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Structural and functional insights into the roles of the Mms21 subunit of the Smc5/6 complex.

Duan X, Sarangi P, Liu X, Rangi GK, Zhao X, Ye H.

Mol Cell. 2009 Sep 11;35(5):657-68. doi: 10.1016/j.molcel.2009.06.032.


ATPase-dependent control of the Mms21 SUMO ligase during DNA repair.

Bermúdez-López M, Pociño-Merino I, Sánchez H, Bueno A, Guasch C, Almedawar S, Bru-Virgili S, Garí E, Wyman C, Reverter D, Colomina N, Torres-Rosell J.

PLoS Biol. 2015 Mar 12;13(3):e1002089. doi: 10.1371/journal.pbio.1002089. eCollection 2015 Mar.


Interaction mapping between Saccharomyces cerevisiae Smc5 and SUMO E3 ligase Mms21.

Duan X, Holmes WB, Ye H.

Biochemistry. 2011 Nov 22;50(46):10182-8. doi: 10.1021/bi201376e. Epub 2011 Oct 31.


Purification, crystallization and preliminary X-ray crystallographic studies of the complex between Smc5 and the SUMO E3 ligase Mms21.

Duan X, Ye H.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Aug 1;65(Pt 8):849-52. doi: 10.1107/S1744309109027900. Epub 2009 Jul 30.


A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization.

Zhao X, Blobel G.

Proc Natl Acad Sci U S A. 2005 Mar 29;102(13):4777-82. Epub 2005 Feb 28. Erratum in: Proc Natl Acad Sci U S A. 2005 Jun 21;102(25):9086.


Sumoylation and the structural maintenance of chromosomes (Smc) 5/6 complex slow senescence through recombination intermediate resolution.

Chavez A, George V, Agrawal V, Johnson FB.

J Biol Chem. 2010 Apr 16;285(16):11922-30. doi: 10.1074/jbc.M109.041277. Epub 2010 Feb 16.


Allelism of Saccharomyces cerevisiae gene PSO10, involved in error-prone repair of psoralen-induced DNA damage, with SUMO ligase-encoding MMS21.

Hoch NC, Santos RS, Rosa RM, Machado RM, Saffi J, Brendel M, Henriques JA.

Curr Genet. 2008 Jun;53(6):361-71. doi: 10.1007/s00294-008-0192-z. Epub 2008 Apr 24.


Small ubiquitin-related modifier ligase activity of Mms21 is required for maintenance of chromosome integrity during the unperturbed mitotic cell division cycle in Saccharomyces cerevisiae.

Rai R, Varma SP, Shinde N, Ghosh S, Kumaran SP, Skariah G, Laloraya S.

J Biol Chem. 2011 Apr 22;286(16):14516-30. doi: 10.1074/jbc.M110.157149. Epub 2011 Feb 15.


Human MMS21/NSE2 is a SUMO ligase required for DNA repair.

Potts PR, Yu H.

Mol Cell Biol. 2005 Aug;25(16):7021-32.


The Saccharomyces cerevisiae Esc2 and Smc5-6 proteins promote sister chromatid junction-mediated intra-S repair.

Sollier J, Driscoll R, Castellucci F, Foiani M, Jackson SP, Branzei D.

Mol Biol Cell. 2009 Mar;20(6):1671-82. doi: 10.1091/mbc.E08-08-0875. Epub 2009 Jan 21.


During replication stress, non-SMC element 5 (NSE5) is required for Smc5/6 protein complex functionality at stalled forks.

Bustard DE, Menolfi D, Jeppsson K, Ball LG, Dewey SC, Shirahige K, Sjögren C, Branzei D, Cobb JA.

J Biol Chem. 2012 Mar 30;287(14):11374-83. doi: 10.1074/jbc.M111.336263. Epub 2012 Feb 2.


Smc5p promotes faithful chromosome transmission and DNA repair in Saccharomyces cerevisiae.

Cost GJ, Cozzarelli NR.

Genetics. 2006 Apr;172(4):2185-200. Epub 2006 Feb 1.


Requirement of Nse1, a subunit of the Smc5-Smc6 complex, for Rad52-dependent postreplication repair of UV-damaged DNA in Saccharomyces cerevisiae.

Santa Maria SR, Gangavarapu V, Johnson RE, Prakash L, Prakash S.

Mol Cell Biol. 2007 Dec;27(23):8409-18. Epub 2007 Oct 8.


Mec1-dependent phosphorylation of Mms21 modulates its SUMO ligase activity.

Carlborg KK, Kanno T, Carter SD, Sjögren C.

DNA Repair (Amst). 2015 Apr;28:83-92. doi: 10.1016/j.dnarep.2015.01.006. Epub 2015 Jan 30.


Mms21 SUMO Ligase Activity Promotes Nucleolar Function in Saccharomyces cerevisiae.

Kim DH, Harris B, Wang F, Seidel C, McCroskey S, Gerton JL.

Genetics. 2016 Oct;204(2):645-658. Epub 2016 Aug 10.


Architecture of the Smc5/6 Complex of Saccharomyces cerevisiae Reveals a Unique Interaction between the Nse5-6 Subcomplex and the Hinge Regions of Smc5 and Smc6.

Duan X, Yang Y, Chen YH, Arenz J, Rangi GK, Zhao X, Ye H.

J Biol Chem. 2009 Mar 27;284(13):8507-15. doi: 10.1074/jbc.M809139200. Epub 2009 Jan 13.


Structure of the Siz/PIAS SUMO E3 ligase Siz1 and determinants required for SUMO modification of PCNA.

Yunus AA, Lima CD.

Mol Cell. 2009 Sep 11;35(5):669-82. doi: 10.1016/j.molcel.2009.07.013.


Rtt107 is required for recruitment of the SMC5/6 complex to DNA double strand breaks.

Leung GP, Lee L, Schmidt TI, Shirahige K, Kobor MS.

J Biol Chem. 2011 Jul 22;286(29):26250-7. doi: 10.1074/jbc.M111.235200. Epub 2011 Jun 3.


Smc5/6-Mms21 prevents and eliminates inappropriate recombination intermediates in meiosis.

Xaver M, Huang L, Chen D, Klein F.

PLoS Genet. 2013;9(12):e1004067. doi: 10.1371/journal.pgen.1004067. Epub 2013 Dec 26.

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