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Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity.

Zhang Y, Ikeno Y, Qi W, Chaudhuri A, Li Y, Bokov A, Thorpe SR, Baynes JW, Epstein C, Richardson A, Van Remmen H.

J Gerontol A Biol Sci Med Sci. 2009 Dec;64(12):1212-20. doi: 10.1093/gerona/glp132. Epub 2009 Sep 23.


Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging.

Van Remmen H, Ikeno Y, Hamilton M, Pahlavani M, Wolf N, Thorpe SR, Alderson NL, Baynes JW, Epstein CJ, Huang TT, Nelson J, Strong R, Richardson A.

Physiol Genomics. 2003 Dec 16;16(1):29-37.


Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress.

Van Remmen H, Qi W, Sabia M, Freeman G, Estlack L, Yang H, Mao Guo Z, Huang TT, Strong R, Lee S, Epstein CJ, Richardson A.

Free Radic Biol Med. 2004 Jun 15;36(12):1625-34.


Alterations in mitochondrial function, hydrogen peroxide release and oxidative damage in mouse hind-limb skeletal muscle during aging.

Mansouri A, Muller FL, Liu Y, Ng R, Faulkner J, Hamilton M, Richardson A, Huang TT, Epstein CJ, Van Remmen H.

Mech Ageing Dev. 2006 Mar;127(3):298-306. Epub 2006 Jan 6.


Sod2 haploinsufficiency does not accelerate aging of telomere dysfunctional mice.

Guachalla LM, Ju Z, Koziel R, von Figura G, Song Z, Fusser M, Epe B, Jansen-Durr P, Rudolph KL.

Aging (Albany NY). 2009 Mar 5;1(3):303-15.


Reduced mitochondrial ROS, enhanced antioxidant defense, and distinct age-related changes in oxidative damage in muscles of long-lived Peromyscus leucopus.

Shi Y, Pulliam DA, Liu Y, Hamilton RT, Jernigan AL, Bhattacharya A, Sloane LB, Qi W, Chaudhuri A, Buffenstein R, Ungvari Z, Austad SN, Van Remmen H.

Am J Physiol Regul Integr Comp Physiol. 2013 Mar 1;304(5):R343-55. doi: 10.1152/ajpregu.00139.2012. Epub 2013 Jan 16.


Glutathione peroxidase deficiency exacerbates ischemia-reperfusion injury in male but not female myocardium: insights into antioxidant compensatory mechanisms.

Lim CC, Bryan NS, Jain M, Garcia-Saura MF, Fernandez BO, Sawyer DB, Handy DE, Loscalzo J, Feelisch M, Liao R.

Am J Physiol Heart Circ Physiol. 2009 Dec;297(6):H2144-53. doi: 10.1152/ajpheart.00673.2009. Epub 2009 Oct 2.


Revisiting an age-old question regarding oxidative stress.

Edrey YH, Salmon AB.

Free Radic Biol Med. 2014 Jun;71:368-78. doi: 10.1016/j.freeradbiomed.2014.03.038. Epub 2014 Apr 4. Review.


Genetic modification of the manganese superoxide dismutase/glutathione peroxidase 1 pathway influences intracellular ROS generation in quiescent, but not contracting, skeletal muscle cells.

Vasilaki A, Csete M, Pye D, Lee S, Palomero J, McArdle F, Van Remmen H, Richardson A, McArdle A, Faulkner JA, Jackson MJ.

Free Radic Biol Med. 2006 Dec 1;41(11):1719-25. Epub 2006 Sep 15.


Gender differences in free radical homeostasis during aging: shorter-lived female C57BL6 mice have increased oxidative stress.

Ali SS, Xiong C, Lucero J, Behrens MM, Dugan LL, Quick KL.

Aging Cell. 2006 Dec;5(6):565-74.


Knockout of SOD1 promotes conversion of selenocysteine to dehydroalanine in murine hepatic GPX1 protein.

Wang SK, Weaver JD, Zhang S, Lei XG.

Free Radic Biol Med. 2011 Jul 1;51(1):197-204. doi: 10.1016/j.freeradbiomed.2011.03.018. Epub 2011 Mar 17.


Overexpression of Mn superoxide dismutase does not increase life span in mice.

Jang YC, Pérez VI, Song W, Lustgarten MS, Salmon AB, Mele J, Qi W, Liu Y, Liang H, Chaudhuri A, Ikeno Y, Epstein CJ, Van Remmen H, Richardson A.

J Gerontol A Biol Sci Med Sci. 2009 Nov;64(11):1114-25. doi: 10.1093/gerona/glp100. Epub 2009 Jul 24.


Glutathione peroxidase 1 activity dictates the sensitivity of glioblastoma cells to oxidative stress.

Dokic I, Hartmann C, Herold-Mende C, Régnier-Vigouroux A.

Glia. 2012 Nov;60(11):1785-800. doi: 10.1002/glia.22397. Epub 2012 Aug 1.


Retinal light damage: structural and functional effects of the antioxidant glutathione peroxidase-1.

Gosbell AD, Stefanovic N, Scurr LL, Pete J, Kola I, Favilla I, de Haan JB.

Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2613-22.


Characterization of the antioxidant status of the heterozygous manganese superoxide dismutase knockout mouse.

Van Remmen H, Salvador C, Yang H, Huang TT, Epstein CJ, Richardson A.

Arch Biochem Biophys. 1999 Mar 1;363(1):91-7.


Mitochondrial oxidative stress in mice lacking the glutathione peroxidase-1 gene.

Esposito LA, Kokoszka JE, Waymire KG, Cottrell B, MacGregor GR, Wallace DC.

Free Radic Biol Med. 2000 Mar 1;28(5):754-66.


Increased oxidative damage is correlated to altered mitochondrial function in heterozygous manganese superoxide dismutase knockout mice.

Williams MD, Van Remmen H, Conrad CC, Huang TT, Epstein CJ, Richardson A.

J Biol Chem. 1998 Oct 23;273(43):28510-5.


Mice deficient in Cu,Zn-superoxide dismutase are resistant to acetaminophen toxicity.

Lei XG, Zhu JH, McClung JP, Aregullin M, Roneker CA.

Biochem J. 2006 Nov 1;399(3):455-61.


Mitochondrial oxidative stress and epilepsy in SOD2 deficient mice: attenuation by a lipophilic metalloporphyrin.

Liang LP, Waldbaum S, Rowley S, Huang TT, Day BJ, Patel M.

Neurobiol Dis. 2012 Mar;45(3):1068-76. doi: 10.1016/j.nbd.2011.12.025. Epub 2011 Dec 16.


Glutathione peroxidase-1 gene knockout on body antioxidant defense in mice.

Lei XG.

Biofactors. 2001;14(1-4):93-9. Review.


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