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19808904,19188161,20008840,19804422,21220474,18513582,22317763,24939008,22736441,23588221,22993320,22789825,22133747,20647329,19010923,19921194,23916913,24631288,22052230,25607753,25483995,17085664,18599154,17145836,22553343,15746062,19632948,26580964,24983493,26063323,24355409,23440266,22592212,26184032,15895392,23507559,22844075,23332287,17909038,15613453,28230005,26124204,22833077,23829935,26711932,24167634,27612490,17549382,17699786,24644001,26554308,25052479,23962905,21767894,17052295,16361555,16103058,19381876,16361577,26334838,23334091,17047074,24636263,21315472,28040594,24192512,22788954,21597390,21053345,17145885,17695517,26845230,24458568,20619923,25969993,19491201,24974831,17575237,26301867,23911281,16052433,23319394,23872583,22089117,21062933,17332333,18093943,18060492,28138027,28396313,17270025,17096850,16278407,26400668,16843263,16906227,24122793,27259997,31077779,18698039,17111370,19671676,22154113,25981168,29393480,25453378,17093937,29378193,17616683,24828661,28829429,23266614,21702662,21687596,25382705,18520300,24946052,17332364,22502680,22213300,25522678,17189395,26919104,24922639,22762482,25638724,24054705,25831463,26891293,24687913,26471306,19096299,26409771,23536707,23045273,28418902,20643778,26190015,25964297,22712764,22722827,22594511,24371262,24842595,15569985,16009451,27270313,26898612,20388064,18381447,24953979,26202045,26160838,26150526,24324054,24223799,25117641,28422737,24297483,18334834,27091996,24698130,17888033,23592446,16333527,24615768,16177282,25338771,26389761,16675591,25634113,16890793,25724832,17335935,22883469,20085869,15761868,19843665,17575145,21640718,15851741,26943330,19181917,21252719,25198658,25807554,17611677,26980747,23523951,18832819,27599579,23102728,25936890,28442019,22751098,24573033,20736805,24921970,21159609,18451158,30429039,16489045,24575658,31132355,34370268,18192072,22815900,24339922,29119113,20404520,23360489,21549910,29505507,22715590,26828195,21499124,26667342,28396596,26268703,20363215,25963923,24795011,21128242,21960227,27816965,28683123,16187797,25561332,15604284,34233230,12792773,26206867,25482142,28314274,18821783,16288045,25875914,32440811,29386539,24033722,21168239,23312887,24518715,21777765,16912195,23513863,27873490,31747941,25486409,26001148,16850125,17463250,28446239,23810268,19381026,18497962,31470227,28485480,27930974,20007486,23765757,23489694,25668228,23677180,24565584,30309221,17495520,24986519,29664235,16113094,27863726,25724261,18754874,25310337,27690301,26381735,31131689,26453958,18625569,22238368,26936292,22285130,27042857,17346275,16955736,19189656,23213056,25948633,16189524,28115165,18588508,28754471,28946557,26214645,26281693,29221754,30075033,28818608,24448239,19240716,24389444,21443472,23045285,33763171,29570930,27515192,32395869,28782530,23690929,25530180,25780909,30824185,19414383,25445223,25342043,25656847,21487020,24922647,27325282,18564139,28469968,31960422,27070423,28584208,23453860,28978341,30480362,21555162,22178131,32234873,33952462,23720767,32034073,26461476,23953842,19620837,21187468,27487128,19573800,25446083,27694386,18316192,26408683,26125777,29594878,25482516,25893986,29137977,25511614,26543351,29714661,16786133,19235590,20560975,25971727,28787156,27285768,15955594,20934974,22435662,27029054,21045138,22129360,31279006,25353970,28396363,25948104,24280348,26439378,30674502,25983263,20026433,23792318,26983447,25510664,25855012,29121501,26500058,16030296,31109434,23345546,19938898,20146583,26968253,26542452,24463098,27558531,15870427,31561203,29802456,25382203,28440510,26288223,28193529,26000960,23568717,31342590,18180459,28915640,28064454,22170031,28781659,28887613,15660382,26781210,19620791,24888374,27299185,21617791,25473895,27279914,30174307,24903273,19379648,23327866,28504890,34516823,32615820,24354805,15922858,29154817,26863629,16231326,27716616,23794705,17289870,26706953,25301240,20154724,23973484,19189657,17367921,20841479,28899783,35377279,22263058,29050315,28362115,26496080,18413259,32429639,29455669,16765644,28460611,29141884,16927343,23794184,21697284,29981430,26762413,31869496,23552882,21840303,25381815,29455655,24246676,31817278,23106397,24827412,25884419,24836441,21606217,31606039,27524418,36464873,24490607,29551767,25260782,26215852,24810090,28630215,22236672,24638075,36066413,27936599,27794612,33829354,31339210,26319934,29812969,22335886,27491651,27421137,25992380,27920137,25503644,23533466,23324306,34657484,26432108,25319899,35326664,14641988,26988570,27401557,20500904,25681445,32169477,16357520,30638795,23200895,25563590,28167502,27655711,23277288,28373408,27185371,29207630,27188602,28424065,29875142,26384434,23993328,25978031,25521406,27435393,26238631,15695376,33638808,32976979,31255653,32030757,23536719,17259562,16461907,25011627,22115753,17045403,27717823,28679766,24384534,33151388,34112110,29103264,30792648,23307858,15229590,23401458,25865310,27613843,25426675,26812910,25914548,23402326,35027025,30760701,25979753,32393528,34550531,23930994,31069942,15688607,11129168,31557260,25202264,22005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The role of MET activation in determining the sensitivity to epidermal growth factor receptor tyrosine kinase inhibitors.

