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Items: 1 to 20 of 115

1.

Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle.

Kang JE, Lim MM, Bateman RJ, Lee JJ, Smyth LP, Cirrito JR, Fujiki N, Nishino S, Holtzman DM.

Science. 2009 Nov 13;326(5955):1005-7. doi: 10.1126/science.1180962. Epub 2009 Sep 24.

2.

Effects of growth hormone-releasing hormone on sleep and brain interstitial fluid amyloid-β in an APP transgenic mouse model.

Liao F, Zhang TJ, Mahan TE, Jiang H, Holtzman DM.

Brain Behav Immun. 2015 Jul;47:163-71. doi: 10.1016/j.bbi.2014.09.005. Epub 2014 Sep 16.

3.

Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer's disease.

Roh JH, Jiang H, Finn MB, Stewart FR, Mahan TE, Cirrito JR, Heda A, Snider BJ, Li M, Yanagisawa M, de Lecea L, Holtzman DM.

J Exp Med. 2014 Dec 15;211(13):2487-96. doi: 10.1084/jem.20141788. Epub 2014 Nov 24. Erratum in: J Exp Med. 2015 Jan 12;212(1):121.

4.

Disruption of the sleep-wake cycle and diurnal fluctuation of β-amyloid in mice with Alzheimer's disease pathology.

Roh JH, Huang Y, Bero AW, Kasten T, Stewart FR, Bateman RJ, Holtzman DM.

Sci Transl Med. 2012 Sep 5;4(150):150ra122. doi: 10.1126/scitranslmed.3004291.

5.

Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formation.

Hong S, Quintero-Monzon O, Ostaszewski BL, Podlisny DR, Cavanaugh WT, Yang T, Holtzman DM, Cirrito JR, Selkoe DJ.

J Neurosci. 2011 Nov 2;31(44):15861-9. doi: 10.1523/JNEUROSCI.3272-11.2011.

6.

The dual orexin receptor antagonist almorexant induces sleep and decreases orexin-induced locomotion by blocking orexin 2 receptors.

Mang GM, Dürst T, Bürki H, Imobersteg S, Abramowski D, Schuepbach E, Hoyer D, Fendt M, Gee CE.

Sleep. 2012 Dec 1;35(12):1625-35. doi: 10.5665/sleep.2232.

7.

Characterization of sleep-wake patterns in a novel transgenic mouse line overexpressing human prepro-orexin/hypocretin.

Mäkelä KA, Wigren HK, Zant JC, Sakurai T, Alhonen L, Kostin A, Porkka-Heiskanen T, Herzig KH.

Acta Physiol (Oxf). 2010 Mar;198(3):237-49. doi: 10.1111/j.1748-1716.2009.02068.x. Epub 2009 Dec 10.

PMID:
20003098
8.

Contribution of orexin in hypercapnic chemoreflex: evidence from genetic and pharmacological disruption and supplementation studies in mice.

Deng BS, Nakamura A, Zhang W, Yanagisawa M, Fukuda Y, Kuwaki T.

J Appl Physiol (1985). 2007 Nov;103(5):1772-9. Epub 2007 Aug 23.

9.

The regulation of sleep and wakefulness by the hypothalamic neuropeptide orexin/hypocretin.

Inutsuka A, Yamanaka A.

Nagoya J Med Sci. 2013 Feb;75(1-2):29-36. Review.

10.

Antagonism of rat orexin receptors by almorexant attenuates central chemoreception in wakefulness in the active period of the diurnal cycle.

Li A, Nattie E.

J Physiol. 2010 Aug 1;588(Pt 15):2935-44. doi: 10.1113/jphysiol.2010.191288. Epub 2010 Jun 14.

11.

Delayed orexin signaling consolidates wakefulness and sleep: physiology and modeling.

Diniz Behn CG, Kopell N, Brown EN, Mochizuki T, Scammell TE.

J Neurophysiol. 2008 Jun;99(6):3090-103. doi: 10.1152/jn.01243.2007. Epub 2008 Apr 16.

12.

Differential roles of orexin receptor-1 and -2 in the regulation of non-REM and REM sleep.

Mieda M, Hasegawa E, Kisanuki YY, Sinton CM, Yanagisawa M, Sakurai T.

J Neurosci. 2011 Apr 27;31(17):6518-26. doi: 10.1523/JNEUROSCI.6506-10.2011.

13.

Promotion of sleep by targeting the orexin system in rats, dogs and humans.

Brisbare-Roch C, Dingemanse J, Koberstein R, Hoever P, Aissaoui H, Flores S, Mueller C, Nayler O, van Gerven J, de Haas SL, Hess P, Qiu C, Buchmann S, Scherz M, Weller T, Fischli W, Clozel M, Jenck F.

Nat Med. 2007 Feb;13(2):150-5. Epub 2007 Jan 28.

PMID:
17259994
14.

Controlled cortical impact traumatic brain injury acutely disrupts wakefulness and extracellular orexin dynamics as determined by intracerebral microdialysis in mice.

Willie JT, Lim MM, Bennett RE, Azarion AA, Schwetye KE, Brody DL.

J Neurotrauma. 2012 Jul 1;29(10):1908-21. doi: 10.1089/neu.2012.2404.

15.

Selective loss of GABA(B) receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture.

Matsuki T, Nomiyama M, Takahira H, Hirashima N, Kunita S, Takahashi S, Yagami K, Kilduff TS, Bettler B, Yanagisawa M, Sakurai T.

Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4459-64. doi: 10.1073/pnas.0811126106. Epub 2009 Feb 25. Erratum in: Proc Natl Acad Sci U S A. 2009 May 26;106(21):8790.

16.

Brain orexins and wake regulation in rats exposed to maternal deprivation.

Feng P, Vurbic D, Wu Z, Strohl KP.

Brain Res. 2007 Jun 18;1154:163-72. Epub 2007 Mar 31.

PMID:
17466285
17.

The effect of clomipramine on wake/sleep and orexinergic expression in rats.

Feng P, Hu Y, Li D, Vurbic D, Fan H, Wang S, Strohl KP.

J Psychopharmacol. 2009 Jul;23(5):559-66. doi: 10.1177/0269881108089606. Epub 2008 Jun 18.

18.

Dynein light chain Tctex-type 1 modulates orexin signaling through its interaction with orexin 1 receptor.

Duguay D, Bélanger-Nelson E, Mongrain V, Beben A, Khatchadourian A, Cermakian N.

PLoS One. 2011;6(10):e26430. doi: 10.1371/journal.pone.0026430. Epub 2011 Oct 20.

19.

Neuronal activity regulates the regional vulnerability to amyloid-β deposition.

Bero AW, Yan P, Roh JH, Cirrito JR, Stewart FR, Raichle ME, Lee JM, Holtzman DM.

Nat Neurosci. 2011 Jun;14(6):750-6. doi: 10.1038/nn.2801. Epub 2011 May 1.

20.

Cholecystokinin activates orexin/hypocretin neurons through the cholecystokinin A receptor.

Tsujino N, Yamanaka A, Ichiki K, Muraki Y, Kilduff TS, Yagami K, Takahashi S, Goto K, Sakurai T.

J Neurosci. 2005 Aug 10;25(32):7459-69.

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