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Items: 1 to 20 of 98

1.

Pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione derivatives: their cytoprotection effect from rotenone toxicity and preliminary DMPK properties.

Zhou Y, Liu G, Chen J, Reddy PS, Yoon IS, Zhang M, Zhang B, Barber JR, Ng SC.

Bioorg Med Chem Lett. 2009 Nov 1;19(21):6114-8. doi: 10.1016/j.bmcl.2009.09.021. Epub 2009 Sep 10.

PMID:
19786349
2.

Pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione derivatives as novel small molecule chaperone amplifiers.

Zhou Y, Wei L, Brady TP, Murali Mohan Redddy PS, Nguyen T, Chen J, Au Q, Yoon IS, Yip G, Zhang B, Barber JR, Ng SC.

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4303-7. doi: 10.1016/j.bmcl.2009.05.073. Epub 2009 May 27.

PMID:
19502057
3.

Rotenone, deguelin, their metabolites, and the rat model of Parkinson's disease.

Caboni P, Sherer TB, Zhang N, Taylor G, Na HM, Greenamyre JT, Casida JE.

Chem Res Toxicol. 2004 Nov;17(11):1540-8.

PMID:
15540952
4.

Discovery of triazines as potent, selective and orally active PDE4 inhibitors.

Gewald R, Grunwald C, Egerland U.

Bioorg Med Chem Lett. 2013 Aug 1;23(15):4308-14. doi: 10.1016/j.bmcl.2013.05.099. Epub 2013 Jun 10.

PMID:
23806553
5.

Neoechinulin a impedes the progression of rotenone-induced cytotoxicity in PC12 cells.

Akashi S, Kimura T, Takeuchi T, Kuramochi K, Kobayashi S, Sugawara F, Watanabe N, Arai T.

Biol Pharm Bull. 2011;34(2):243-8.

6.

Novel bicyclic piperazine derivatives of triazolotriazine and triazolopyrimidines as highly potent and selective adenosine A2A receptor antagonists.

Peng H, Kumaravel G, Yao G, Sha L, Wang J, Van Vlijmen H, Bohnert T, Huang C, Vu CB, Ensinger CL, Chang H, Engber TM, Whalley ET, Petter RC.

J Med Chem. 2004 Dec 2;47(25):6218-29.

PMID:
15566292
7.

Piperazine derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine as potent and selective adenosine A2a receptor antagonists.

Vu CB, Peng B, Kumaravel G, Smits G, Jin X, Phadke D, Engber T, Huang C, Reilly J, Tam S, Grant D, Hetu G, Chen L, Zhang J, Petter RC.

J Med Chem. 2004 Aug 12;47(17):4291-9.

PMID:
15294001
8.

Synthesis, antioxidant activity and structure-activity relationships for a new series of 2-(N-acylaminoethyl)indoles with melatonin-like cytoprotective activity.

Spadoni G, Diamantini G, Bedini A, Tarzia G, Vacondio F, Silva C, Rivara M, Mor M, Plazzi PV, Zusso M, Franceschini D, Giusti P.

J Pineal Res. 2006 Apr;40(3):259-69.

PMID:
16499563
9.

Effect of centrophenoxine against rotenone-induced oxidative stress in an animal model of Parkinson's disease.

Verma R, Nehru B.

Neurochem Int. 2009 Nov;55(6):369-75. doi: 10.1016/j.neuint.2009.04.001. Epub 2009 Apr 16.

PMID:
19375462
10.
11.

Enhanced sensitivity of dopaminergic neurons to rotenone-induced toxicity with aging.

Phinney AL, Andringa G, Bol JG, Wolters ECh, van Muiswinkel FL, van Dam AM, Drukarch B.

Parkinsonism Relat Disord. 2006 May;12(4):228-38. Epub 2006 Feb 20.

PMID:
16488175
12.

Selective microglial activation in the rat rotenone model of Parkinson's disease.

Sherer TB, Betarbet R, Kim JH, Greenamyre JT.

Neurosci Lett. 2003 May 1;341(2):87-90.

PMID:
12686372
13.

4-(1,3-Dimethoxyprop-2-ylamino)-2,7-dimethyl-8-(2, 4-dichlorophenyl)pyrazolo[1,5-a]-1,3,5-triazine: a potent, orally bioavailable CRF(1) receptor antagonist.

He L, Gilligan PJ, Zaczek R, Fitzgerald LW, McElroy J, Shen HS, Saye JA, Kalin NH, Shelton S, Christ D, Trainor G, Hartig P.

J Med Chem. 2000 Feb 10;43(3):449-56.

PMID:
10669572
14.
15.

Design, synthesis, and anti-inflammatory properties of orally active 4-(phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38alpha mitogen-activated protein kinase inhibitors.

Hynes J Jr, Dyckman AJ, Lin S, Wrobleski ST, Wu H, Gillooly KM, Kanner SB, Lonial H, Loo D, McIntyre KW, Pitt S, Shen DR, Shuster DJ, Yang X, Zhang R, Behnia K, Zhang H, Marathe PH, Doweyko AM, Tokarski JS, Sack JS, Pokross M, Kiefer SE, Newitt JA, Barrish JC, Dodd J, Schieven GL, Leftheris K.

J Med Chem. 2008 Jan 10;51(1):4-16. Epub 2007 Dec 12.

PMID:
18072718
16.

Synthesis and SAR of 4-(3-hydroxyphenylamino)pyrrolo[2,1-f][1,2,4]triazine based VEGFR-2 kinase inhibitors.

Borzilleri RM, Cai ZW, Ellis C, Fargnoli J, Fura A, Gerhardt T, Goyal B, Hunt JT, Mortillo S, Qian L, Tokarski J, Vyas V, Wautlet B, Zheng X, Bhide RS.

Bioorg Med Chem Lett. 2005 Mar 1;15(5):1429-33.

PMID:
15713401
17.

Fraxetin prevents rotenone-induced apoptosis by induction of endogenous glutathione in human neuroblastoma cells.

Sánchez-Reus MI, Peinado II, Molina-Jiménez MF, Benedí J.

Neurosci Res. 2005 Sep;53(1):48-56.

PMID:
15996779
18.

Joint toxicity of triazine herbicides and organophosphate insecticides to the midge Chironomus tentans.

Schuler LJ, Trimble AJ, Belden JB, Lydy MJ.

Arch Environ Contam Toxicol. 2005 Aug;49(2):173-7. Epub 2005 Jun 28.

PMID:
15988628
19.

Design, synthesis, and evaluation of pyrrolo[2,1-f][1,2,4]triazine derivatives as novel hedgehog signaling pathway inhibitors.

Xin M, Zhang L, Tang F, Tu C, Wen J, Zhao X, Liu Z, Cheng L, Shen H.

Bioorg Med Chem. 2014 Feb 15;22(4):1429-40. doi: 10.1016/j.bmc.2013.12.055. Epub 2014 Jan 3.

PMID:
24486203
20.

Triazine and pyrimidine based ROCK inhibitors with efficacy in spontaneous hypertensive rat model.

Ho KK, Beasley JR, Belanger L, Black D, Chan JH, Dunn D, Hu B, Klon A, Kultgen SG, Ohlmeyer M, Parlato SM, Ray PC, Pham Q, Rong Y, Roughton AL, Walker TL, Wright J, Xu K, Xu Y, Zhang L, Webb M.

Bioorg Med Chem Lett. 2009 Nov 1;19(21):6027-31. doi: 10.1016/j.bmcl.2009.09.046. Epub 2009 Sep 17.

PMID:
19800787

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