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Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunction.

Chen ML, Logan TD, Hochberg ML, Shelat SG, Yu X, Wilding GE, Tan W, Kujoth GC, Prolla TA, Selak MA, Kundu M, Carroll M, Thompson JE.

Blood. 2009 Nov 5;114(19):4045-53. doi: 10.1182/blood-2008-08-169474. Epub 2009 Sep 4.


H2AX deficiency is associated with erythroid dysplasia and compromised haematopoietic stem cell function.

Zhao B, Tan TL, Mei Y, Yang J, Yu Y, Verma A, Liang Y, Gao J, Ji P.

Sci Rep. 2016 Jan 21;6:19589. doi: 10.1038/srep19589.


Pathogenic mitochondrial DNA-induced respiration defects in hematopoietic cells result in anemia by suppressing erythroid differentiation.

Inoue S, Yokota M, Nakada K, Miyoshi H, Hayashi J.

FEBS Lett. 2007 May 1;581(9):1910-6. Epub 2007 Apr 9.


Dysplasia features of myelodysplastic syndrome in ethnically Chinese people.

Xiong B, Tang ZH, Zou P, Yue QF, Chen WX, Liu XY.

Acta Haematol. 2014;131(2):126-32. doi: 10.1159/000351272. Epub 2013 Oct 22.


Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice.

Li-Harms X, Milasta S, Lynch J, Wright C, Joshi A, Iyengar R, Neale G, Wang X, Wang YD, Prolla TA, Thompson JE, Opferman JT, Green DR, Schuetz J, Kundu M.

Blood. 2015 Jan 1;125(1):162-74. doi: 10.1182/blood-2014-07-586396. Epub 2014 Nov 19.


Physician Education: Myelodysplastic Syndrome.

Yoshida Y.

Oncologist. 1996;1(4):284-287.


Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo.

Braun BS, Archard JA, Van Ziffle JA, Tuveson DA, Jacks TE, Shannon K.

Blood. 2006 Sep 15;108(6):2041-4. Epub 2006 May 23.


Comparison of genetic and clinical aspects in patients with acute myeloid leukemia and myelodysplastic syndromes all with more than 50% of bone marrow erythropoietic cells.

Bacher U, Haferlach C, Alpermann T, Kern W, Schnittger S, Haferlach T.

Haematologica. 2011 Sep;96(9):1284-92. doi: 10.3324/haematol.2011.043687. Epub 2011 May 23.


MtDNA mutagenesis impairs elimination of mitochondria during erythroid maturation leading to enhanced erythrocyte destruction.

Ahlqvist KJ, Leoncini S, Pecorelli A, Wortmann SB, Ahola S, Forsström S, Guerranti R, De Felice C, Smeitink J, Ciccoli L, Hämäläinen RH, Suomalainen A.

Nat Commun. 2015 Mar 9;6:6494. doi: 10.1038/ncomms7494.


Animal model of human disease. Megaloblastic anemia.

Dardick I, Setterfield G, Sheinin R.

Am J Pathol. 1978 Dec;93(3):849-52. No abstract available.


Megaloblastosis: from morphos to molecules.

Das KC, Das M, Mohanty D, Jadaon MM, Gupta A, Marouf R, Easow SK.

Med Princ Pract. 2005;14 Suppl 1:2-14.


Megaloblastic Anemia with Ring Sideroblasts is not Always Myelodysplastic Syndrome.

Narang NC, Kotru M, Rao K, Sikka M.

Turk J Haematol. 2016 Dec 1;33(4):358-359. doi: 10.4274/tjh.2016.0090. Epub 2016 Jul 28. No abstract available.


AML1 mutations induced MDS and MDS/AML in a mouse BMT model.

Watanabe-Okochi N, Kitaura J, Ono R, Harada H, Harada Y, Komeno Y, Nakajima H, Nosaka T, Inaba T, Kitamura T.

Blood. 2008 Apr 15;111(8):4297-308. doi: 10.1182/blood-2007-01-068346. Epub 2008 Jan 11.


Megaloblastic, dyserythropoietic anemia following arsenic ingestion.

Lerman BB, Ali N, Green D.

Ann Clin Lab Sci. 1980 Nov-Dec;10(6):515-7.


Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in Polg mutator mice.

Ahlqvist KJ, Hämäläinen RH, Yatsuga S, Uutela M, Terzioglu M, Götz A, Forsström S, Salven P, Angers-Loustau A, Kopra OH, Tyynismaa H, Larsson NG, Wartiovaara K, Prolla T, Trifunovic A, Suomalainen A.

Cell Metab. 2012 Jan 4;15(1):100-9. doi: 10.1016/j.cmet.2011.11.012.


Special Education: Aplastic Anemia.

Teramura M, Mizoguchi H.

Oncologist. 1996;1(3):187-189.


[Relationship of mitochondrial DNA mutation with myelodysplastic syndromes - review].

Hou L, Liu T.

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2005 Aug;13(4):709-12. Review. Chinese.


Analysis of mitochondrial DNA in 104 patients with myelodysplastic syndromes.

Wulfert M, Küpper AC, Tapprich C, Bottomley SS, Bowen D, Germing U, Haas R, Gattermann N.

Exp Hematol. 2008 May;36(5):577-86. doi: 10.1016/j.exphem.2008.01.004.


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