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Cell-type-specific tyrosine phosphorylation of the herpes simplex virus tegument protein VP11/12 encoded by gene UL46.

Zahariadis G, Wagner MJ, Doepker RC, Maciejko JM, Crider CM, Jerome KR, Smiley JR.

J Virol. 2008 Jul;82(13):6098-108. doi: 10.1128/JVI.02121-07. Epub 2008 Apr 16.


Herpes simplex virus protein kinases US3 and UL13 modulate VP11/12 phosphorylation, virion packaging, and phosphatidylinositol 3-kinase/Akt signaling activity.

Eaton HE, Saffran HA, Wu FW, Quach K, Smiley JR.

J Virol. 2014 Jul;88(13):7379-88. doi: 10.1128/JVI.00712-14. Epub 2014 Apr 16.


Role of herpes simplex virus VP11/12 tyrosine-based motifs in binding and activation of the Src family kinase Lck and recruitment of p85, Grb2, and Shc.

Strunk U, Saffran HA, Wu FW, Smiley JR.

J Virol. 2013 Oct;87(20):11276-86. doi: 10.1128/JVI.01702-13. Epub 2013 Aug 14.


Herpes simplex virus requires VP11/12 to activate Src family kinase-phosphoinositide 3-kinase-Akt signaling.

Wagner MJ, Smiley JR.

J Virol. 2011 Mar;85(6):2803-12. doi: 10.1128/JVI.01877-10. Epub 2011 Jan 12.


Growth transformation of human T cells by herpesvirus saimiri requires multiple Tip-Lck interaction motifs.

Heck E, Friedrich U, Gack MU, Lengenfelder D, Schmidt M, Müller-Fleckenstein I, Fleckenstein B, Ensser A, Biesinger B.

J Virol. 2006 Oct;80(20):9934-42.


Herpes simplex virus 1 infection of T cells causes VP11/12-dependent phosphorylation and degradation of the cellular protein Dok-2.

Lahmidi S, Strunk U, Smiley JR, Pearson A, Duplay P.

Virology. 2017 Nov;511:66-73. doi: 10.1016/j.virol.2017.08.018. Epub 2017 Aug 23.


Activation of the Lck tyrosine protein kinase by the Herpesvirus saimiri tip protein involves two binding interactions.

Hartley DA, Amdjadi K, Hurley TR, Lund TC, Medveczky PG, Sefton BM.

Virology. 2000 Oct 25;276(2):339-48.


Herpes simplex virus 1 protein kinase Us3 phosphorylates viral envelope glycoprotein B and regulates its expression on the cell surface.

Kato A, Arii J, Shiratori I, Akashi H, Arase H, Kawaguchi Y.

J Virol. 2009 Jan;83(1):250-61. doi: 10.1128/JVI.01451-08. Epub 2008 Oct 22.


Modulation of Lck function through multisite docking to T cell-specific adapter protein.

Granum S, Andersen TC, Sørlie M, Jørgensen M, Koll L, Berge T, Lea T, Fleckenstein B, Spurkland A, Sundvold-Gjerstad V.

J Biol Chem. 2008 Aug 8;283(32):21909-19. doi: 10.1074/jbc.M800871200. Epub 2008 Jun 9.


Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation.

Yamaguchi H, Hendrickson WA.

Nature. 1996 Dec 5;384(6608):484-9.


Regulation of the catalytic activity of herpes simplex virus 1 protein kinase Us3 by autophosphorylation and its role in pathogenesis.

Sagou K, Imai T, Sagara H, Uema M, Kawaguchi Y.

J Virol. 2009 Jun;83(11):5773-83. doi: 10.1128/JVI.00103-09. Epub 2009 Mar 18.


Role of Herpes simplex virus 1 VP11/12 tyrosine-based binding motifs for Src family kinases, p85, Grb2 and Shc in activation of the phosphoinositide 3-kinase-Akt pathway.

Strunk U, Ramos DG, Saffran HA, Smiley JR.

Virology. 2016 Nov;498:31-35. doi: 10.1016/j.virol.2016.08.007. Epub 2016 Aug 17.


Herpes simplex virus entry is associated with tyrosine phosphorylation of cellular proteins.

Qie L, Marcellino D, Herold BC.

Virology. 1999 Apr 10;256(2):220-7.


CD45-associated kinase activity requires lck but not T cell receptor expression in the Jurkat T cell line.

Koretzky GA, Kohmetscher M, Ross S.

J Biol Chem. 1993 Apr 25;268(12):8958-64.


Properties of tripartite chimeras between Src and Lck.

Kashishian A, MacAuley A, Cooper JA.

Oncogene. 1990 Oct;5(10):1463-70.


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