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Items: 1 to 20 of 97

1.

Multisite comparison of anti-human immunodeficiency virus microbicide activity in explant assays using a novel endpoint analysis.

Richardson-Harman N, Lackman-Smith C, Fletcher PS, Anton PA, Bremer JW, Dezzutti CS, Elliott J, Grivel JC, Guenthner P, Gupta P, Jones M, Lurain NS, Margolis LB, Mohan S, Ratner D, Reichelderfer P, Roberts P, Shattock RJ, Cummins JE Jr.

J Clin Microbiol. 2009 Nov;47(11):3530-9. doi: 10.1128/JCM.00673-09.

2.

In vitro preclinical testing of nonoxynol-9 as potential anti-human immunodeficiency virus microbicide: a retrospective analysis of results from five laboratories.

Beer BE, Doncel GF, Krebs FC, Shattock RJ, Fletcher PS, Buckheit RW Jr, Watson K, Dezzutti CS, Cummins JE, Bromley E, Richardson-Harman N, Pallansch LA, Lackman-Smith C, Osterling C, Mankowski M, Miller SR, Catalone BJ, Welsh PA, Howett MK, Wigdahl B, Turpin JA, Reichelderfer P.

Antimicrob Agents Chemother. 2006 Feb;50(2):713-23.

3.

Prevention of SIV rectal transmission and priming of T cell responses in macaques after local pre-exposure application of tenofovir gel.

Cranage M, Sharpe S, Herrera C, Cope A, Dennis M, Berry N, Ham C, Heeney J, Rezk N, Kashuba A, Anton P, McGowan I, Shattock R.

PLoS Med. 2008 Aug 5;5(8):e157; discussion e157. doi: 10.1371/journal.pmed.0050157.

4.

Dose-response relationship between tissue concentrations of UC781 and explant infectibility with HIV type 1 in the RMP-01 rectal safety study.

Richardson-Harman N, Mauck C, McGowan I, Anton P.

AIDS Res Hum Retroviruses. 2012 Nov;28(11):1422-33. doi: 10.1089/AID.2012.0073.

5.

Colorectal microbicide design: triple combinations of reverse transcriptase inhibitors are optimal against HIV-1 in tissue explants.

Herrera C, Cranage M, McGowan I, Anton P, Shattock RJ.

AIDS. 2011 Oct 23;25(16):1971-9. doi: 10.1097/QAD.0b013e32834b3629.

PMID:
21811139
6.

Inhibition of human immunodeficiency virus type 1 infection by the candidate microbicide dapivirine, a nonnucleoside reverse transcriptase inhibitor.

Fletcher P, Harman S, Azijn H, Armanasco N, Manlow P, Perumal D, de Bethune MP, Nuttall J, Romano J, Shattock R.

Antimicrob Agents Chemother. 2009 Feb;53(2):487-95. doi: 10.1128/AAC.01156-08.

7.

Cyanovirin-N potently inhibits human immunodeficiency virus type 1 infection in cellular and cervical explant models.

Buffa V, Stieh D, Mamhood N, Hu Q, Fletcher P, Shattock RJ.

J Gen Virol. 2009 Jan;90(Pt 1):234-43. doi: 10.1099/vir.0.004358-0.

PMID:
19088294
8.

MIV-150/zinc acetate gel inhibits cell-associated simian-human immunodeficiency virus reverse transcriptase infection in a macaque vaginal explant model.

Barnable P, Calenda G, Bonnaire T, Menon R, Levendosky K, Gettie A, Blanchard J, Cooney ML, Fernández-Romero JA, Zydowsky TM, Teleshova N.

Antimicrob Agents Chemother. 2015 Jul;59(7):3829-37. doi: 10.1128/AAC.00073-15.

9.

Ex vivo culture of human colorectal tissue for the evaluation of candidate microbicides.

Fletcher PS, Elliott J, Grivel JC, Margolis L, Anton P, McGowan I, Shattock RJ.

AIDS. 2006 Jun 12;20(9):1237-45.

PMID:
16816551
10.

