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Items: 1 to 20 of 99


Effect of anaplerotic fluxes and amino acid availability on hepatic lipoapoptosis.

Noguchi Y, Young JD, Aleman JO, Hansen ME, Kelleher JK, Stephanopoulos G.

J Biol Chem. 2009 Nov 27;284(48):33425-36. doi: 10.1074/jbc.M109.049478. Epub 2009 Sep 16.


Tracking cellular metabolomics in lipoapoptosis- and steatosis-developing liver cells.

Noguchi Y, Young JD, Aleman JO, Hansen ME, Kelleher JK, Stephanopoulos G.

Mol Biosyst. 2011 May;7(5):1409-19. doi: 10.1039/c0mb00309c. Epub 2011 Feb 16.


Palmitate-induced activation of mitochondrial metabolism promotes oxidative stress and apoptosis in H4IIEC3 rat hepatocytes.

Egnatchik RA, Leamy AK, Noguchi Y, Shiota M, Young JD.

Metabolism. 2014 Feb;63(2):283-95. doi: 10.1016/j.metabol.2013.10.009. Epub 2013 Oct 24.


Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria.

Nakamura S, Takamura T, Matsuzawa-Nagata N, Takayama H, Misu H, Noda H, Nabemoto S, Kurita S, Ota T, Ando H, Miyamoto K, Kaneko S.

J Biol Chem. 2009 May 29;284(22):14809-18. doi: 10.1074/jbc.M901488200. Epub 2009 Mar 30.


ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to palmitate overload.

Egnatchik RA, Leamy AK, Jacobson DA, Shiota M, Young JD.

Mol Metab. 2014 May 22;3(5):544-53. doi: 10.1016/j.molmet.2014.05.004. eCollection 2014 Aug.


Fatty acid-induced oxidation and triglyceride formation is higher in insulin-producing MIN6 cells exposed to oleate compared to palmitate.

Thörn K, Bergsten P.

J Cell Biochem. 2010 Oct 1;111(2):497-507. doi: 10.1002/jcb.22734.


Oleate rescues INS-1E β-cells from palmitate-induced apoptosis by preventing activation of the unfolded protein response.

Sommerweiss D, Gorski T, Richter S, Garten A, Kiess W.

Biochem Biophys Res Commun. 2013 Nov 29;441(4):770-6. doi: 10.1016/j.bbrc.2013.10.130. Epub 2013 Nov 1.


Oleate protects macrophages from palmitate-induced apoptosis through the downregulation of CD36 expression.

Kim DH, Cho YM, Lee KH, Jeong SW, Kwon OJ.

Biochem Biophys Res Commun. 2017 Jul 1;488(3):477-482. doi: 10.1016/j.bbrc.2017.05.066. Epub 2017 May 15.


Fatty acid-induced defects in insulin signalling, in myotubes derived from children, are related to ceramide production from palmitate rather than the accumulation of intramyocellular lipid.

Sabin MA, Stewart CE, Crowne EC, Turner SJ, Hunt LP, Welsh GI, Grohmann MJ, Holly JM, Shield JP.

J Cell Physiol. 2007 Apr;211(1):244-52.


Phosphorylation of caveolin-1 on tyrosine-14 induced by ROS enhances palmitate-induced death of beta-pancreatic cells.

Wehinger S, Ortiz R, Díaz MI, Aguirre A, Valenzuela M, Llanos P, Mc Master C, Leyton L, Quest AF.

Biochim Biophys Acta. 2015 May;1852(5):693-708. doi: 10.1016/j.bbadis.2014.12.021. Epub 2015 Jan 5.


Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress.

Yuzefovych L, Wilson G, Rachek L.

Am J Physiol Endocrinol Metab. 2010 Dec;299(6):E1096-105. doi: 10.1152/ajpendo.00238.2010. Epub 2010 Sep 28.


α-Lactalbumin-oleic acid complex kills tumor cells by inducing excess energy metabolism but inhibiting mRNA expression of the related enzymes.

Fang B, Zhang M, Ge KS, Xing HZ, Ren FZ.

J Dairy Sci. 2018 Jun;101(6):4853-4863. doi: 10.3168/jds.2017-13731. Epub 2018 Mar 15.


Silybin counteracts lipid excess and oxidative stress in cultured steatotic hepatic cells.

Vecchione G, Grasselli E, Voci A, Baldini F, Grattagliano I, Wang DQ, Portincasa P, Vergani L.

World J Gastroenterol. 2016 Jul 14;22(26):6016-26. doi: 10.3748/wjg.v22.i26.6016.


Metformin influences cardiomyocyte cell death by pathways that are dependent and independent of caspase-3.

An D, Kewalramani G, Chan JK, Qi D, Ghosh S, Pulinilkunnil T, Abrahani A, Innis SM, Rodrigues B.

Diabetologia. 2006 Sep;49(9):2174-84. Epub 2006 Jul 26.


Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulin resistance.

Turpin SM, Lancaster GI, Darby I, Febbraio MA, Watt MJ.

Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1341-50. Epub 2006 Jul 18.


Increased mitochondrial fatty acid oxidation is sufficient to protect skeletal muscle cells from palmitate-induced apoptosis.

Henique C, Mansouri A, Fumey G, Lenoir V, Girard J, Bouillaud F, Prip-Buus C, Cohen I.

J Biol Chem. 2010 Nov 19;285(47):36818-27. doi: 10.1074/jbc.M110.170431. Epub 2010 Sep 12.


Lipotoxic Palmitate Impairs the Rate of β-Oxidation and Citric Acid Cycle Flux in Rat Neonatal Cardiomyocytes.

Haffar T, Akoumi A, Bousette N.

Cell Physiol Biochem. 2016;40(5):969-981. Epub 2016 Dec 7.


A human hepatocellular in vitro model to investigate steatosis.

Gómez-Lechón MJ, Donato MT, Martínez-Romero A, Jiménez N, Castell JV, O'Connor JE.

Chem Biol Interact. 2007 Jan 30;165(2):106-16. Epub 2006 Nov 23.


Glutamate-oxaloacetate transaminase activity promotes palmitate lipotoxicity in rat hepatocytes by enhancing anaplerosis and citric acid cycle flux.

Egnatchik RA, Leamy AK, Sacco SA, Cheah YE, Shiota M, Young JD.

J Biol Chem. 2018 Dec 18. pii: jbc.RA118.004869. doi: 10.1074/jbc.RA118.004869. [Epub ahead of print]


Palmitate-induced apoptosis in neonatal cardiomyocytes is not dependent on the generation of ROS.

Hickson-Bick DL, Sparagna GC, Buja LM, McMillin JB.

Am J Physiol Heart Circ Physiol. 2002 Feb;282(2):H656-64.

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