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Items: 1 to 20 of 95

1.

Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase.

Cai Z, Chehab NH, Pavletich NP.

Mol Cell. 2009 Sep 24;35(6):818-29. doi: 10.1016/j.molcel.2009.09.007.

2.

Characterization of tumor-associated Chk2 mutations.

Wu X, Webster SR, Chen J.

J Biol Chem. 2001 Jan 26;276(4):2971-4. Epub 2000 Oct 26.

3.

Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage.

Bahassi el M, Myer DL, McKenney RJ, Hennigan RF, Stambrook PJ.

Mutat Res. 2006 Apr 11;596(1-2):166-76. Epub 2006 Feb 14.

PMID:
16481012
4.

Exploring the intramolecular phosphorylation sites in human Chk2.

Olsen BB, Larsen MR, Boldyreff B, Niefind K, Issinger OG.

Mutat Res. 2008 Nov 10;646(1-2):50-9. doi: 10.1016/j.mrfmmm.2008.09.002. Epub 2008 Sep 11.

PMID:
18812180
5.

Regulation of the Chk2 protein kinase by oligomerization-mediated cis- and trans-phosphorylation.

Schwarz JK, Lovly CM, Piwnica-Worms H.

Mol Cancer Res. 2003 Jun;1(8):598-609.

6.

Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange.

Oliver AW, Paul A, Boxall KJ, Barrie SE, Aherne GW, Garrett MD, Mittnacht S, Pearl LH.

EMBO J. 2006 Jul 12;25(13):3179-90. Epub 2006 Jun 22.

7.

Chk2 oligomerization studied by phosphopeptide ligation: implications for regulation and phosphodependent interactions.

Li J, Taylor IA, Lloyd J, Clapperton JA, Howell S, MacMillan D, Smerdon SJ.

J Biol Chem. 2008 Dec 19;283(51):36019-30. doi: 10.1074/jbc.M804075200. Epub 2008 Oct 23.

8.

MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways.

Lou Z, Minter-Dykhouse K, Wu X, Chen J.

Nature. 2003 Feb 27;421(6926):957-61.

PMID:
12607004
9.

A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases.

Pirruccello M, Sondermann H, Pelton JG, Pellicena P, Hoelz A, Chernoff J, Wemmer DE, Kuriyan J.

J Mol Biol. 2006 Aug 11;361(2):312-26. Epub 2006 Jun 27.

PMID:
16837009
10.

E2F1 uses the ATM signaling pathway to induce p53 and Chk2 phosphorylation and apoptosis.

Powers JT, Hong S, Mayhew CN, Rogers PM, Knudsen ES, Johnson DG.

Mol Cancer Res. 2004 Apr;2(4):203-14.

11.

Chk2 activation and phosphorylation-dependent oligomerization.

Xu X, Tsvetkov LM, Stern DF.

Mol Cell Biol. 2002 Jun;22(12):4419-32.

12.

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex.

Lee JH, Paull TT.

Science. 2005 Apr 22;308(5721):551-4. Epub 2005 Mar 24. Erratum in: Science. 2005 Jun 24;308(5730):1870.

13.

Activation segment exchange: a common mechanism of kinase autophosphorylation?

Oliver AW, Knapp S, Pearl LH.

Trends Biochem Sci. 2007 Aug;32(8):351-6. Epub 2007 Jul 12.

PMID:
17627826
14.

Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity.

Zhou BB, Chaturvedi P, Spring K, Scott SP, Johanson RA, Mishra R, Mattern MR, Winkler JD, Khanna KK.

J Biol Chem. 2000 Apr 7;275(14):10342-8.

15.

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro.

Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ.

Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10389-94.

17.
18.

The Chk2 protein kinase.

Ahn J, Urist M, Prives C.

DNA Repair (Amst). 2004 Aug-Sep;3(8-9):1039-47. Review.

PMID:
15279791
20.

Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner.

Gibson SL, Bindra RS, Glazer PM.

Cancer Res. 2005 Dec 1;65(23):10734-41.

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