Preclinical testing of candidate topical microbicides for anti-human immunodeficiency virus type 1 activity and tissue toxicity in a human cervical explant culture.

Cummins JE Jr, Guarner J, Flowers L, Guenthner PC, Bartlett J, Morken T, Grohskopf LA, Paxton L, Dezzutti CS.

Antimicrob Agents Chemother. 2007 May;51(5):1770-9.

11.

Clinical development of microbicides for the prevention of HIV infection.

D'Cruz OJ, Uckun FM.

Curr Pharm Des. 2004;10(3):315-36. Review.

PMID:
14754390
12.

Candidate polyanion microbicides inhibit HIV-1 infection and dissemination pathways in human cervical explants.

Fletcher PS, Wallace GS, Mesquita PM, Shattock RJ.

Retrovirology. 2006 Aug 1;3:46.

13.

Preclinical evaluation of the HIV-1 fusion inhibitor L'644 as a potential candidate microbicide.

Harman S, Herrera C, Armanasco N, Nuttall J, Shattock RJ.

Antimicrob Agents Chemother. 2012 May;56(5):2347-56. doi: 10.1128/AAC.06108-11.

14.

Use of frozen-thawed cervical tissues in the organ culture system to measure anti-HIV activities of candidate microbicides.

Gupta P, Ratner D, Patterson BK, Kulka K, Rohan LC, Parniak MA, Isaacs CE, Hillier S.

AIDS Res Hum Retroviruses. 2006 May;22(5):419-24.

PMID:
16706618
15.

Study of HIV-1 transmission across cervical mucosa to tonsil tissue cells using an organ culture.

Soto-Rivera J, Patterson BK, Chen Y, Shen C, Ratner D, Ding M, Tumne A, Gupta P.

Am J Reprod Immunol. 2013 Jan;69(1):52-63. doi: 10.1111/aji.12018.

PMID:
23078199
16.

Candidate microbicide PPCM blocks human immunodeficiency virus type 1 infection in cell and tissue cultures and prevents genital herpes in a murine model.

Mesquita PM, Wilson SS, Manlow P, Fischetti L, Keller MJ, Herold BC, Shattock RJ.

J Virol. 2008 Jul;82(13):6576-84. doi: 10.1128/JVI.00335-08.

17.

In vitro and ex vivo testing of tenofovir shows it is effective as an HIV-1 microbicide.

Rohan LC, Moncla BJ, Kunjara Na Ayudhya RP, Cost M, Huang Y, Gai F, Billitto N, Lynam JD, Pryke K, Graebing P, Hopkins N, Rooney JF, Friend D, Dezzutti CS.

PLoS One. 2010 Feb 19;5(2):e9310. doi: 10.1371/journal.pone.0009310.

18.

Phosphorothioate 2' deoxyribose oligomers as microbicides that inhibit human immunodeficiency virus type 1 (HIV-1) infection and block Toll-like receptor 7 (TLR7) and TLR9 triggering by HIV-1.

Fraietta JA, Mueller YM, Do DH, Holmes VM, Howett MK, Lewis MG, Boesteanu AC, Alkan SS, Katsikis PD.

Antimicrob Agents Chemother. 2010 Oct;54(10):4064-73. doi: 10.1128/AAC.00367-10.

19.

A human colorectal explant culture to evaluate topical microbicides for the prevention of HIV infection.

Abner SR, Guenthner PC, Guarner J, Hancock KA, Cummins JE Jr, Fink A, Gilmore GT, Staley C, Ward A, Ali O, Binderow S, Cohen S, Grohskopf LA, Paxton L, Hart CE, Dezzutti CS.

J Infect Dis. 2005 Nov 1;192(9):1545-56.

20.

Inhibition of HIV-1 infection in ex vivo cervical tissue model of human vagina by palmitic acid; implications for a microbicide development.

Lin X, Paskaleva EE, Chang W, Shekhtman A, Canki M.

PLoS One. 2011;6(9):e24803. doi: 10.1371/journal.pone.0024803.

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