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A luminal epithelial stem cell that is a cell of origin for prostate cancer.

Wang X, Kruithof-de Julio M, Economides KD, Walker D, Yu H, Halili MV, Hu YP, Price SM, Abate-Shen C, Shen MM.

Nature. 2009 Sep 24;461(7263):495-500. doi: 10.1038/nature08361. Epub 2009 Sep 9.


Luminal cells are favored as the cell of origin for prostate cancer.

Wang ZA, Toivanen R, Bergren SK, Chambon P, Shen MM.

Cell Rep. 2014 Sep 11;8(5):1339-46. doi: 10.1016/j.celrep.2014.08.002. Epub 2014 Aug 28.


Conditionally ablated Pten in prostate basal cells promotes basal-to-luminal differentiation and causes invasive prostate cancer in mice.

Lu TL, Huang YF, You LR, Chao NC, Su FY, Chang JL, Chen CM.

Am J Pathol. 2013 Mar;182(3):975-91. doi: 10.1016/j.ajpath.2012.11.025. Epub 2013 Jan 9.


Progenitor cells for the prostate epithelium: roles in development, regeneration, and cancer.

Shen MM, Wang X, Economides KD, Walker D, Abate-Shen C.

Cold Spring Harb Symp Quant Biol. 2008;73:529-38. doi: 10.1101/sqb.2008.73.050. Epub 2009 Jan 15. Review.


Stem-like cells with luminal progenitor phenotype survive castration in human prostate cancer.

Germann M, Wetterwald A, Guzmán-Ramirez N, van der Pluijm G, Culig Z, Cecchini MG, Williams ED, Thalmann GN.

Stem Cells. 2012 Jun;30(6):1076-86. doi: 10.1002/stem.1087.


Emergence of androgen independence at early stages of prostate cancer progression in Nkx3.1; Pten mice.

Gao H, Ouyang X, Banach-Petrosky WA, Shen MM, Abate-Shen C.

Cancer Res. 2006 Aug 15;66(16):7929-33.


Single luminal epithelial progenitors can generate prostate organoids in culture.

Chua CW, Shibata M, Lei M, Toivanen R, Barlow LJ, Bergren SK, Badani KK, McKiernan JM, Benson MC, Hibshoosh H, Shen MM.

Nat Cell Biol. 2014 Oct;16(10):951-61, 1-4. doi: 10.1038/ncb3047. Epub 2014 Sep 21.


MYC overexpression induces prostatic intraepithelial neoplasia and loss of Nkx3.1 in mouse luminal epithelial cells.

Iwata T, Schultz D, Hicks J, Hubbard GK, Mutton LN, Lotan TL, Bethel C, Lotz MT, Yegnasubramanian S, Nelson WG, Dang CV, Xu M, Anele U, Koh CM, Bieberich CJ, De Marzo AM.

PLoS One. 2010 Feb 25;5(2):e9427. doi: 10.1371/journal.pone.0009427.


Prolonged exposure to reduced levels of androgen accelerates prostate cancer progression in Nkx3.1; Pten mutant mice.

Banach-Petrosky W, Jessen WJ, Ouyang X, Gao H, Rao J, Quinn J, Aronow BJ, Abate-Shen C.

Cancer Res. 2007 Oct 1;67(19):9089-96.


Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay.

Park JW, Lee JK, Phillips JW, Huang P, Cheng D, Huang J, Witte ON.

Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4482-7. doi: 10.1073/pnas.1603645113. Epub 2016 Apr 4.


Loss of Nkx3.1 leads to the activation of discrete downstream target genes during prostate tumorigenesis.

Song H, Zhang B, Watson MA, Humphrey PA, Lim H, Milbrandt J.

Oncogene. 2009 Sep 17;28(37):3307-19. doi: 10.1038/onc.2009.181. Epub 2009 Jul 13.


Self-renewing Pten-/- TP53-/- protospheres produce metastatic adenocarcinoma cell lines with multipotent progenitor activity.

Abou-Kheir W, Hynes PG, Martin P, Yin JJ, Liu YN, Seng V, Lake R, Spurrier J, Kelly K.

PLoS One. 2011;6(10):e26112. doi: 10.1371/journal.pone.0026112. Epub 2011 Oct 11.


Characterizing the contribution of stem/progenitor cells to tumorigenesis in the Pten-/-TP53-/- prostate cancer model.

Abou-Kheir WG, Hynes PG, Martin PL, Pierce R, Kelly K.

Stem Cells. 2010 Dec;28(12):2129-40. doi: 10.1002/stem.538.


Lineage analysis of basal epithelial cells reveals their unexpected plasticity and supports a cell-of-origin model for prostate cancer heterogeneity.

Wang ZA, Mitrofanova A, Bergren SK, Abate-Shen C, Cardiff RD, Califano A, Shen MM.

Nat Cell Biol. 2013 Mar;15(3):274-83. doi: 10.1038/ncb2697. Epub 2013 Feb 24.


Accumulating progenitor cells in the luminal epithelial cell layer are candidate tumor initiating cells in a Pten knockout mouse prostate cancer model.

Korsten H, Ziel-van der Made A, Ma X, van der Kwast T, Trapman J.

PLoS One. 2009 May 22;4(5):e5662. doi: 10.1371/journal.pone.0005662.


Nkx3.1 and Myc crossregulate shared target genes in mouse and human prostate tumorigenesis.

Anderson PD, McKissic SA, Logan M, Roh M, Franco OE, Wang J, Doubinskaia I, van der Meer R, Hayward SW, Eischen CM, Eltoum IE, Abdulkadir SA.

J Clin Invest. 2012 May;122(5):1907-19. doi: 10.1172/JCI58540. Epub 2012 Apr 9.


Androgen regulation of the prostatic tumour suppressor NKX3.1 is mediated by its 3' untranslated region.

Thomas MA, Preece DM, Bentel JM.

Biochem J. 2010 Jan 15;425(3):575-83. doi: 10.1042/BJ20091109.


Id4 deficiency attenuates prostate development and promotes PIN-like lesions by regulating androgen receptor activity and expression of NKX3.1 and PTEN.

Sharma P, Knowell AE, Chinaranagari S, Komaragiri S, Nagappan P, Patel D, Havrda MC, Chaudhary J.

Mol Cancer. 2013 Jun 21;12:67. doi: 10.1186/1476-4598-12-67.


Bmi1 marks distinct castration-resistant luminal progenitor cells competent for prostate regeneration and tumour initiation.

Yoo YA, Roh M, Naseem AF, Lysy B, Desouki MM, Unno K, Abdulkadir SA.

Nat Commun. 2016 Oct 5;7:12943. doi: 10.1038/ncomms12943.


Differential requirements for β-catenin in murine prostate cancer originating from basal versus luminal cells.

Lu TL, Chen CM.

J Pathol. 2015 Jul;236(3):290-301. doi: 10.1002/path.4521. Epub 2015 Apr 8.


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