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Items: 1 to 20 of 106

1.

The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER.

Stagg HR, Thomas M, van den Boomen D, Wiertz EJ, Drabkin HA, Gemmill RM, Lehner PJ.

J Cell Biol. 2009 Sep 7;186(5):685-92. doi: 10.1083/jcb.200906110. Epub 2009 Aug 31.

2.

Identifying the ERAD ubiquitin E3 ligases for viral and cellular targeting of MHC class I.

van den Boomen DJ, Lehner PJ.

Mol Immunol. 2015 Dec;68(2 Pt A):106-11. doi: 10.1016/j.molimm.2015.07.005. Epub 2015 Jul 22. Review.

3.

TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I.

van den Boomen DJ, Timms RT, Grice GL, Stagg HR, Skødt K, Dougan G, Nathan JA, Lehner PJ.

Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11425-30. doi: 10.1073/pnas.1409099111. Epub 2014 Jul 16.

4.

TRAM1 participates in human cytomegalovirus US2- and US11-mediated dislocation of an endoplasmic reticulum membrane glycoprotein.

Oresic K, Ng CL, Tortorella D.

J Biol Chem. 2009 Feb 27;284(9):5905-14. doi: 10.1074/jbc.M807568200. Epub 2009 Jan 2.

5.
7.

Signal peptide peptidase is required for dislocation from the endoplasmic reticulum.

Loureiro J, Lilley BN, Spooner E, Noriega V, Tortorella D, Ploegh HL.

Nature. 2006 Jun 15;441(7095):894-7. Epub 2006 May 31.

PMID:
16738546
8.

Binding of human cytomegalovirus US2 to major histocompatibility complex class I and II proteins is not sufficient for their degradation.

Chevalier MS, Daniels GM, Johnson DC.

J Virol. 2002 Aug;76(16):8265-75. Erratum in: J Virol 2002 Dec;76(24):13126.

9.

Ubiquitinylation of the cytosolic domain of a type I membrane protein is not required to initiate its dislocation from the endoplasmic reticulum.

Furman MH, Loureiro J, Ploegh HL, Tortorella D.

J Biol Chem. 2003 Sep 12;278(37):34804-11. Epub 2003 Jun 27.

10.

Multiple E2 ubiquitin-conjugating enzymes regulate human cytomegalovirus US2-mediated immunoreceptor downregulation.

van de Weijer ML, Schuren ABC, van den Boomen DJH, Mulder A, Claas FHJ, Lehner PJ, Lebbink RJ, Wiertz EJHJ.

J Cell Sci. 2017 Sep 1;130(17):2883-2892. doi: 10.1242/jcs.206839. Epub 2017 Jul 25.

11.

Forced interaction of cell surface proteins with Derlin-1 in the endoplasmic reticulum is sufficient to induce their dislocation into the cytosol for degradation.

Cho S, Lee M, Jun Y.

Biochem Biophys Res Commun. 2013 Jan 11;430(2):787-92. doi: 10.1016/j.bbrc.2012.11.068. Epub 2012 Dec 1.

PMID:
23206703
12.

Protein disulphide isomerase is required for signal peptide peptidase-mediated protein degradation.

Lee SO, Cho K, Cho S, Kim I, Oh C, Ahn K.

EMBO J. 2010 Jan 20;29(2):363-75. doi: 10.1038/emboj.2009.359. Epub 2009 Nov 26.

13.

MHC class I molecules are preferentially ubiquitinated on endoplasmic reticulum luminal residues during HRD1 ubiquitin E3 ligase-mediated dislocation.

Burr ML, van den Boomen DJ, Bye H, Antrobus R, Wiertz EJ, Lehner PJ.

Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14290-5. doi: 10.1073/pnas.1303380110. Epub 2013 Aug 8.

14.

Ubiquitination of MHC class I heavy chains is essential for dislocation by human cytomegalovirus-encoded US2 but not US11.

Hassink GC, Barel MT, Van Voorden SB, Kikkert M, Wiertz EJ.

J Biol Chem. 2006 Oct 6;281(40):30063-71. Epub 2006 Jul 29.

15.
16.

SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER.

Mueller B, Lilley BN, Ploegh HL.

J Cell Biol. 2006 Oct 23;175(2):261-70. Epub 2006 Oct 16.

18.

A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation.

van de Weijer ML, Bassik MC, Luteijn RD, Voorburg CM, Lohuis MA, Kremmer E, Hoeben RC, LeProust EM, Chen S, Hoelen H, Ressing ME, Patena W, Weissman JS, McManus MT, Wiertz EJ, Lebbink RJ.

Nat Commun. 2014 May 8;5:3832. doi: 10.1038/ncomms4832.

19.

The p97 ATPase dislocates MHC class I heavy chain in US2-expressing cells via a Ufd1-Npl4-independent mechanism.

Soetandyo N, Ye Y.

J Biol Chem. 2010 Oct 15;285(42):32352-9. doi: 10.1074/jbc.M110.131649. Epub 2010 Aug 11.

20.

The HCMV gene products US2 and US11 target MHC class I molecules for degradation in the cytosol.

van der Wal FJ, Kikkert M, Wiertz E.

Curr Top Microbiol Immunol. 2002;269:37-55. Review.

PMID:
12224515

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