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Items: 1 to 20 of 409

1.

ATM activates p53 by regulating MDM2 oligomerization and E3 processivity.

Cheng Q, Chen L, Li Z, Lane WS, Chen J.

EMBO J. 2009 Dec 16;28(24):3857-67. doi: 10.1038/emboj.2009.294.

2.

Mechanism of p53 stabilization by ATM after DNA damage.

Cheng Q, Chen J.

Cell Cycle. 2010 Feb 1;9(3):472-8.

3.

DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destruction.

Wang Z, Inuzuka H, Zhong J, Fukushima H, Wan L, Liu P, Wei W.

Oncotarget. 2012 Sep;3(9):1026-35.

4.

ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage.

Dornan D, Shimizu H, Mah A, Dudhela T, Eby M, O'rourke K, Seshagiri S, Dixit VM.

Science. 2006 Aug 25;313(5790):1122-6.

5.

ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage.

Chen L, Gilkes DM, Pan Y, Lane WS, Chen J.

EMBO J. 2005 Oct 5;24(19):3411-22. Epub 2005 Sep 15.

6.

Phosphorylation of Daxx by ATM contributes to DNA damage-induced p53 activation.

Tang J, Agrawal T, Cheng Q, Qu L, Brewer MD, Chen J, Yang X.

PLoS One. 2013;8(2):e55813. doi: 10.1371/journal.pone.0055813. Epub 2013 Feb 6. Erratum in: PLoS One. 2013;8(9). doi:10.1371/annotation/032b026d-5bcf-4c1b-aa15-65c226a53818.

7.

The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop.

Lu X, Ma O, Nguyen TA, Jones SN, Oren M, Donehower LA.

Cancer Cell. 2007 Oct;12(4):342-54.

8.

ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage.

Khoronenkova SV, Dianova II, Ternette N, Kessler BM, Parsons JL, Dianov GL.

Mol Cell. 2012 Mar 30;45(6):801-13. doi: 10.1016/j.molcel.2012.01.021. Epub 2012 Feb 21.

9.

Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage.

Pereg Y, Shkedy D, de Graaf P, Meulmeester E, Edelson-Averbukh M, Salek M, Biton S, Teunisse AF, Lehmann WD, Jochemsen AG, Shiloh Y.

Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5056-61. Epub 2005 Mar 23.

10.

Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage.

Cheng Q, Cross B, Li B, Chen L, Li Z, Chen J.

Mol Cell Biol. 2011 Dec;31(24):4951-63. doi: 10.1128/MCB.05553-11. Epub 2011 Oct 10.

11.

hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage.

Moumen A, Masterson P, O'Connor MJ, Jackson SP.

Cell. 2005 Dec 16;123(6):1065-78.

12.

ATM phosphorylation of Mdm2 Ser394 regulates the amplitude and duration of the DNA damage response in mice.

Gannon HS, Woda BA, Jones SN.

Cancer Cell. 2012 May 15;21(5):668-79. doi: 10.1016/j.ccr.2012.04.011.

13.

RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage.

Fu X, Yucer N, Liu S, Li M, Yi P, Mu JJ, Yang T, Chu J, Jung SY, O'Malley BW, Gu W, Qin J, Wang Y.

Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4579-84. doi: 10.1073/pnas.0912094107. Epub 2010 Feb 19.

14.

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage.

Maya R, Balass M, Kim ST, Shkedy D, Leal JF, Shifman O, Moas M, Buschmann T, Ronai Z, Shiloh Y, Kastan MB, Katzir E, Oren M.

Genes Dev. 2001 May 1;15(9):1067-77.

15.

ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage.

Taira N, Yamamoto H, Yamaguchi T, Miki Y, Yoshida K.

J Biol Chem. 2010 Feb 12;285(7):4909-19. doi: 10.1074/jbc.M109.042341. Epub 2009 Dec 4.

16.

Indole-3-carbinol activates the ATM signaling pathway independent of DNA damage to stabilize p53 and induce G1 arrest of human mammary epithelial cells.

Brew CT, Aronchik I, Hsu JC, Sheen JH, Dickson RB, Bjeldanes LF, Firestone GL.

Int J Cancer. 2006 Feb 15;118(4):857-68.

17.

EDD inhibits ATM-mediated phosphorylation of p53.

Ling S, Lin WC.

J Biol Chem. 2011 Apr 29;286(17):14972-82. doi: 10.1074/jbc.M110.182527. Epub 2011 Mar 7.

18.

ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation.

Meulmeester E, Pereg Y, Shiloh Y, Jochemsen AG.

Cell Cycle. 2005 Sep;4(9):1166-70. Epub 2005 Sep 29. Review.

PMID:
16082221
19.

ATM-mediated phosphorylation activates the tumor-suppressive function of B56γ-PP2A.

Shouse GP, Nobumori Y, Panowicz MJ, Liu X.

Oncogene. 2011 Sep 1;30(35):3755-65. doi: 10.1038/onc.2011.95. Epub 2011 Apr 4.

PMID:
21460856
20.

Autoactivation of the MDM2 E3 ligase by intramolecular interaction.

Cheng Q, Song T, Chen L, Chen J.

Mol Cell Biol. 2014 Aug;34(15):2800-10. doi: 10.1128/MCB.00246-14. Epub 2014 May 19.

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