, McLaughlin SH, Barford D.

Nature. 2015 Jun 25;522(7557):450-454. doi: 10.1038/nature14471. Epub 2015 Jun 15.


Processive ubiquitin chain formation by the anaphase-promoting complex.

Meyer HJ, Rape M.

Semin Cell Dev Biol. 2011 Aug;22(6):544-50. doi: 10.1016/j.semcdb.2011.03.009. Epub 2011 Apr 6. Review.


APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1.

Dimova NV, Hathaway NA, Lee BH, Kirkpatrick DS, Berkowitz ML, Gygi SP, Finley D, King RW.

Nat Cell Biol. 2012 Jan 29;14(2):168-76. doi: 10.1038/ncb2425.


RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex.

Brown NG, VanderLinden R, Watson ER, Qiao R, Grace CR, Yamaguchi M, Weissmann F, Frye JJ, Dube P, Ei Cho S, Actis ML, Rodrigues P, Fujii N, Peters JM, Stark H, Schulman BA.

Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5272-9. doi: 10.1073/pnas.1504161112. Epub 2015 Mar 30.


Control of APC/C-dependent ubiquitin chain elongation by reversible phosphorylation.

Craney A, Kelly A, Jia L, Fedrigo I, Yu H, Rape M.

Proc Natl Acad Sci U S A. 2016 Feb 9;113(6):1540-5. doi: 10.1073/pnas.1522423113. Epub 2016 Jan 25.


WD40 domain of Apc1 is critical for the coactivator-induced allosteric transition that stimulates APC/C catalytic activity.

Li Q, Chang L, Aibara S, Yang J, Zhang Z, Barford D.

Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):10547-52. doi: 10.1073/pnas.1607147113. Epub 2016 Sep 6.


Spindle assembly checkpoint protein Cdc20 transcriptionally activates expression of ubiquitin carrier protein UbcH10.

Nath S, Banerjee T, Sen D, Das T, Roychoudhury S.

J Biol Chem. 2011 May 6;286(18):15666-77. doi: 10.1074/jbc.M110.160671. Epub 2011 Mar 15.


Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation.

Yamaguchi M, VanderLinden R, Weissmann F, Qiao R, Dube P, Brown NG, Haselbach D, Zhang W, Sidhu SS, Peters JM, Stark H, Schulman BA.

Mol Cell. 2016 Aug 18;63(4):593-607. doi: 10.1016/j.molcel.2016.07.003. Epub 2016 Aug 10.


The unique N terminus of the UbcH10 E2 enzyme controls the threshold for APC activation and enhances checkpoint regulation of the APC.

Summers MK, Pan B, Mukhyala K, Jackson PK.

Mol Cell. 2008 Aug 22;31(4):544-56. doi: 10.1016/j.molcel.2008.07.014.


Mitotic regulation of the anaphase-promoting complex.

Baker DJ, Dawlaty MM, Galardy P, van Deursen JM.

Cell Mol Life Sci. 2007 Mar;64(5):589-600. Review.


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