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Altered thymic selection by overexpressing cellular FLICE inhibitory protein in T cells causes lupus-like syndrome in a BALB/c but not C57BL/6 strain.

Qiao G, Li Z, Minto AW, Shia J, Yang L, Bao L, Tschopp J, Gao JX, Wang J, Quigg RJ, Zhang J.

Cell Death Differ. 2010 Mar;17(3):522-33. doi: 10.1038/cdd.2009.143. Epub 2009 Oct 9.


Apigenin, a non-mutagenic dietary flavonoid, suppresses lupus by inhibiting autoantigen presentation for expansion of autoreactive Th1 and Th17 cells.

Kang HK, Ecklund D, Liu M, Datta SK.

Arthritis Res Ther. 2009;11(2):R59. doi: 10.1186/ar2682. Epub 2009 Apr 30.


Cellular FLIP long form augments caspase activity and death of T cells through heterodimerization with and activation of caspase-8.

Dohrman A, Russell JQ, Cuenin S, Fortner K, Tschopp J, Budd RC.

J Immunol. 2005 Jul 1;175(1):311-8.


Cellular FLIP (long isoform) overexpression in T cells drives Th2 effector responses and promotes immunoregulation in experimental autoimmune encephalomyelitis.

Tseveleki V, Bauer J, Taoufik E, Ruan C, Leondiadis L, Haralambous S, Lassmann H, Probert L.

J Immunol. 2004 Dec 1;173(11):6619-26.


Cellular-FLIP, Raji isoform (c-FLIP R) modulates cell death induction upon T-cell activation and infection.

Telieps T, Ewald F, Gereke M, Annemann M, Rauter Y, Schuster M, Ueffing N, von Smolinski D, Gruber AD, Bruder D, Schmitz I.

Eur J Immunol. 2013 Jun;43(6):1499-510. doi: 10.1002/eji.201242819. Epub 2013 May 2.


Up-regulation of cellular FLICE-inhibitory protein in peripheral blood B lymphocytes in patients with systemic lupus erythematosus is associated with clinical characteristics.

Tao J, Dong J, Li Y, Liu YQ, Yang J, Wu Y, Li L, Shen GX, Tan ZJ, Tu YT.

J Eur Acad Dermatol Venereol. 2009 Apr;23(4):433-7. doi: 10.1111/j.1468-3083.2009.03095.x.


Cellular FLIP (long form) regulates CD8+ T cell activation through caspase-8-dependent NF-kappa B activation.

Dohrman A, Kataoka T, Cuenin S, Russell JQ, Tschopp J, Budd RC.

J Immunol. 2005 May 1;174(9):5270-8.


Constitutive expression of murine c-FLIPR causes autoimmunity in aged mice.

Ewald F, Annemann M, Pils MC, Plaza-Sirvent C, Neff F, Erck C, Reinhold D, Schmitz I.

Cell Death Dis. 2014 Apr 10;5:e1168. doi: 10.1038/cddis.2014.138.


Reduced myocarditis following Coxsackievirus infection in cellular FLICE inhibitory protein--long form-transgenic mice.

Huber S, Dohrman A, Sartini D, Budd RC.

Immunology. 2006 Dec;119(4):541-50. Epub 2006 Sep 28.


A role for c-FLIP(L) in the regulation of apoptosis, autophagy, and necroptosis in T lymphocytes.

He MX, He YW.

Cell Death Differ. 2013 Feb;20(2):188-97. doi: 10.1038/cdd.2012.148. Epub 2012 Nov 23.


The caspase 8 inhibitor c-FLIP(L) modulates T-cell receptor-induced proliferation but not activation-induced cell death of lymphocytes.

Lens SM, Kataoka T, Fortner KA, Tinel A, Ferrero I, MacDonald RH, Hahne M, Beermann F, Attinger A, Orbea HA, Budd RC, Tschopp J.

Mol Cell Biol. 2002 Aug;22(15):5419-33.


c-FLICE inhibitory protein expression inhibits T-cell activation.

Tai TS, Fang LW, Lai MZ.

Cell Death Differ. 2004 Jan;11(1):69-79.


c-FLIP(S) reduces activation of caspase and NF-kappaB pathways and decreases T cell survival.

Hinshaw-Makepeace J, Huston G, Fortner KA, Russell JQ, Holoch D, Swain S, Budd RC.

Eur J Immunol. 2008 Jan;38(1):54-63.


Autoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells.

Wu DJ, Zhou W, Enouz S, Orrú V, Stanford SM, Maine CJ, Rapini N, Sawatzke K, Engel I, Fiorillo E, Sherman LA, Kronenberg M, Zehn D, Peterson E, Bottini N.

PLoS One. 2014 Feb 3;9(2):e86677. doi: 10.1371/journal.pone.0086677. eCollection 2014.


A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity.

Hsu LY, Tan YX, Xiao Z, Malissen M, Weiss A.

J Exp Med. 2009 Oct 26;206(11):2527-41. doi: 10.1084/jem.20082902. Epub 2009 Oct 19.


Defective selection of thymic regulatory T cells accompanies autoimmunity and pulmonary infiltrates in Tcra-deficient mice double transgenic for human La/Sjögren's syndrome-B and human La-specific TCR.

Yaciuk JC, Pan Y, Schwarz K, Pan ZJ, Maier-Moore JS, Kosanke SD, Lawrence C, Farris AD.

J Immunol. 2015 Feb 15;194(4):1514-22. doi: 10.4049/jimmunol.1400319. Epub 2015 Jan 12.

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