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Items: 1 to 20 of 91

1.

Mammalian glutaminyl cyclases and their isoenzymes have identical enzymatic characteristics.

Stephan A, Wermann M, von Bohlen A, Koch B, Cynis H, Demuth HU, Schilling S.

FEBS J. 2009 Nov;276(22):6522-36. doi: 10.1111/j.1742-4658.2009.07337.x. Epub 2009 Oct 5.

2.

Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery.

Cynis H, Rahfeld JU, Stephan A, Kehlen A, Koch B, Wermann M, Demuth HU, Schilling S.

J Mol Biol. 2008 Jun 20;379(5):966-80. doi: 10.1016/j.jmb.2008.03.078. Epub 2008 Apr 15.

PMID:
18486145
3.

Isolation and characterization of glutaminyl cyclases from Drosophila: evidence for enzyme forms with different subcellular localization.

Schilling S, Lindner C, Koch B, Wermann M, Rahfeld JU, von Bohlen A, Rudolph T, Reuter G, Demuth HU.

Biochemistry. 2007 Sep 25;46(38):10921-30. Epub 2007 Aug 28.

PMID:
17722885
4.

Isolation and characterization of the glutaminyl cyclases from Solanum tuberosum and Arabidopsis thaliana: implications for physiological functions.

Schilling S, Stenzel I, von Bohlen A, Wermann M, Schulz K, Demuth HU, Wasternack C.

Biol Chem. 2007 Feb;388(2):145-53.

PMID:
17261077
5.

Heterologous expression and characterization of human glutaminyl cyclase: evidence for a disulfide bond with importance for catalytic activity.

Schilling S, Hoffmann T, Rosche F, Manhart S, Wasternack C, Demuth HU.

Biochemistry. 2002 Sep 3;41(35):10849-57.

PMID:
12196024
6.

Isolation, catalytic properties, and competitive inhibitors of the zinc-dependent murine glutaminyl cyclase.

Schilling S, Cynis H, von Bohlen A, Hoffmann T, Wermann M, Heiser U, Buchholz M, Zunkel K, Demuth HU.

Biochemistry. 2005 Oct 11;44(40):13415-24.

PMID:
16201766
7.

Structures of glycosylated mammalian glutaminyl cyclases reveal conformational variability near the active center.

Ruiz-Carrillo D, Koch B, Parthier C, Wermann M, Dambe T, Buchholz M, Ludwig HH, Heiser U, Rahfeld JU, Stubbs MT, Schilling S, Demuth HU.

Biochemistry. 2011 Jul 19;50(28):6280-8. doi: 10.1021/bi200249h. Epub 2011 Jun 27.

PMID:
21671571
8.

Mouse strain and brain region-specific expression of the glutaminyl cyclases QC and isoQC.

Höfling C, Indrischek H, Höpcke T, Waniek A, Cynis H, Koch B, Schilling S, Morawski M, Demuth HU, Roßner S, Hartlage-Rübsamen M.

Int J Dev Neurosci. 2014 Aug;36:64-73. doi: 10.1016/j.ijdevneu.2014.05.008. Epub 2014 Jun 2.

PMID:
24886834
9.

IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes.

Becker A, Eichentopf R, Sedlmeier R, Waniek A, Cynis H, Koch B, Stephan A, Bäuscher C, Kohlmann S, Hoffmann T, Kehlen A, Berg S, Freyse EJ, Osmand A, Plank AC, Roßner S, von Hörsten S, Graubner S, Demuth HU, Schilling S.

Biol Chem. 2016 Jan;397(1):45-55. doi: 10.1515/hsz-2015-0192.

PMID:
26351917
10.

Crystal structures of glutaminyl cyclases (QCs) from Drosophila melanogaster reveal active site conservation between insect and mammalian QCs.

Koch B, Kolenko P, Buchholz M, Carrillo DR, Parthier C, Wermann M, Rahfeld JU, Reuter G, Schilling S, Stubbs MT, Demuth HU.

Biochemistry. 2012 Sep 18;51(37):7383-92. doi: 10.1021/bi300687g. Epub 2012 Sep 5.

PMID:
22897232
11.

Evidence for essential histidines in human pituitary glutaminyl cyclase.

Bateman RC Jr, Temple JS, Misquitta SA, Booth RE.

Biochemistry. 2001 Sep 18;40(37):11246-50.

PMID:
11551224
12.

Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions.

Schilling S, Hoffmann T, Manhart S, Hoffmann M, Demuth HU.

FEBS Lett. 2004 Apr 9;563(1-3):191-6.

13.

Glutaminyl cyclases from animals and plants: a case of functionally convergent protein evolution.

Schilling S, Wasternack C, Demuth HU.

Biol Chem. 2008 Aug;389(8):983-91. doi: 10.1515/BC.2008.111. Review.

PMID:
18979624
14.

Crystal structure and functional analysis of the glutaminyl cyclase from Xanthomonas campestris.

Huang WL, Wang YR, Ko TP, Chia CY, Huang KF, Wang AH.

J Mol Biol. 2010 Aug 20;401(3):374-88. doi: 10.1016/j.jmb.2010.06.012. Epub 2010 Jun 15.

PMID:
20558177
15.

Carica papaya glutamine cyclotransferase belongs to a novel plant enzyme subfamily: cloning and characterization of the recombinant enzyme.

Dahl SW, Slaughter C, Lauritzen C, Bateman RC Jr, Connerton I, Pedersen J.

Protein Expr Purif. 2000 Oct;20(1):27-36.

PMID:
11035947
16.

Inhibition of Glutaminyl Cyclases alleviates CCL2-mediated inflammation of non-alcoholic fatty liver disease in mice.

Cynis H, Kehlen A, Haegele M, Hoffmann T, Heiser U, Fujii M, Shibazaki Y, Yoneyama H, Schilling S, Demuth HU.

Int J Exp Pathol. 2013 Jun;94(3):217-25. doi: 10.1111/iep.12020. Epub 2013 Apr 8.

17.

Glutaminyl cyclases display significant catalytic proficiency for glutamyl substrates.

Seifert F, Schulz K, Koch B, Manhart S, Demuth HU, Schilling S.

Biochemistry. 2009 Dec 22;48(50):11831-3. doi: 10.1021/bi9018835.

PMID:
19921850
18.

Glutaminyl cyclase knock-out mice exhibit slight hypothyroidism but no hypogonadism: implications for enzyme function and drug development.

Schilling S, Kohlmann S, Bäuscher C, Sedlmeier R, Koch B, Eichentopf R, Becker A, Cynis H, Hoffmann T, Berg S, Freyse EJ, von Hörsten S, Rossner S, Graubner S, Demuth HU.

J Biol Chem. 2011 Apr 22;286(16):14199-208. doi: 10.1074/jbc.M111.229385. Epub 2011 Feb 17.

19.

Structural and functional analyses of a glutaminyl cyclase from Ixodes scapularis reveal metal-independent catalysis and inhibitor binding.

Huang KF, Hsu HL, Karim S, Wang AH.

Acta Crystallogr D Biol Crystallogr. 2014 Mar;70(Pt 3):789-801. doi: 10.1107/S1399004713033488. Epub 2014 Feb 22.

PMID:
24598748
20.

Crystal structure of papaya glutaminyl cyclase, an archetype for plant and bacterial glutaminyl cyclases.

Wintjens R, Belrhali H, Clantin B, Azarkan M, Bompard C, Baeyens-Volant D, Looze Y, Villeret V.

J Mol Biol. 2006 Mar 24;357(2):457-70. Epub 2006 Jan 4.

PMID:
16438985

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