Rho JK, Choi YJ, Lee JK, Ryoo BY, Na II, Yang SH, Lee SS, Kim CH, Yoo YD, Lee JC. Rho JK, et al. Mol Cancer Res. 2009 Oct;7(10):1736-43. doi: 10.1158/1541-7786.MCR-08-0504. Epub 2009 Oct 6. Mol Cancer Res. 2009. PMID: 19808904

Addition of S-1 to the epidermal growth factor receptor inhibitor gefitinib overcomes gefitinib resistance in non-small cell lung cancer cell lines with MET amplification.

Okabe T, Okamoto I, Tsukioka S, Uchida J, Hatashita E, Yamada Y, Yoshida T, Nishio K, Fukuoka M, Jänne PA, Nakagawa K. Okabe T, et al. Clin Cancer Res. 2009 Feb 1;15(3):907-13. doi: 10.1158/1078-0432.CCR-08-2251. Clin Cancer Res. 2009. PMID: 19188161

Hepatocyte growth factor reduces susceptibility to an irreversible epidermal growth factor receptor inhibitor in EGFR-T790M mutant lung cancer.

Yamada T, Matsumoto K, Wang W, Li Q, Nishioka Y, Sekido Y, Sone S, Yano S. Yamada T, et al. Clin Cancer Res. 2010 Jan 1;16(1):174-83. doi: 10.1158/1078-0432.CCR-09-1204. Epub 2009 Dec 15. Clin Cancer Res. 2010. PMID: 20008840

Effects of Src inhibitors on cell growth and epidermal growth factor receptor and MET signaling in gefitinib-resistant non-small cell lung cancer cells with acquired MET amplification.

Yoshida T, Okamoto I, Okamoto W, Hatashita E, Yamada Y, Kuwata K, Nishio K, Fukuoka M, Jänne PA, Nakagawa K. Yoshida T, et al. Cancer Sci. 2010 Jan;101(1):167-72. doi: 10.1111/j.1349-7006.2009.01368.x. Epub 2009 Sep 14. Cancer Sci. 2010. PMID: 19804422 Free article.

Transient PI3K inhibition induces apoptosis and overcomes HGF-mediated resistance to EGFR-TKIs in EGFR mutant lung cancer.

Donev IS, Wang W, Yamada T, Li Q, Takeuchi S, Matsumoto K, Yamori T, Nishioka Y, Sone S, Yano S. Donev IS, et al. Clin Cancer Res. 2011 Apr 15;17(8):2260-9. doi: 10.1158/1078-0432.CCR-10-1993. Epub 2011 Jan 10. Clin Cancer Res. 2011. PMID: 21220474

Challenges of detecting EGFR T790M in gefitinib/erlotinib-resistant tumours.

Jänne PA. Jänne PA. Lung Cancer. 2008 Jun;60 Suppl 2:S3-9. doi: 10.1016/S0169-5002(08)70099-0. Lung Cancer. 2008. PMID: 18513582 Review.

Met kinase inhibitor E7050 reverses three different mechanisms of hepatocyte growth factor-induced tyrosine kinase inhibitor resistance in EGFR mutant lung cancer.

Wang W, Li Q, Takeuchi S, Yamada T, Koizumi H, Nakamura T, Matsumoto K, Mukaida N, Nishioka Y, Sone S, Nakagawa T, Uenaka T, Yano S. Wang W, et al. Clin Cancer Res. 2012 Mar 15;18(6):1663-71. doi: 10.1158/1078-0432.CCR-11-1171. Epub 2012 Feb 8. Clin Cancer Res. 2012. PMID: 22317763 Free article.

CRKL amplification is rare as a mechanism for acquired resistance to kinase inhibitors in lung cancers with epidermal growth factor receptor mutation.

Suda K, Mizuuchi H, Murakami I, Uramoto H, Tanaka F, Sato K, Takemoto T, Iwasaki T, Sekido Y, Yatabe Y, Mitsudomi T. Suda K, et al. Lung Cancer. 2014 Aug;85(2):147-51. doi: 10.1016/j.lungcan.2014.05.018. Epub 2014 Jun 2. Lung Cancer. 2014. PMID: 24939008

Acquired resistance mechanisms to tyrosine kinase inhibitors in lung cancer with activating epidermal growth factor receptor mutation--diversity, ductility, and destiny.

Suda K, Mizuuchi H, Maehara Y, Mitsudomi T. Suda K, et al. Cancer Metastasis Rev. 2012 Dec;31(3-4):807-14. doi: 10.1007/s10555-012-9391-7. Cancer Metastasis Rev. 2012. PMID: 22736441 Review.

Knockdown of the Bcl-2 gene increases sensitivity to EGFR tyrosine kinase inhibitors in the H1975 lung cancer cell line harboring T790M mutation.

Zou M, Xia S, Zhuang L, Han N, Chu Q, Chao T, Peng P, Chen Y, Gui Q, Yu S. Zou M, et al. Int J Oncol. 2013 Jun;42(6):2094-102. doi: 10.3892/ijo.2013.1895. Epub 2013 Apr 12. Int J Oncol. 2013. PMID: 23588221

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