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Items: 1 to 20 of 135

1.

A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage.

Cortes Ledesma F, El Khamisy SF, Zuma MC, Osborn K, Caldecott KW.

Nature. 2009 Oct 1;461(7264):674-8. doi: 10.1038/nature08444.

PMID:
19794497
2.

TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.

Zeng Z, Sharma A, Ju L, Murai J, Umans L, Vermeire L, Pommier Y, Takeda S, Huylebroeck D, Caldecott KW, El-Khamisy SF.

Nucleic Acids Res. 2012 Sep 1;40(17):8371-80. Epub 2012 Jun 26.

3.

TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage.

Zeng Z, Cortés-Ledesma F, El Khamisy SF, Caldecott KW.

J Biol Chem. 2011 Jan 7;286(1):403-9. doi: 10.1074/jbc.M110.181016. Epub 2010 Oct 28.

4.

TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo.

Gómez-Herreros F, Romero-Granados R, Zeng Z, Alvarez-Quilón A, Quintero C, Ju L, Umans L, Vermeire L, Huylebroeck D, Caldecott KW, Cortés-Ledesma F.

PLoS Genet. 2013;9(3):e1003226. doi: 10.1371/journal.pgen.1003226. Epub 2013 Mar 7.

5.

Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells.

Murai J, Huang SY, Das BB, Dexheimer TS, Takeda S, Pommier Y.

J Biol Chem. 2012 Apr 13;287(16):12848-57. doi: 10.1074/jbc.M111.333963. Epub 2012 Feb 27.

6.

Depletion of tyrosyl DNA phosphodiesterase 2 activity enhances etoposide-mediated double-strand break formation and cell killing.

Kont YS, Dutta A, Mallisetty A, Mathew J, Minas T, Kraus C, Dhopeshwarkar P, Kallakury B, Mitra S, Üren A, Adhikari S.

DNA Repair (Amst). 2016 Jul;43:38-47. doi: 10.1016/j.dnarep.2016.04.009. Epub 2016 May 7.

PMID:
27235629
7.

Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage.

Nitiss KC, Malik M, He X, White SW, Nitiss JL.

Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):8953-8. Epub 2006 Jun 2.

8.

TDP1 overexpression in human cells counteracts DNA damage mediated by topoisomerases I and II.

Barthelmes HU, Habermeyer M, Christensen MO, Mielke C, Interthal H, Pouliot JJ, Boege F, Marko D.

J Biol Chem. 2004 Dec 31;279(53):55618-25. Epub 2004 Oct 19.

9.

Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin.

El-Khamisy SF, Katyal S, Patel P, Ju L, McKinnon PJ, Caldecott KW.

DNA Repair (Amst). 2009 Jun 4;8(6):760-6. doi: 10.1016/j.dnarep.2009.02.002. Epub 2009 Mar 19.

10.

Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).

Pommier Y, Huang SY, Gao R, Das BB, Murai J, Marchand C.

DNA Repair (Amst). 2014 Jul;19:114-29. doi: 10.1016/j.dnarep.2014.03.020. Epub 2014 May 22. Review.

11.

Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1.

El-Khamisy SF, Saifi GM, Weinfeld M, Johansson F, Helleday T, Lupski JR, Caldecott KW.

Nature. 2005 Mar 3;434(7029):108-13.

PMID:
15744309
12.
13.

Generation of assays and antibodies to facilitate the study of human 5'-tyrosyl DNA phosphodiesterase.

Thomson G, Watson A, Caldecott K, Denneny O, Depledge P, Hamilton N, Hopkins G, Jordan A, Morrow C, Raoof A, Waddell I, Ogilvie D.

Anal Biochem. 2013 May 15;436(2):145-50. doi: 10.1016/j.ab.2013.02.001. Epub 2013 Feb 12.

PMID:
23416181
14.

Role of tyrosyl-DNA phosphodiesterase 1 and inter-players in regulation of tumor cell sensitivity to topoisomerase I inhibition.

Perego P, Cossa G, Tinelli S, Corna E, Carenini N, Gatti L, De Cesare M, Ciusani E, Zunino F, Luison E, Canevari S, Zaffaroni N, Beretta GL.

Biochem Pharmacol. 2012 Jan 1;83(1):27-36. doi: 10.1016/j.bcp.2011.09.021. Epub 2011 Sep 29.

PMID:
21978643
15.

Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks.

Zhou T, Akopiants K, Mohapatra S, Lin PS, Valerie K, Ramsden DA, Lees-Miller SP, Povirk LF.

DNA Repair (Amst). 2009 Aug 6;8(8):901-11. doi: 10.1016/j.dnarep.2009.05.003. Epub 2009 Jun 7.

16.

Repair of topoisomerase I covalent complexes in the absence of the tyrosyl-DNA phosphodiesterase Tdp1.

Liu C, Pouliot JJ, Nash HA.

Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14970-5. Epub 2002 Oct 23.

17.

Hereditary ataxia SCAN1 cells are defective for the repair of transcription-dependent topoisomerase I cleavage complexes.

Miao ZH, Agama K, Sordet O, Povirk L, Kohn KW, Pommier Y.

DNA Repair (Amst). 2006 Dec 9;5(12):1489-94. Epub 2006 Aug 28.

PMID:
16935573
18.

FEN1 participates in repair of the 5'-phosphotyrosyl terminus of DNA single-strand breaks.

Kametani Y, Takahata C, Narita T, Tanaka K, Iwai S, Kuraoka I.

Carcinogenesis. 2016 Jan;37(1):56-62. doi: 10.1093/carcin/bgv159. Epub 2015 Nov 17.

PMID:
26581212
19.

SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair.

Hudson JJ, Chiang SC, Wells OS, Rookyard C, El-Khamisy SF.

Nat Commun. 2012 Mar 13;3:733. doi: 10.1038/ncomms1739.

20.

Pathways for repair of topoisomerase I covalent complexes in Saccharomyces cerevisiae.

Pouliot JJ, Robertson CA, Nash HA.

Genes Cells. 2001 Aug;6(8):677-87.

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