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Items: 1 to 20 of 104


Identification of a novel, widespread, and functionally important PCNA-binding motif.

Gilljam KM, Feyzi E, Aas PA, Sousa MM, Müller R, Vågbø CB, Catterall TC, Liabakk NB, Slupphaug G, Drabløs F, Krokan HE, Otterlei M.

J Cell Biol. 2009 Sep 7;186(5):645-54. doi: 10.1083/jcb.200903138.


Nucleotide excision repair is associated with the replisome and its efficiency depends on a direct interaction between XPA and PCNA.

Gilljam KM, Müller R, Liabakk NB, Otterlei M.

PLoS One. 2012;7(11):e49199. doi: 10.1371/journal.pone.0049199. Epub 2012 Nov 13.


The interaction between ALKBH2 DNA repair enzyme and PCNA is direct, mediated by the hydrophobic pocket of PCNA and perturbed in naturally-occurring ALKBH2 variants.

Fu D, Samson LD, Hübscher U, van Loon B.

DNA Repair (Amst). 2015 Nov;35:13-8. doi: 10.1016/j.dnarep.2015.09.008. Epub 2015 Sep 14.


PCNA-interacting peptides reduce Akt phosphorylation and TLR-mediated cytokine secretion suggesting a role of PCNA in cellular signaling.

Olaisen C, Müller R, Nedal A, Otterlei M.

Cell Signal. 2015 Jul;27(7):1478-87. doi: 10.1016/j.cellsig.2015.03.009. Epub 2015 Mar 20.


Targeting proliferating cell nuclear antigen and its protein interactions induces apoptosis in multiple myeloma cells.

Müller R, Misund K, Holien T, Bachke S, Gilljam KM, Våtsveen TK, Rø TB, Bellacchio E, Sundan A, Otterlei M.

PLoS One. 2013 Jul 31;8(7):e70430. doi: 10.1371/journal.pone.0070430. Print 2013.


Bi-directional routing of DNA mismatch repair protein human exonuclease 1 to replication foci and DNA double strand breaks.

Liberti SE, Andersen SD, Wang J, May A, Miron S, Perderiset M, Keijzers G, Nielsen FC, Charbonnier JB, Bohr VA, Rasmussen LJ.

DNA Repair (Amst). 2011 Jan 2;10(1):73-86. doi: 10.1016/j.dnarep.2010.09.023. Epub 2010 Oct 20.


Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA.

Westbye MP, Feyzi E, Aas PA, Vågbø CB, Talstad VA, Kavli B, Hagen L, Sundheim O, Akbari M, Liabakk NB, Slupphaug G, Otterlei M, Krokan HE.

J Biol Chem. 2008 Sep 5;283(36):25046-56. doi: 10.1074/jbc.M803776200. Epub 2008 Jul 3.


The PCNA interaction protein box sequence in Rad54 is an integral part of its ATPase domain and is required for efficient DNA repair and recombination.

Burgess RC, Sebesta M, Sisakova A, Marini VP, Lisby M, Damborsky J, Klein H, Rothstein R, Krejci L.

PLoS One. 2013 Dec 20;8(12):e82630. doi: 10.1371/journal.pone.0082630. eCollection 2013. Erratum in: PLoS One. 2014;9(6):e101095.


Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta.

Ducoux M, Urbach S, Baldacci G, Hübscher U, Koundrioukoff S, Christensen J, Hughes P.

J Biol Chem. 2001 Dec 28;276(52):49258-66. Epub 2001 Oct 10.


Frequent down-regulation of hABH2 in gastric cancer and its involvement in growth of cancer cells.

Gao W, Li L, Xu P, Fang J, Xiao S, Chen S.

J Gastroenterol Hepatol. 2011 Mar;26(3):577-84. doi: 10.1111/j.1440-1746.2010.06531.x.


A site-selective, irreversible inhibitor of the DNA replication auxiliary factor proliferating cell nuclear antigen (PCNA).

Evison BJ, Actis ML, Wu SZ, Shao Y, Heath RJ, Yang L, Fujii N.

Bioorg Med Chem. 2014 Nov 15;22(22):6333-43. doi: 10.1016/j.bmc.2014.09.058. Epub 2014 Oct 8.


Saccharomyces cerevisiae RRM3, a 5' to 3' DNA helicase, physically interacts with proliferating cell nuclear antigen.

Schmidt KH, Derry KL, Kolodner RD.

J Biol Chem. 2002 Nov 22;277(47):45331-7. Epub 2002 Sep 17.


MutLalpha and proliferating cell nuclear antigen share binding sites on MutSbeta.

Iyer RR, Pluciennik A, Genschel J, Tsai MS, Beese LS, Modrich P.

J Biol Chem. 2010 Apr 9;285(15):11730-9. doi: 10.1074/jbc.M110.104125. Epub 2010 Feb 12.


Binding to PCNA in Euryarchaeal DNA Replication requires two PIP motifs for DNA polymerase D and one PIP motif for DNA polymerase B.

Castrec B, Rouillon C, Henneke G, Flament D, Querellou J, Raffin JP.

J Mol Biol. 2009 Nov 27;394(2):209-18. doi: 10.1016/j.jmb.2009.09.044. Epub 2009 Sep 23.


A novel archaeal DNA repair factor that acts with the UvrABC system to repair mitomycin C-induced DNA damage in a PCNA-dependent manner.

Giroux X, MacNeill SA.

Mol Microbiol. 2016 Jan;99(1):1-14. doi: 10.1111/mmi.13210. Epub 2015 Oct 14.


Pediatric brain tumors: mutations of two dioxygenases (hABH2 and hABH3) that directly repair alkylation damage.

Cetica V, Genitori L, Giunti L, Sanzo M, Bernini G, Massimino M, Sardi I.

J Neurooncol. 2009 Sep;94(2):195-201. doi: 10.1007/s11060-009-9837-0. Epub 2009 Mar 17.


hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci.

Kleczkowska HE, Marra G, Lettieri T, Jiricny J.

Genes Dev. 2001 Mar 15;15(6):724-36.


14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif.

Andersen SD, Keijzers G, Rampakakis E, Engels K, Luhn P, El-Shemerly M, Nielsen FC, Du Y, May A, Bohr VA, Ferrari S, Zannis-Hadjopoulos M, Fu H, Rasmussen LJ.

DNA Repair (Amst). 2012 Mar 1;11(3):267-77. doi: 10.1016/j.dnarep.2011.11.007. Epub 2012 Jan 4.


AlkB demethylases flip out in different ways.

Sundheim O, Talstad VA, Vågbø CB, Slupphaug G, Krokan HE.

DNA Repair (Amst). 2008 Nov 1;7(11):1916-23. doi: 10.1016/j.dnarep.2008.07.015. Epub 2008 Sep 6. Review.


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